28 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	TMEM198	Transmembrane protein 198. (360 aa)
	HIST1H1B	HIST1H1B isoform 1. (226 aa)
	HIST1H1D	HIST1H1D isoform 1. (221 aa)
	HIST1H1E	Histone cluster 1 H1 family member e. (219 aa)
	HIST1H1T	HIST1H1T isoform 1. (209 aa)
	HIST1H1C	HIST1H1C isoform 1. (213 aa)
	H1-1	HIST1H1A isoform 1. (215 aa)
	HMGB2	High-mobility group box 2. (209 aa)
	KPNA1	Importin subunit alpha; Functions in nuclear protein import. (538 aa)
	KPNB1	Karyopherin (Importin) beta 1. (876 aa)
	DFFA	DNA fragmentation factor subunit alpha. (331 aa)
	ENSPTRP00000076473	annotation not available (202 aa)
	ENSPTRP00000081289	annotation not available (192 aa)
	ENSPTRP00000082165	annotation not available (192 aa)
	SP100-2	Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (187 aa)
	ENSPTRP00000086277	annotation not available (106 aa)
	ENSPTRP00000087091	annotation not available (177 aa)
	ENSPTRP00000087735	annotation not available (204 aa)
	ENSPTRP00000075697	annotation not available (207 aa)
	HMGB1	HMGB1 isoform 1. (215 aa)
	LOC471771	High mobility group protein B3-like isoform X1. (178 aa)
	ENSPTRP00000072328	annotation not available (210 aa)
	HMGB3	High mobility group box 3. (207 aa)
	DFFB	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase). (338 aa)
	LOC107970066	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1. (198 aa)
	ENSPTRP00000062050	annotation not available (183 aa)
	H1-0	H1F0 isoform 1. (194 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	DFFA	ENSPTRP00000054330	ENSPTRP00000000259	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	DNA fragmentation factor subunit alpha.	0.991
CASP3	DFFB	ENSPTRP00000054330	ENSPTRP00000064348	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	0.879
CASP3	ENSPTRP00000072328	ENSPTRP00000054330	ENSPTRP00000072328	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	annotation not available	0.425
CASP3	ENSPTRP00000075697	ENSPTRP00000054330	ENSPTRP00000075697	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	annotation not available	0.414
CASP3	ENSPTRP00000087735	ENSPTRP00000054330	ENSPTRP00000087735	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	annotation not available	0.425
CASP3	HMGB1	ENSPTRP00000054330	ENSPTRP00000074016	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	HMGB1 isoform 1.	0.425
CASP3	KPNA1	ENSPTRP00000054330	ENSPTRP00000026363	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Importin subunit alpha; Functions in nuclear protein import.	0.498
CASP3	KPNB1	ENSPTRP00000054330	ENSPTRP00000015867	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Karyopherin (Importin) beta 1.	0.459
CASP3	LOC107970066	ENSPTRP00000054330	ENSPTRP00000063377	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1.	0.425
CASP3	SP100-2	ENSPTRP00000054330	ENSPTRP00000085783	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...]	0.425
DFFA	CASP3	ENSPTRP00000000259	ENSPTRP00000054330	DNA fragmentation factor subunit alpha.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.991
DFFA	DFFB	ENSPTRP00000000259	ENSPTRP00000064348	DNA fragmentation factor subunit alpha.	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	0.999
DFFB	CASP3	ENSPTRP00000064348	ENSPTRP00000054330	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.879
DFFB	DFFA	ENSPTRP00000064348	ENSPTRP00000000259	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	DNA fragmentation factor subunit alpha.	0.999
DFFB	H1-0	ENSPTRP00000064348	ENSPTRP00000061378	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	H1F0 isoform 1.	0.836
DFFB	H1-1	ENSPTRP00000064348	ENSPTRP00000030384	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	HIST1H1A isoform 1.	0.570
DFFB	HIST1H1B	ENSPTRP00000064348	ENSPTRP00000030452	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	HIST1H1B isoform 1.	0.565
DFFB	HIST1H1C	ENSPTRP00000064348	ENSPTRP00000030392	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	HIST1H1C isoform 1.	0.533
DFFB	HIST1H1D	ENSPTRP00000064348	ENSPTRP00000030407	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	HIST1H1D isoform 1.	0.565
DFFB	HIST1H1T	ENSPTRP00000064348	ENSPTRP00000030394	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	HIST1H1T isoform 1.	0.401