STRINGSTRING
HRAS HRAS SHC4 SHC4 GRB2 GRB2 MAP2K2 MAP2K2 NKPD1 NKPD1 KIDINS220 KIDINS220 MAPK1 MAPK1 MAPKAPK3 MAPKAPK3 MAPK14 MAPK14 RALA RALA RALGDS RALGDS CRKL CRKL SHC1 SHC1 SOS1 SOS1 YWHAB YWHAB MAPK3 MAPK3 MAPK12 MAPK12 MAP2K1 MAP2K1 SHC3 SHC3 ERAS ERAS ENSPTRP00000065064 ENSPTRP00000065064 ENSPTRP00000069037 ENSPTRP00000069037 NGF NGF CSDE1 CSDE1 RALB RALB ENSPTRP00000074059 ENSPTRP00000074059 MAPK11 MAPK11 RAPGEF1 RAPGEF1 ENSPTRP00000074910 ENSPTRP00000074910 RIT2 RIT2 ENSPTRP00000076429 ENSPTRP00000076429 SRC SRC BRAF BRAF MAPK13 MAPK13 CRK CRK NTRK1 NTRK1 KRAS KRAS RAP1A RAP1A BRAF-2 BRAF-2 ENSPTRP00000089450 ENSPTRP00000089450 FRS2 FRS2 ENSPTRP00000090382 ENSPTRP00000090382 NRAS NRAS RIT1 RIT1 MAPKAPK2 MAPKAPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
SHC4SHC adaptor protein 4. (630 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (612 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAPKAPK3Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
RALAV-ral simian leukemia viral oncogene homolog A (Ras related). (206 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (914 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
ERASES cell expressed Ras. (233 aa)
ENSPTRP00000065064annotation not available (405 aa)
ENSPTRP00000069037annotation not available (328 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
CSDE1Cold shock domain containing E1. (844 aa)
RALBV-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein). (212 aa)
ENSPTRP00000074059annotation not available (180 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
ENSPTRP00000074910annotation not available (405 aa)
RIT2Ras like without CAAX 2. (217 aa)
ENSPTRP00000076429annotation not available (110 aa)
SRCTyrosine-protein kinase. (542 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
MAPK13Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] (366 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BRAF-2BRAF isoform 2. (766 aa)
ENSPTRP00000089450annotation not available (303 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
ENSPTRP00000090382annotation not available (493 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
RIT1Ras like without CAAX 1. (236 aa)
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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