55 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNW1	SNW domain containing 1. (571 aa)
	MAMLD1	MAMLD1 isoform 3. (984 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	ONECUT3	One cut domain family member. (472 aa)
	HNF4G	HNF4G isoform 4. (461 aa)
	ONECUT1	One cut domain family member. (465 aa)
	CREBBP	CREB binding protein. (2442 aa)
	RFX4	Regulatory factor X4. (744 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
	FOXA2	FOXA2 isoform 1. (464 aa)
	NEUROD2	Neurogenic differentiation factor. (382 aa)
	ENSPTRP00000089297	annotation not available (265 aa)
	ENSPTRP00000087746	annotation not available (429 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	NEUROG2	NEUROG2 isoform 1. (272 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PTF1A	Pancreas associated transcription factor 1a. (328 aa)
	AKT1	AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
	HNF1B	HNF1 homeobox B. (557 aa)
	ENSPTRP00000082196	annotation not available (376 aa)
	ENSPTRP00000081714	annotation not available (310 aa)
	MAMLD1-2	Mastermind-like domain containing 1. (722 aa)
	ONECUT2	One cut domain family member. (504 aa)
	MAML3	MAML3 isoform 1. (1134 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	KAT2A	Histone acetyltransferase KAT2A isoform X1. (837 aa)
	INSM2	INSM transcriptional repressor 2. (568 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	NKX6-2	NKX6-2 isoform 1. (276 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1150 aa)
	IAPP	Islet amyloid polypeptide. (89 aa)
	PDX1	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
	FOXO1	FOXO1 isoform 1. (655 aa)
	NEUROD4	Neurogenic differentiation factor. (331 aa)
	ENSPTRP00000060300	annotation not available (221 aa)
	NEUROG3	NEUROG3 isoform 1. (214 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	HES4	Hes family bHLH transcription factor 4. (221 aa)
	GCK	Phosphotransferase. (466 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	MAFA	MAF bZIP transcription factor A. (348 aa)
	PAX4	PAX4 isoform 1. (351 aa)
	RFX6	RFX6 isoform 1. (928 aa)
	NEUROG1	NEUROG1 isoform 1. (237 aa)
	NKX6-1	NKX6-1 isoform 2. (367 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
	EP300	E1A binding protein p300. (2175 aa)
	NKX2-2	NKX2-2 isoform 1. (273 aa)
	FOXA3	FOXA3 isoform 2. (350 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSPTRP00000082849	ENSPTRP00000089692	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.988
AKT1	AKT3	ENSPTRP00000082849	ENSPTRP00000086046	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.951
AKT1	CREBBP	ENSPTRP00000082849	ENSPTRP00000074980	AKT1 isoform 3; Belongs to the protein kinase superfamily.	CREB binding protein.	0.655
AKT1	ENSPTRP00000089297	ENSPTRP00000082849	ENSPTRP00000089297	AKT1 isoform 3; Belongs to the protein kinase superfamily.	annotation not available	0.931
AKT1	EP300	ENSPTRP00000082849	ENSPTRP00000024841	AKT1 isoform 3; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.904
AKT1	FGF10	ENSPTRP00000082849	ENSPTRP00000083399	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.516
AKT1	FOXO1	ENSPTRP00000082849	ENSPTRP00000009886	AKT1 isoform 3; Belongs to the protein kinase superfamily.	FOXO1 isoform 1.	0.992
AKT1	HNF4A	ENSPTRP00000082849	ENSPTRP00000087554	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Hepatocyte nuclear factor 4 alpha.	0.503
AKT1	INS	ENSPTRP00000082849	ENSPTRP00000077843	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.747
AKT1	NOTCH1	ENSPTRP00000082849	ENSPTRP00000036924	AKT1 isoform 3; Belongs to the protein kinase superfamily.	NOTCH1 isoform 1.	0.704
AKT1	SLC2A2	ENSPTRP00000082849	ENSPTRP00000026876	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.479
AKT2	AKT1	ENSPTRP00000089692	ENSPTRP00000082849	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.988
AKT2	AKT3	ENSPTRP00000089692	ENSPTRP00000086046	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.957
AKT2	ENSPTRP00000089297	ENSPTRP00000089692	ENSPTRP00000089297	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	annotation not available	0.816
AKT2	FOXO1	ENSPTRP00000089692	ENSPTRP00000009886	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	FOXO1 isoform 1.	0.980
AKT2	INS	ENSPTRP00000089692	ENSPTRP00000077843	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.665
AKT2	NOTCH1	ENSPTRP00000089692	ENSPTRP00000036924	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NOTCH1 isoform 1.	0.407
AKT2	SLC2A2	ENSPTRP00000089692	ENSPTRP00000026876	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.486
AKT3	AKT1	ENSPTRP00000086046	ENSPTRP00000082849	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.951
AKT3	AKT2	ENSPTRP00000086046	ENSPTRP00000089692	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.957