STRINGSTRING
ADCY1 ADCY1 PRKAA2 PRKAA2 CACNA1E CACNA1E ADIPOR1 ADIPOR1 GNG4 GNG4 CHRM3 CHRM3 TALDO1 TALDO1 GNG3 GNG3 PPP2R1B PPP2R1B CACNA1C CACNA1C RAPGEF3 RAPGEF3 MLXIP MLXIP ADCY4 ADCY4 PLCB2 PLCB2 GNB5 GNB5 IQGAP1 IQGAP1 ADCY9 ADCY9 MLX MLX PRKCA PRKCA FASN FASN KCNG2 KCNG2 STK11 STK11 PRKACA PRKACA FFAR1 FFAR1 SYT5 SYT5 KCNS3 KCNS3 ADCY3 ADCY3 FAP FAP ACSL3 ACSL3 PLCB1 PLCB1 SNAP25 SNAP25 CNBD2 CNBD2 KCNB1 KCNB1 THAP7 THAP7 ITPR2 ITPR2 ITPR1 ITPR1 GNAI2 GNAI2 ADCY5 ADCY5 SLC2A2 SLC2A2 GNB4 GNB4 ADIPOQ ADIPOQ TKTL2 TKTL2 ENSPTRP00000029492 ENSPTRP00000029492 ITPR3 ITPR3 GLP1R GLP1R PPP2R5D PPP2R5D CK820_G0040666 CK820_G0040666 GNA15 GNA15 ADCY6 ADCY6 THAP6 THAP6 ENSPTRP00000093443 ENSPTRP00000093443 GNB2-2 GNB2-2 GNA14 GNA14 PRKAR2A PRKAR2A GNG8 GNG8 PRKAG2 PRKAG2 CACNA2D2 CACNA2D2 PPP2CB PPP2CB STX1A-2 STX1A-2 CACNB3 CACNB3 STXBP1 STXBP1 PLCB3 PLCB3 GNB2 GNB2 RAP1A RAP1A TKTL1 TKTL1 ENSPTRP00000083779 ENSPTRP00000083779 ADCY2 ADCY2 PPP2R1A PPP2R1A CACNA1A CACNA1A CK820_G0015962 CK820_G0015962 TKT TKT PFKFB1 PFKFB1 ACACB ACACB PRKAB2 PRKAB2 KCNC2 KCNC2 PRKAG2-2 PRKAG2-2 SLC2A1 SLC2A1 INS INS ADCY8 ADCY8 ENSPTRP00000077377 ENSPTRP00000077377 CACNA1D CACNA1D ENSPTRP00000076429 ENSPTRP00000076429 ENSPTRP00000075783 ENSPTRP00000075783 CD36 CD36 GNA11 GNA11 ACACA ACACA GNAI1 GNAI1 CACNA2D1 CACNA2D1 AGPAT1 AGPAT1 ENSPTRP00000071036 ENSPTRP00000071036 ENSPTRP00000070111 ENSPTRP00000070111 PRKAR1B PRKAR1B GNG7 GNG7 RAPGEFL1 RAPGEFL1 GNB1 GNB1 AHCYL1 AHCYL1 MLXIPL-2 MLXIPL-2 GNG2 GNG2 ADCY1-2 ADCY1-2 PPP2CA PPP2CA GNG13 GNG13 ADCY7 ADCY7 GNG12 GNG12 RAPGEF4 RAPGEF4 ADRA2A ADRA2A GNGT2 GNGT2 PRKAR2B PRKAR2B ADRA2C ADRA2C GNAS GNAS VAMP2 VAMP2 GCGR GCGR RAPGEF5 RAPGEF5 PKLR PKLR AKAP5 AKAP5 GNAQ GNAQ GCG GCG KCNJ11 KCNJ11 ABCC8 ABCC8 PRKAR1A PRKAR1A GNB3 GNB3 CACNB2 CACNB2 ADIPOR2 ADIPOR2 ACLY ACLY PRKACB PRKACB ACSL4 ACSL4 CACNA1F CACNA1F GNG10 GNG10 PRKACG PRKACG GNG11 GNG11 GNGT1 GNGT1 STX1A STX1A MLXIPL MLXIPL MARCKS MARCKS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CHRM3Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). (590 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
MLXIPMLX interacting protein. (919 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
GNB5GNB5 isoform 1. (409 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MLXMAX dimerization protein MLX. (298 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
FASNFatty acid synthase. (2511 aa)
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (467 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
SYT5Synaptotagmin 5. (386 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
FAPFibroblast activation protein, alpha; Belongs to the peptidase S9B family. (760 aa)
ACSL3Acyl-CoA synthetase long-chain family member 3. (720 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; Belongs to the SNAP-25 family. (206 aa)
CNBD2CNBD2 isoform 3. (511 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
THAP7THAP domain containing 7. (309 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
TKTL2TKTL2 isoform 1. (722 aa)
ENSPTRP00000029492annotation not available (223 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
GNA15G protein subunit alpha 15. (374 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
THAP6THAP domain containing 6. (222 aa)
ENSPTRP00000093443annotation not available (57 aa)
GNB2-2G protein subunit beta 2. (372 aa)
GNA14Guanine nucleotide binding protein (G protein), alpha 14. (355 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PRKAG2PRKAG2 isoform 4. (445 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
STX1A-2Syntaxin 1A. (344 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TKTL1TKTL1 isoform 3. (598 aa)
ENSPTRP00000083779annotation not available (309 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
CK820_G0015962ACACB isoform 16. (191 aa)
TKTTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (631 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
ACACBACACB isoform 2. (2458 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
SLC2A1Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ENSPTRP00000077377annotation not available (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSPTRP00000076429annotation not available (110 aa)
ENSPTRP00000075783annotation not available (149 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (288 aa)
ENSPTRP00000071036annotation not available (68 aa)
ENSPTRP00000070111annotation not available (324 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (662 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
MLXIPL-2MLX interacting protein like. (852 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
RAPGEF4RAPGEF4 isoform 2. (1011 aa)
ADRA2AAdrenergic, alpha-2A-, receptor. (465 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GNASGNAS isoform 19. (1042 aa)
VAMP2VAMP2 isoform 3. (118 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (480 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
GCGGCG isoform 1. (180 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ABCC8ABCC8 isoform 2. (1582 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1134 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
STX1ASTX1A isoform 3; Belongs to the syntaxin family. (288 aa)
MLXIPLMLX interacting protein like. (852 aa)
MARCKSMyristoylated alanine-rich protein kinase C substrate. (332 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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