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THAP6 THAP6 PDE4A PDE4A CAMK2G CAMK2G GNAI3 GNAI3 PLA2G4A PLA2G4A GNG4 GNG4 GNG3 GNG3 GRK2 GRK2 PPP2R1B PPP2R1B PDE1B PDE1B PPP1CA PPP1CA CAMKK2 CAMKK2 ADCY4 ADCY4 PLCB2 PLCB2 GNB5 GNB5 ADCY9 ADCY9 PPP1R1B PPP1R1B PRKCA PRKCA PRKACA PRKACA CALM3 CALM3 PRKCG PRKCG PTRHD1 PTRHD1 ADCY3 ADCY3 PDYN PDYN PLCB1 PLCB1 PLCB4 PLCB4 CNBD2 CNBD2 THAP7 THAP7 MAPK1 MAPK1 ITPR2 ITPR2 ITPR1 ITPR1 GNAI2 GNAI2 PRKCD PRKCD ADCY5 ADCY5 GNB4 GNB4 CAMK4 CAMK4 ENSPTRP00000029492 ENSPTRP00000029492 ITPR3 ITPR3 PPP2R5D PPP2R5D ADCY1 ADCY1 GNGT1 GNGT1 GNG11 GNG11 PRKACG PRKACG GNG10 GNG10 PRKACB PRKACB OPRM1 OPRM1 GNB3 GNB3 PRKAR1A PRKAR1A LRBA LRBA GNAQ GNAQ POMC POMC GNAT3 GNAT3 ENSPTRP00000056983 ENSPTRP00000056983 PRKAR2B PRKAR2B GNGT2 GNGT2 PRKY PRKY GNG12 GNG12 ADCY7 ADCY7 GNG13 GNG13 PPP2CA PPP2CA PPP3CB PPP3CB ADCY1-2 ADCY1-2 GNG2 GNG2 ENSPTRP00000065686 ENSPTRP00000065686 PDE4B PDE4B AHCYL1 AHCYL1 GNB1 GNB1 PDE4D PDE4D PPP3CA PPP3CA ENSPTRP00000067784 ENSPTRP00000067784 PDE4C PDE4C GNG7 GNG7 PRKAR1B PRKAR1B KPNA2 KPNA2 ENSPTRP00000070111 ENSPTRP00000070111 PRKX PRKX ENSPTRP00000071036 ENSPTRP00000071036 ENSPTRP00000071372 ENSPTRP00000071372 GNAI1 GNAI1 NBEA NBEA CREB1 CREB1 CAMK2B CAMK2B GNA11 GNA11 PPP3CC PPP3CC CK820_G0016908 CK820_G0016908 ENSPTRP00000075783 ENSPTRP00000075783 GNAL GNAL ENSPTRP00000077377 ENSPTRP00000077377 ADCY8 ADCY8 CAMK2A CAMK2A CDK5 CDK5 PDE1A PDE1A PDE1C PDE1C DCLK1 DCLK1 PPP2R1A PPP2R1A ADCY2 ADCY2 ENSPTRP00000083779 ENSPTRP00000083779 ENSPTRP00000084437 ENSPTRP00000084437 GNB2 GNB2 PLCB3 PLCB3 PPP2CB PPP2CB ENSPTRP00000088150 ENSPTRP00000088150 CAMK2D CAMK2D ENSPTRP00000089644 ENSPTRP00000089644 ENSPTRP00000090121 ENSPTRP00000090121 GNG8 GNG8 PRKAR2A PRKAR2A GNA14 GNA14 CAMKK1 CAMKK1 GNB2-2 GNB2-2 CK820_G0040666 CK820_G0040666 GNA15 GNA15 ADCY6 ADCY6 ENSPTRP00000093443 ENSPTRP00000093443
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THAP6THAP domain containing 6. (222 aa)
PDE4APhosphodiesterase. (886 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase II gamma. (562 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
PDE1BPhosphodiesterase. (536 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
GNB5GNB5 isoform 1. (409 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PDYNPDYN isoform 1. (254 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CNBD2CNBD2 isoform 3. (511 aa)
THAP7THAP domain containing 7. (309 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ENSPTRP00000029492annotation not available (223 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
GNB3G protein subunit beta 3. (340 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
LRBALRBA isoform 8. (747 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
POMCProopiomelanocortin. (268 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
ENSPTRP00000056983annotation not available (477 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PRKYSerine/threonine-protein kinase PRKX. (358 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
ENSPTRP00000065686annotation not available (506 aa)
PDE4BPhosphodiesterase. (736 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
PDE4DPhosphodiesterase. (809 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSPTRP00000067784annotation not available (357 aa)
PDE4CPhosphodiesterase. (713 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
ENSPTRP00000070111annotation not available (324 aa)
PRKXProtein kinase, X-linked; Belongs to the protein kinase superfamily. (358 aa)
ENSPTRP00000071036annotation not available (68 aa)
ENSPTRP00000071372annotation not available (243 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
NBEANBEA isoform 7. (2947 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
CK820_G0016908LRBA isoform 14. (265 aa)
ENSPTRP00000075783annotation not available (149 aa)
GNALG protein subunit alpha L. (458 aa)
ENSPTRP00000077377annotation not available (149 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
PDE1APhosphodiesterase. (572 aa)
PDE1CPhosphodiesterase. (769 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ENSPTRP00000083779annotation not available (309 aa)
ENSPTRP00000084437annotation not available (441 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ENSPTRP00000088150annotation not available (75 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
ENSPTRP00000089644annotation not available (335 aa)
ENSPTRP00000090121annotation not available (331 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
GNA14Guanine nucleotide binding protein (G protein), alpha 14. (355 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
GNB2-2G protein subunit beta 2. (372 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
GNA15G protein subunit alpha 15. (374 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ENSPTRP00000093443annotation not available (57 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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