STRINGSTRING
LOC735377 LOC735377 ENSPTRP00000064540 ENSPTRP00000064540 TJP2 TJP2 DFFB DFFB LOC107972317 LOC107972317 TICAM2 TICAM2 ENSPTRP00000063547 ENSPTRP00000063547 PSME3-2 PSME3-2 LOC107970066 LOC107970066 ENSPTRP00000063316 ENSPTRP00000063316 PSMD5 PSMD5 ENSPTRP00000062484 ENSPTRP00000062484 ENSPTRP00000062050 ENSPTRP00000062050 H1-0 H1-0 ENSPTRP00000060412 ENSPTRP00000060412 KXD1 KXD1 LOC100614689 LOC100614689 SFN SFN PSMC5 PSMC5 ENSPTRP00000054503 ENSPTRP00000054503 CASP3 CASP3 MAPK3 MAPK3 STK24 STK24 YWHAB YWHAB UBC UBC BAK1 BAK1 DSG3 DSG3 TICAM1 TICAM1 TMEM198 TMEM198 PSMA2 PSMA2 TFDP3 TFDP3 CLSPN CLSPN STK25 STK25 TRADD TRADD PSMB10 PSMB10 CTNNB1 CTNNB1 TNFSF10 TNFSF10 RIPK1 RIPK1 DSP DSP H1-1 H1-1 HIST1H1C HIST1H1C HIST1H1T HIST1H1T HIST1H1E HIST1H1E HIST1H1D HIST1H1D HIST1H1B HIST1H1B PSMB8 PSMB8 PSMB9 PSMB9 BNIP5 BNIP5 PSMB1 PSMB1 SCIN SCIN GSDME GSDME CYCS CYCS NPVF NPVF DBNL DBNL YWHAG YWHAG PSMC2 PSMC2 FNTA FNTA GSDMD GSDMD PLEC PLEC TLR4 TLR4 GSN GSN PSMB7 PSMB7 TRAF2 TRAF2 STK26 STK26 MAP2 MAP2 BMF BMF MAPK8 MAPK8 DAPK1 DAPK1 APAF1 APAF1 DFFA DFFA PSMB2 PSMB2 PSMB4 PSMB4 LMNA LMNA FASLG FASLG PKP1 PKP1 VIM VIM PSMA1 PSMA1 GAS2 GAS2 APIP APIP PSMC3 PSMC3 FADD FADD BIRC2 BIRC2 APPL2 APPL2 DYNLL1 DYNLL1 PSMD9 PSMD9 ACIN1 ACIN1 PSME1 PSME1 PSME2 PSME2 PSMA6 PSMA6 PSMA3 PSMA3 PSMC1 PSMC1 PPP1R13B PPP1R13B TJP1 TJP1 AVEN AVEN BCL2L10 BCL2L10 IGDCC3 IGDCC3 IGDCC4 IGDCC4 UACA UACA PSMA4 PSMA4 SEPTIN1 SEPTIN1 PSMD10 PSMD10 CDH1 CDH1 PSMD7 PSMD7 YWHAE YWHAE C1QBP C1QBP TP53 TP53 PSMD11 PSMD11 PSMD3 PSMD3 NMT1 NMT1 MAPT MAPT KPNB1 KPNB1 DYNLL2 DYNLL2 SEPTIN4 SEPTIN4 PSMA8 PSMA8 DSG1 DSG1 DSG2 DSG2 LMNB2 LMNB2 TJP3 TJP3 DAPK3 DAPK3 PSMD8 PSMD8 YWHAQ YWHAQ RPS27A RPS27A CAPG CAPG PSMD14 PSMD14 CASP8 CASP8 PSMD1 PSMD1 PSMF1 PSMF1 BCL2L1 BCL2L1 E2F1 E2F1 PSMA7 PSMA7 BID BID MAPK1 MAPK1 YWHAH YWHAH PRKCD PRKCD APPL1 APPL1 PSMD6 PSMD6 KPNA1 KPNA1 H1FOO H1FOO PSMD2 PSMD2 TP63 TP63 PAK2 PAK2 ADD1 ADD1 ARHGAP10 ARHGAP10 HMGB2 HMGB2 APC APC LMNB1-2 LMNB1-2 AKT2 AKT2 PSMC6 PSMC6 ENSPTRP00000090249 ENSPTRP00000090249 GSDMB GSDMB BCL2 BCL2 ENSPTRP00000090501 ENSPTRP00000090501 E2F1-2 E2F1-2 UNC5B UNC5B PSMD4 PSMD4 ENSPTRP00000091341 ENSPTRP00000091341 STAT3 STAT3 LMNTD2 LMNTD2 ENSPTRP00000091683 ENSPTRP00000091683 ENSPTRP00000091826 ENSPTRP00000091826 SH3GLB1 SH3GLB1 BCAP31 BCAP31 SCIN-2 SCIN-2 BMX BMX BAX BAX LOC742456 LOC742456 ENSPTRP00000093753 ENSPTRP00000093753 BAD BAD CASP9 CASP9 ENSPTRP00000089486 ENSPTRP00000089486 PSMB5 PSMB5 ENSPTRP00000088766 ENSPTRP00000088766 FAS FAS APC2 APC2 ENSPTRP00000088116 ENSPTRP00000088116 ENSPTRP00000087735 ENSPTRP00000087735 GZMB GZMB PSMC4 PSMC4 LOC101059795 LOC101059795 ENSPTRP00000087091 ENSPTRP00000087091 ENSPTRP00000086535 ENSPTRP00000086535 STK26-2 STK26-2 SH3GLB2-2 SH3GLB2-2 ENSPTRP00000086277 ENSPTRP00000086277 ENSPTRP00000086254 ENSPTRP00000086254 AKT3 AKT3 ENSPTRP00000085846 ENSPTRP00000085846 SP100-2 SP100-2 PSME3 PSME3 LOC459638 LOC459638 ENSPTRP00000085348 ENSPTRP00000085348 DAPK2 DAPK2 ROCK1 ROCK1 ENSPTRP00000084513 ENSPTRP00000084513 LMNB1 LMNB1 PTK2 PTK2 LY96 LY96 AKT1 AKT1 PSME4 PSME4 LOC101058095 LOC101058095 TFDP1 TFDP1 ENSPTRP00000082446 ENSPTRP00000082446 ENSPTRP00000082443 ENSPTRP00000082443 LOC104002760 LOC104002760 ENSPTRP00000082268 ENSPTRP00000082268 ENSPTRP00000082165 