STRINGSTRING
COL4A2 COL4A2 NRAS NRAS THBS3 THBS3 HRAS HRAS STAT6 STAT6 EFS EFS FURIN FURIN STAT5A STAT5A GRB2 GRB2 COL5A3 COL5A3 PIK3R2 PIK3R2 CK820_G0041206 CK820_G0041206 NCK2 NCK2 COL3A1 COL3A1 COL4A3 COL4A3 COL6A3 COL6A3 PLCG1 PLCG1 COL9A3 COL9A3 COL6A2 COL6A2 PDGFB PDGFB COL6A6 COL6A6 COL6A5 COL6A5 NCK1 NCK1 PIK3CB PIK3CB PDGFRA PDGFRA THBS4 THBS4 RASA1 RASA1 PLG PLG PTPN12 PTPN12 PLAT PLAT COL2A1 COL2A1 CRKL CRKL COL4A4 COL4A4 COL5A2 COL5A2 PCSK4 PCSK4 SOS1 SOS1 VWA2 VWA2 PDGFA PDGFA PTPN11 PTPN11 ERAS ERAS COL4A5 COL4A5 THBS1 THBS1 ENSPTRP00000067174 ENSPTRP00000067174 CSDE1 CSDE1 GRB7 GRB7 THBS2 THBS2 LOC745271 LOC745271 PTPN11-2 PTPN11-2 RAPGEF1 RAPGEF1 COL5A1 COL5A1 ENSPTRP00000074763 ENSPTRP00000074763 COL9A2 COL9A2 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 PDGFD PDGFD BCAR1 BCAR1 PDGFRB PDGFRB CRK CRK FNDC3A FNDC3A KRAS KRAS PIK3CA PIK3CA FNDC3B FNDC3B CASS4 CASS4 STAT5B STAT5B ENSPTRP00000089450 ENSPTRP00000089450 PDGFC PDGFC STAT1 STAT1 COL4A1 COL4A1 STAT3 STAT3 CK820_G0023028 CK820_G0023028 ENSPTRP00000092364 ENSPTRP00000092364 SPP1 SPP1 NEDD9 NEDD9 COL9A1 COL9A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
THBS3Thrombospondin 3. (956 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
EFSEmbryonal Fyn-associated substrate. (560 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
COL5A3Collagen type V alpha 3 chain. (1745 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CK820_G0041206PLGLB1 isoform 2. (104 aa)
NCK2Cytoplasmic protein. (380 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
COL6A3COL6A3 isoform 2. (3177 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
COL6A2COL6A2 isoform 4. (444 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
COL6A6Collagen, type VI, alpha 6. (2263 aa)
COL6A5COL6A5 isoform 2. (2625 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
THBS4THBS4 isoform 3. (961 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
COL4A4COL4A4 isoform 1. (1690 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
PCSK4PCSK4 isoform 5; Belongs to the peptidase S8 family. (708 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
VWA2VWA2 isoform 1. (755 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ERASES cell expressed Ras. (233 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSPTRP00000067174annotation not available (502 aa)
CSDE1Cold shock domain containing E1. (844 aa)
GRB7Growth factor receptor bound protein 7. (555 aa)
THBS2Thrombospondin 2. (1107 aa)
LOC745271PLGLB1 isoform 1. (150 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
ENSPTRP00000074763annotation not available (520 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
CASS4CASS4 isoform 2. (812 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
ENSPTRP00000089450annotation not available (303 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
CK820_G0023028COL6A2 isoform 1. (417 aa)
ENSPTRP00000092364annotation not available (574 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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