STRINGSTRING
FNDC3A FNDC3A PIK3CA PIK3CA FNDC3B FNDC3B LPXN LPXN ENSPTRP00000092364 ENSPTRP00000092364 CBL CBL HRAS HRAS STAM STAM NRAS NRAS EPS15 EPS15 GRB2 GRB2 HGS HGS PTPRM PTPRM SH3GL1 SH3GL1 EPS15L1 EPS15L1 EPN1 EPN1 RPS27A RPS27A AAMP AAMP PLCG1 PLCG1 EPGN EPGN EREG EREG BTC BTC EGF EGF GAB1 GAB1 HBEGF HBEGF PTPN12 PTPN12 PAG1 PAG1 PTPRT PTPRT ADAM12 ADAM12 UBC UBC SHC1 SHC1 LOC104004057 LOC104004057 SOS1 SOS1 ADAM17 ADAM17 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 PTPN11 PTPN11 AREG AREG ARHGEF7 ARHGEF7 ERAS ERAS ENSPTRP00000066583 ENSPTRP00000066583 ENSPTRP00000067174 ENSPTRP00000067174 ENSPTRP00000067263 ENSPTRP00000067263 LOC468305 LOC468305 PTPN3 PTPN3 EGFR EGFR PXN PXN CSDE1 CSDE1 ENSPTRP00000071568 ENSPTRP00000071568 LRIG1 LRIG1 PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 PXN-2 PXN-2 STAM2 STAM2 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 CDC42 CDC42 TGFA TGFA PTPRK PTPRK TGFB1I1 TGFB1I1 ENSPTRP00000081694 ENSPTRP00000081694 SH3GL2 SH3GL2 SH3KBP1 SH3KBP1 SPRY1 SPRY1 KRAS KRAS RNF222 RNF222 SH3GL3 SH3GL3 CSK CSK ADAM10 ADAM10 SPRY2 SPRY2 LRIG3 LRIG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (391 aa)
ENSPTRP00000092364annotation not available (574 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
STAMSignal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (540 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (896 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
PTPRMPTPRM isoform 4. (1465 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa)
EPN1EPN1 isoform 5. (662 aa)
RPS27ARPS27A isoform 1. (156 aa)
AAMPAngio associated migratory cell protein. (435 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
EPGNEpithelial mitogen. (154 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1451 aa)
ADAM12ADAM metallopeptidase domain 12. (909 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
LOC104004057Uncharacterized protein. (987 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ADAM17ADAM17 isoform 3. (999 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
AREGAREG isoform 2. (274 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
ERASES cell expressed Ras. (233 aa)
ENSPTRP00000066583annotation not available (181 aa)
ENSPTRP00000067174annotation not available (502 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
LOC468305endophilin-A2 pseudogene. (385 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PXNPXN isoform 20. (1078 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSPTRP00000071568annotation not available (98 aa)
LRIG1LRIG1 isoform 3. (1091 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
PXN-2PXN isoform 9. (1081 aa)
STAM2Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (525 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
TGFATGFA isoform 6. (193 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
ENSPTRP00000081694annotation not available (182 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
SH3KBP1SH3KBP1 isoform 2. (665 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
RNF222Ring finger protein 222. (220 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
CSKTyrosine-protein kinase. (450 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
SPRY2Sprouty homolog 2. (338 aa)
LRIG3LRIG3 isoform 1. (1119 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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