ENSPTRP00000082165 ENSPTRP00000081289 ENSPTRP00000081289 CASP6 CASP6 CK820_G0002453 CK820_G0002453 PSMA5 PSMA5 PSMD12 PSMD12 PRKCQ PRKCQ LOC461963 LOC461963 TP53BP2 TP53BP2 CFLAR CFLAR ENSPTRP00000078515 ENSPTRP00000078515 DBNL-2 DBNL-2 ENSPTRP00000077985 ENSPTRP00000077985 MAGED1 MAGED1 LOC100611246 LOC100611246 OPA1 OPA1 ENSPTRP00000077199 ENSPTRP00000077199 ENSPTRP00000076865 ENSPTRP00000076865 ENSPTRP00000076582 ENSPTRP00000076582 ENSPTRP00000076473 ENSPTRP00000076473 OMA1 OMA1 BCL2L11 BCL2L11 HP1BP3 HP1BP3 ENSPTRP00000075697 ENSPTRP00000075697 ENSPTRP00000075494 ENSPTRP00000075494 ENSPTRP00000074972 ENSPTRP00000074972 CASP7 CASP7 SH3GLB2 SH3GLB2 PPP3CC PPP3CC YWHAZ YWHAZ UNC5A UNC5A HMGB1 HMGB1 ENSPTRP00000073673 ENSPTRP00000073673 SATB1 SATB1 LOC471771 LOC471771 XIAP XIAP TNFRSF10B TNFRSF10B ENSPTRP00000072328 ENSPTRP00000072328 TFDP2 TFDP2 PSMD13 PSMD13 LOC470312 LOC470312 DIABLO DIABLO LMNTD1 LMNTD1 MAPK10 MAPK10 DNM1L DNM1L PSMB3 PSMB3 ENSPTRP00000069172 ENSPTRP00000069172 BCAP29 BCAP29 ENSPTRP00000068695 ENSPTRP00000068695 CD14 CD14 TNFRSF10A TNFRSF10A DCC DCC PSMB6 PSMB6 ENSPTRP00000068204 ENSPTRP00000068204 CARD8 CARD8 ENSPTRP00000067920 ENSPTRP00000067920 SEPTIN5 SEPTIN5 ENSPTRP00000067251 ENSPTRP00000067251 LOC100615261 LOC100615261 ENSPTRP00000065877 ENSPTRP00000065877 HMGB3 HMGB3 ENSPTRP00000065241 ENSPTRP00000065241 LOC469195 LOC469195 SPTAN1 SPTAN1 TP73 TP73
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC735377Dynein light chain 1, cytoplasmic-like. (89 aa)
ENSPTRP00000064540annotation not available (358 aa)
TJP2Tight junction protein 2; Belongs to the MAGUK family. (1249 aa)
DFFBDNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase). (338 aa)
LOC107972317Cytochrome c-like. (102 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
ENSPTRP00000063547Cytochrome c. (105 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
LOC107970066LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1. (198 aa)
ENSPTRP00000063316annotation not available (235 aa)
PSMD5PSMD5 isoform 1. (509 aa)
ENSPTRP00000062484annotation not available (224 aa)
ENSPTRP00000062050annotation not available (183 aa)
H1-0H1F0 isoform 1. (194 aa)
ENSPTRP00000060412annotation not available (156 aa)
KXD1UBA52 isoform 10. (231 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
ENSPTRP00000054503annotation not available (205 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
STK24Serine/threonine kinase 24. (443 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
DSG3DSG3 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (982 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (543 aa)
TMEM198Transmembrane protein 198. (360 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TFDP3Transcription factor. (405 aa)
CLSPNCLSPN isoform 1. (1365 aa)
STK25Serine/threonine kinase 25. (426 aa)
TRADDTNFRSF1A-associated via death domain. (312 aa)
PSMB10Proteasome subunit beta type-10. (273 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (282 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
DSPDSP isoform 1. (2871 aa)
H1-1HIST1H1A isoform 1. (215 aa)
HIST1H1CHIST1H1C isoform 1. (213 aa)
HIST1H1THIST1H1T isoform 1. (209 aa)
HIST1H1EHistone cluster 1 H1 family member e. (219 aa)
HIST1H1DHIST1H1D isoform 1. (221 aa)
