STRINGSTRING
CSK CSK RNF222 RNF222 GRB2 GRB2 EPGN EPGN EREG EREG BTC BTC EGF EGF GAB1 GAB1 HBEGF HBEGF PAG1 PAG1 PTPN11 PTPN11 AREG AREG ENSPTRP00000067174 ENSPTRP00000067174 EGFR EGFR PXN PXN PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 PXN-2 PXN-2 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 TGFA TGFA TGFB1I1 TGFB1I1 FNDC3A FNDC3A PIK3CA PIK3CA FNDC3B FNDC3B LPXN LPXN ENSPTRP00000092364 ENSPTRP00000092364
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSKTyrosine-protein kinase. (450 aa)
RNF222Ring finger protein 222. (220 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
EPGNEpithelial mitogen. (154 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
AREGAREG isoform 2. (274 aa)
ENSPTRP00000067174annotation not available (502 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PXNPXN isoform 20. (1078 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
PXN-2PXN isoform 9. (1081 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
TGFATGFA isoform 6. (193 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (391 aa)
ENSPTRP00000092364annotation not available (574 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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