42 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB7	Growth factor receptor bound protein 7. (555 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	EFS	Embryonal Fyn-associated substrate. (560 aa)
	STAT5A	Signal transducer and activator of transcription. (783 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	PDGFRA	T0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
	RASA1	RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
	CRKL	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	PDGFA	PDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	ENSPTRP00000067174	annotation not available (502 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	RAPGEF1	RAPGEF1 isoform 5. (1065 aa)
	ENSPTRP00000074763	annotation not available (520 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
	ENSPTRP00000077211	annotation not available (269 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	CRK	V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1198 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1204 aa)
	CASS4	CASS4 isoform 2. (812 aa)
	STAT5B	Signal transducer and activator of transcription. (772 aa)
	ENSPTRP00000089450	annotation not available (303 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	ENSPTRP00000092364	annotation not available (574 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	CRK	ENSPTRP00000079661	ENSPTRP00000083173	BCAR1 scaffold protein, Cas family member.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.999
BCAR1	CRKL	ENSPTRP00000079661	ENSPTRP00000046677	BCAR1 scaffold protein, Cas family member.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.987
BCAR1	ENSPTRP00000089450	ENSPTRP00000079661	ENSPTRP00000089450	BCAR1 scaffold protein, Cas family member.	annotation not available	0.884
BCAR1	GRB2	ENSPTRP00000079661	ENSPTRP00000016382	BCAR1 scaffold protein, Cas family member.	Growth factor receptor-bound protein 2.	0.869
BCAR1	NCK1	ENSPTRP00000079661	ENSPTRP00000026594	BCAR1 scaffold protein, Cas family member.	Cytoplasmic protein.	0.772
BCAR1	NCK2	ENSPTRP00000079661	ENSPTRP00000021097	BCAR1 scaffold protein, Cas family member.	Cytoplasmic protein.	0.506
BCAR1	NEDD9	ENSPTRP00000079661	ENSPTRP00000093102	BCAR1 scaffold protein, Cas family member.	Neural precursor cell expressed, developmentally down-regulated 9.	0.669
BCAR1	PDGFB	ENSPTRP00000079661	ENSPTRP00000024791	BCAR1 scaffold protein, Cas family member.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.470
BCAR1	PDGFRA	ENSPTRP00000079661	ENSPTRP00000027635	BCAR1 scaffold protein, Cas family member.	T0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.501
BCAR1	PDGFRB	ENSPTRP00000079661	ENSPTRP00000080188	BCAR1 scaffold protein, Cas family member.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.555
BCAR1	PIK3R1	ENSPTRP00000079661	ENSPTRP00000076964	BCAR1 scaffold protein, Cas family member.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.442
BCAR1	RAPGEF1	ENSPTRP00000079661	ENSPTRP00000074530	BCAR1 scaffold protein, Cas family member.	RAPGEF1 isoform 5.	0.972
BCAR1	SRC	ENSPTRP00000079661	ENSPTRP00000076797	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.998
CASS4	CRK	ENSPTRP00000089003	ENSPTRP00000083173	CASS4 isoform 2.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.597
CASS4	CRKL	ENSPTRP00000089003	ENSPTRP00000046677	CASS4 isoform 2.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.597
CASS4	EFS	ENSPTRP00000089003	ENSPTRP00000010462	CASS4 isoform 2.	Embryonal Fyn-associated substrate.	0.469
CASS4	ENSPTRP00000089450	ENSPTRP00000089003	ENSPTRP00000089450	CASS4 isoform 2.	annotation not available	0.597
CASS4	PDGFRB	ENSPTRP00000089003	ENSPTRP00000080188	CASS4 isoform 2.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.492
CASS4	RAPGEF1	ENSPTRP00000089003	ENSPTRP00000074530	CASS4 isoform 2.	RAPGEF1 isoform 5.	0.576
CASS4	SRC	ENSPTRP00000089003	ENSPTRP00000076797	CASS4 isoform 2.	Tyrosine-protein kinase.	0.401