HIST1H1BHIST1H1B isoform 1. (226 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (218 aa)
BNIP5BCL2 interacting protein 5. (652 aa)
PSMB1Proteasome subunit beta. (241 aa)
SCINSCIN isoform 3. (715 aa)
GSDMEDeafness, autosomal dominant 5. (496 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
NPVFNeuropeptide VF precursor. (196 aa)
DBNLDBNL isoform 5. (439 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family. (247 aa)
PSMC2Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa)
FNTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. (386 aa)
GSDMDGSDMD isoform 4. (533 aa)
PLECPLEC isoform 2. (4684 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
GSNGSN isoform 3. (782 aa)
PSMB7Proteasome subunit beta. (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
STK26Serine/threonine kinase 26. (438 aa)
MAP2Microtubule-associated protein. (1827 aa)
BMFBcl2 modifying factor. (184 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DAPK1Death-associated protein kinase 1. (1440 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
PKP1PKP1 isoform 2. (747 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
GAS2GAS2 isoform 1. (314 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa)
PSMC3Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
DYNLL1Dynein light chain. (89 aa)
PSMD9Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 9. (223 aa)
ACIN1ACIN1 isoform 7. (1342 aa)
PSME1Proteasome (Prosome, macropain) activator subunit 1 (PA28 alpha). (250 aa)
PSME2Proteasome (Prosome, macropain) activator subunit 2 (PA28 beta). (239 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC1Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
PPP1R13BProtein phosphatase 1, regulatory (Inhibitor) subunit 13B. (1090 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1748 aa)
AVENApoptosis and caspase activation inhibitor. (358 aa)
BCL2L10BCL2L10 isoform 1. (204 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (814 aa)
IGDCC4IGDCC4 isoform 1. (1250 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1416 aa)
PSMA4Proteasome subunit alpha type-4 isoform X2. (261 aa)
SEPTIN1SEPT1 isoform 3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (414 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
PSMD7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
C1QBPComplement component 1, q subcomponent binding protein. (282 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PSMD11Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
PSMD3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
MAPTMicrotubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] (776 aa)
KPNB1Karyopherin (Importin) beta 1. (876 aa)
DYNLL2Dynein light chain. (89 aa)
SEPTIN4C17orf47 isoform 1. (1012 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
DSG1DSG1 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1048 aa)
DSG2DSG2 isoform 1. (1118 aa)
LMNB2LMNB2 isoform 1; Belongs to the intermediate filament family. (620 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (928 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
PSMD8Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 8. (350 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (253 aa)
RPS27ARPS27A isoform 1. (156 aa)
CAPGCapping actin protein, gelsolin like. (348 aa)
