STRINGSTRING
NOTCH2 NOTCH2 CREBBP CREBBP LOC107971249-2 LOC107971249-2 LOC471883-2 LOC471883-2 LOC112209457-4 LOC112209457-4 ENSPTRP00000074115 ENSPTRP00000074115 TFDP2 TFDP2 H2BC5 H2BC5 MFNG MFNG AGO3 AGO3 MOV10 MOV10 LOC469702 LOC469702 MAML2 MAML2 H2AFX H2AFX ST3GAL4 ST3GAL4 LOC457262 LOC457262 H2AC7 H2AC7 ATP2A2 ATP2A2 SEL1L SEL1L FURIN FURIN TP53 TP53 KAT2A KAT2A LFNG-2 LFNG-2 SIRT6 SIRT6 NOTCH3 NOTCH3 HIST1H3A HIST1H3A POFUT1 POFUT1 E2F1 E2F1 EP300 EP300 KAT2B KAT2B POGLUT1 POGLUT1 H2AZ1 H2AZ1 HIST1H2BA HIST1H2BA LOC748495 LOC748495 HIST1H2BB HIST1H2BB LOC457262-2 LOC457262-2 LOC462501 LOC462501 H2AC6 H2AC6 ENSPTRP00000093891 ENSPTRP00000093891 RUNX1 RUNX1 ENSPTRP00000092628 ENSPTRP00000092628 H2AC20 H2AC20 LOC471875 LOC471875 H2BC6 H2BC6 ENSPTRP00000090987 ENSPTRP00000090987 E2F1-2 E2F1-2 LOC457262-10 LOC457262-10 ENSPTRP00000089747 ENSPTRP00000089747 ST3GAL6 ST3GAL6 H2BU1 H2BU1 ENSPTRP00000087746 ENSPTRP00000087746 LOC457262-9 LOC457262-9 ENSPTRP00000086173 ENSPTRP00000086173 CCND1 CCND1 LOC462509 LOC462509 H2BC11 H2BC11 H2AC14 H2AC14 H2AFV H2AFV AGO2 AGO2 B4GALT1 B4GALT1 NOTCH1 NOTCH1 LOC107971249 LOC107971249 ATP2A3 ATP2A3 H3F3B H3F3B H2BC14 H2BC14 TNRC6C TNRC6C LOC457262-8 LOC457262-8 CK820_G0031483 CK820_G0031483 ENSPTRP00000084305 ENSPTRP00000084305 RAB6A RAB6A LOC457262-7 LOC457262-7 TMED2 TMED2 ATP2A1 ATP2A1 TFDP1 TFDP1 LFNG LFNG ENSPTRP00000082196 ENSPTRP00000082196 TNRC6B TNRC6B AGO4 AGO4 CRB1 CRB1 TNRC6A TNRC6A TFDP3 TFDP3 H3C13 H3C13 H2BC13 H2BC13 HIST1H2AE HIST1H2AE H2BC21 H2BC21 MAML1 MAML1 NOTCH4 NOTCH4 H2AJ H2AJ LOC107971253 LOC107971253 LOC471907 LOC471907 LOC462508 LOC462508 LOC112209457-2 LOC112209457-2 SNW1 SNW1 LOC104001101 LOC104001101 LOC457262-3 LOC457262-3 MAMLD1 MAMLD1 ENSPTRP00000065421 ENSPTRP00000065421 RFNG RFNG ENSPTRP00000065877 ENSPTRP00000065877 PRKCI PRKCI E2F3 E2F3 LOC746468 LOC746468 LOC471876 LOC471876 LOC457262-4 LOC457262-4 H2AFV-2 H2AFV-2 ENSPTRP00000069899 ENSPTRP00000069899 LOC471880 LOC471880 LOC104001083 LOC104001083 H2BC9 H2BC9 LOC471883 LOC471883 ENSPTRP00000081714 ENSPTRP00000081714 MAMLD1-2 MAMLD1-2 EHF EHF AGO1 AGO1 ST3GAL3 ST3GAL3 MAML3 MAML3 RBPJ RBPJ LOC457262-6 LOC457262-6 LOC107966300 LOC107966300 ENSPTRP00000078054 ENSPTRP00000078054 CK820_G0021556 CK820_G0021556 LOC457262-5 LOC457262-5 ELF3 ELF3 H4C8 H4C8 LOC746430 LOC746430
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
NOTCH2NOTCH2 isoform 1. (2612 aa)
CREBBPCREB binding protein. (2442 aa)
LOC107971249-2Histone H2A-Bbd type 2/3. (115 aa)
LOC471883-2Histone H2B type 1. (126 aa)
LOC112209457-4Histone H3.1. (136 aa)
ENSPTRP00000074115annotation not available (54 aa)
TFDP2Transcription factor. (447 aa)
H2BC5HIST1H2BD isoform 1. (126 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
MOV10Mov10, Moloney leukemia virus 10, homolog. (1005 aa)
LOC469702Histone H2B type 3-A. (126 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
H2AFXH2AFX isoform 1. (143 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Belongs to the glycosyltransferase 29 family. (341 aa)
LOC457262HIST1H4A isoform 1. (103 aa)
H2AC7Histone H2A type 1-D. (130 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
LFNG-2LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (242 aa)
SIRT6SIRT6 isoform 1. (355 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
HIST1H3AH3F3B isoform 13. (136 aa)
POFUT1GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (388 aa)
E2F1E2F transcription factor 1. (437 aa)
EP300E1A binding protein p300. (2175 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
H2AZ1H2AFZ isoform 3. (128 aa)
HIST1H2BAHIST1H2BA isoform 1. (127 aa)
LOC748495HIST1H2AB isoform 1. (130 aa)
HIST1H2BBHIST1H2BB isoform 1. (126 aa)
LOC457262-2Histone H4. (103 aa)
LOC462501HIST1H2BK isoform 1. (126 aa)
H2AC6HIST1H2AC isoform 1. (130 aa)
