STRINGSTRING
SNW1 SNW1 MAMLD1 MAMLD1 PAX6 PAX6 ONECUT3 ONECUT3 HNF4G HNF4G ONECUT1 ONECUT1 CREBBP CREBBP RFX4 RFX4 INS INS FOXA2 FOXA2 NEUROD2 NEUROD2 ENSPTRP00000089297 ENSPTRP00000089297 ENSPTRP00000087746 ENSPTRP00000087746 HNF4A HNF4A AKT3 AKT3 HNF1A HNF1A NEUROG2 NEUROG2 FGF10 FGF10 PTF1A PTF1A AKT1 AKT1 HNF1B HNF1B ENSPTRP00000082196 ENSPTRP00000082196 ENSPTRP00000081714 ENSPTRP00000081714 MAMLD1-2 MAMLD1-2 ONECUT2 ONECUT2 MAML3 MAML3 RBPJ RBPJ KAT2A KAT2A INSM2 INSM2 NR5A2 NR5A2 NKX6-2 NKX6-2 MAML2 MAML2 IAPP IAPP PDX1 PDX1 FOXO1 FOXO1 NEUROD4 NEUROD4 ENSPTRP00000060300 ENSPTRP00000060300 NEUROG3 NEUROG3 MAML1 MAML1 PKLR PKLR HES4 HES4 GCK GCK HES1 HES1 NOTCH1 NOTCH1 MAFA MAFA PAX4 PAX4 RFX6 RFX6 NEUROG1 NEUROG1 NKX6-1 NKX6-1 SLC2A2 SLC2A2 KAT2B KAT2B EP300 EP300 NKX2-2 NKX2-2 FOXA3 FOXA3 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNW1SNW domain containing 1. (571 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
PAX6PAX6 isoform 13. (436 aa)
ONECUT3One cut domain family member. (472 aa)
HNF4GHNF4G isoform 4. (461 aa)
ONECUT1One cut domain family member. (465 aa)
CREBBPCREB binding protein. (2442 aa)
RFX4Regulatory factor X4. (744 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
FOXA2FOXA2 isoform 1. (464 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
ENSPTRP00000089297annotation not available (265 aa)
ENSPTRP00000087746annotation not available (429 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HNF1AHNF1 homeobox A. (662 aa)
NEUROG2NEUROG2 isoform 1. (272 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
HNF1BHNF1 homeobox B. (557 aa)
ENSPTRP00000082196annotation not available (376 aa)
ENSPTRP00000081714annotation not available (310 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
ONECUT2One cut domain family member. (504 aa)
MAML3MAML3 isoform 1. (1134 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
INSM2INSM transcriptional repressor 2. (568 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
IAPPIslet amyloid polypeptide. (89 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
FOXO1FOXO1 isoform 1. (655 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
ENSPTRP00000060300annotation not available (221 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
MAML1MAML1 isoform 1. (1016 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
GCKPhosphotransferase. (466 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
MAFAMAF bZIP transcription factor A. (348 aa)
PAX4PAX4 isoform 1. (351 aa)
RFX6RFX6 isoform 1. (928 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
EP300E1A binding protein p300. (2175 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
FOXA3FOXA3 isoform 2. (350 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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