PSMD14Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMF1Proteasome (Prosome, macropain) inhibitor subunit 1 (PI31). (271 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
E2F1E2F transcription factor 1. (437 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
APPL1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa)
PSMD6Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
H1FOOH1FOO isoform 2. (346 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
ADD1ADD1 isoform 5. (768 aa)
ARHGAP10Rho GTPase activating protein 10. (786 aa)
HMGB2High-mobility group box 2. (209 aa)
APCAdenomatous polyposis coli protein isoform X10. (2844 aa)
LMNB1-2LMNB1 isoform 1; Belongs to the intermediate filament family. (586 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMC6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa)
ENSPTRP00000090249annotation not available (96 aa)
GSDMBGSDMB isoform 2. (416 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000090501annotation not available (192 aa)
E2F1-2E2F transcription factor 1. (437 aa)
UNC5BUNC5B isoform 2. (945 aa)
PSMD4PSMD4 isoform 2. (382 aa)
ENSPTRP00000091341annotation not available (379 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
LMNTD2LMNTD2 isoform 1. (705 aa)
ENSPTRP00000091683annotation not available (342 aa)
ENSPTRP00000091826annotation not available (117 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
BCAP31BCAP31 isoform 3. (246 aa)
SCIN-2SCIN isoform 2. (715 aa)
BMXTyrosine-protein kinase. (679 aa)
BAXBAX isoform 7. (123 aa)
LOC742456Cytochrome c-like. (105 aa)
ENSPTRP00000093753Dynein light chain 1, cytoplasmic-like. (87 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
ENSPTRP00000089486annotation not available (110 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSPTRP00000088766annotation not available (199 aa)
FASFas (TNF receptor superfamily, member 6). (337 aa)
APC2APC2 isoform 1. (2301 aa)
ENSPTRP00000088116annotation not available (384 aa)
ENSPTRP00000087735annotation not available (204 aa)
GZMBGZMB isoform 2; Belongs to the peptidase S1 family. (280 aa)
PSMC4Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa)
LOC10105979526S proteasome non-ATPase regulatory subunit 2 pseudogene. (829 aa)
ENSPTRP00000087091annotation not available (177 aa)
ENSPTRP00000086535annotation not available (351 aa)
STK26-2Serine/threonine protein kinase MST4. (416 aa)
SH3GLB2-2SH3 domain containing GRB2 like, endophilin B2. (404 aa)
ENSPTRP00000086277annotation not available (106 aa)
ENSPTRP00000086254Microtubule-associated protein tau. (776 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPTRP00000085846annotation not available (426 aa)
SP100-2Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (187 aa)
PSME3Proteasome activator subunit 3. (265 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000085348annotation not available (302 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ENSPTRP00000084513annotation not available (205 aa)
LMNB1Lamin B1. (586 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
LY96Lymphocyte antigen 96. (160 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
PSME4Proteasome (Prosome, macropain) activator subunit 4. (1844 aa)
LOC10105809514-3-3 protein zeta/delta pseudogene. (238 aa)
TFDP1Transcription factor. (352 aa)