ENSPTRP00000093891annotation not available (281 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSPTRP00000092628annotation not available (129 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC471875Histone H3.1-like. (136 aa)
H2BC6Histone H2B type 1. (126 aa)
ENSPTRP00000090987annotation not available (87 aa)
E2F1-2E2F transcription factor 1. (437 aa)
LOC457262-10Histone H4. (103 aa)
ENSPTRP00000089747annotation not available (156 aa)
ST3GAL6Type 2 lactosamine alpha-2,3-sialyltransferase; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Belongs to the glycosyltransferase 29 family. (384 aa)
H2BU1HIST3H2BB isoform 1. (126 aa)
ENSPTRP00000087746annotation not available (429 aa)
LOC457262-9Histone H4. (103 aa)
ENSPTRP00000086173annotation not available (566 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
LOC462509HIST1H2BO isoform 1. (126 aa)
H2BC11HIST1H2BJ isoform 1. (126 aa)
H2AC14HIST1H2AJ isoform 1. (128 aa)
H2AFVH2AFV isoform 6. (128 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
B4GALT1UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1. (398 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LOC107971249Histone H2A; Belongs to the histone H2A family. (115 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1052 aa)
H3F3BH3 histone family member 3B. (136 aa)
H2BC14HIST1H2BM isoform 1. (126 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1943 aa)
LOC457262-8Histone H4. (103 aa)
CK820_G0031483H2AFV isoform 8. (118 aa)
ENSPTRP00000084305annotation not available (104 aa)
RAB6ARAB6A, member RAS oncogene family. (208 aa)
LOC457262-7Histone H4. (103 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa)
TFDP1Transcription factor. (352 aa)
LFNGLFNG isoform 5. (405 aa)
ENSPTRP00000082196annotation not available (376 aa)
TNRC6BTNRC6B isoform 2. (1832 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
TNRC6ATNRC6A isoform 3. (1937 aa)
TFDP3Transcription factor. (405 aa)
H3C13HIST2H3A isoform 1. (136 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2AEHistone cluster 1 H2A family member e. (130 aa)
H2BC21HIST2H2BE isoform 1. (126 aa)
MAML1MAML1 isoform 1. (1016 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
H2AJH2AFJ isoform 2. (129 aa)
LOC107971253Histone H2A-Bbd type 2/3. (115 aa)
LOC471907Histone H3.1. (104 aa)
LOC462508Histone H2B type 1-N. (167 aa)
LOC112209457-2Histone H3.1. (136 aa)
SNW1SNW domain containing 1. (571 aa)
LOC104001101Histone H3.1. (136 aa)
LOC457262-3Histone H4. (103 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
ENSPTRP00000065421annotation not available (120 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (333 aa)
ENSPTRP00000065877annotation not available (115 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
E2F3E2F transcription factor 3. (465 aa)
LOC746468HIST2H2AA3 isoform 1. (130 aa)
LOC471876Histone H3.1. (136 aa)
LOC457262-4Histone H4. (103 aa)
H2AFV-2H2A histone family member V. (127 aa)
ENSPTRP00000069899annotation not available (273 aa)
LOC471880Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104001083Histone H3.1. (136 aa)
H2BC9HIST1H2BH isoform 1. (126 aa)
LOC471883Histone H2B type 1. (126 aa)
ENSPTRP00000081714annotation not available (310 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
EHFETS homologous factor; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). (322 aa)
AGO1Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. (860 aa)
ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta- 1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. (444 aa)
MAML3MAML3 isoform 1. (1134 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LOC457262-6Histone H4. (103 aa)
LOC107966300Histone H3. (136 aa)
ENSPTRP00000078054annotation not available (132 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
LOC457262-5Histone H4. (103 aa)
ELF3E74 like ETS transcription factor 3. (375 aa)
H4C8Histone H4. (103 aa)
LOC746430Uncharacterized LOC746430. (136 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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