ENSPTRP00000082446annotation not available (194 aa)
ENSPTRP00000082443annotation not available (351 aa)
LOC104002760Cytochrome c. (110 aa)
ENSPTRP00000082268annotation not available (246 aa)
ENSPTRP00000082165annotation not available (192 aa)
ENSPTRP00000081289annotation not available (192 aa)
CASP6Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
CK820_G0002453PSMC6 isoform 12. (340 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa)
LOC461963PSME2 isoform 10. (224 aa)
TP53BP2Tumor protein p53 binding protein 2. (1137 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ENSPTRP00000078515annotation not available (198 aa)
DBNL-2Drebrin like. (439 aa)
ENSPTRP00000077985annotation not available (153 aa)
MAGED1MAGE family member D1. (834 aa)
LOC10061124614-3-3 protein zeta/delta pseudogene. (212 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
ENSPTRP00000077199annotation not available (206 aa)
ENSPTRP00000076865annotation not available (107 aa)
ENSPTRP00000076582annotation not available (377 aa)
ENSPTRP00000076473annotation not available (202 aa)
OMA1OMA1 isoform 2. (420 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
HP1BP3Heterochromatin protein 1, binding protein 3. (553 aa)
ENSPTRP00000075697annotation not available (207 aa)
ENSPTRP00000075494annotation not available (194 aa)
ENSPTRP00000074972annotation not available (252 aa)
CASP7CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
SH3GLB2SH3GLB2 isoform 7. (389 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
HMGB1HMGB1 isoform 1. (215 aa)
ENSPTRP00000073673annotation not available (196 aa)
SATB1DNA-binding protein SATB. (795 aa)
LOC471771High mobility group protein B3-like isoform X1. (178 aa)
XIAPBaculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (497 aa)
TNFRSF10BTNF receptor superfamily member 10b. (439 aa)
ENSPTRP00000072328annotation not available (210 aa)
TFDP2Transcription factor. (447 aa)
PSMD13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
LOC47031226S proteasome regulatory subunit 4 pseudogene. (374 aa)
DIABLODiablo, IAP-binding mitochondrial protein. (239 aa)
LMNTD1LMNTD1 isoform 6. (409 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
DNM1LDNM1L isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSPTRP00000069172annotation not available (353 aa)
BCAP29BCAP29 isoform 2. (330 aa)
ENSPTRP00000068695annotation not available (105 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (384 aa)
TNFRSF10ATumor necrosis factor receptor superfamily, member 10a. (469 aa)
DCCDCC isoform 1. (1457 aa)
PSMB6Proteasome subunit beta. (244 aa)
ENSPTRP0000006820414-3-3 protein homolog 1-like. (78 aa)
CARD8Caspase recruitment domain family member 8. (537 aa)
ENSPTRP00000067920annotation not available (392 aa)
SEPTIN5SEPT5 isoform 5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (378 aa)
ENSPTRP00000067251annotation not available (74 aa)
LOC10061526114-3-3 protein theta-like. (74 aa)
ENSPTRP00000065877annotation not available (115 aa)
HMGB3High mobility group box 3. (207 aa)
ENSPTRP00000065241annotation not available (350 aa)
LOC469195Dynein light chain 1, cytoplasmic-like. (89 aa)
SPTAN1SPTAN1 isoform 9. (2498 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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