STRINGSTRING
ENSPTRP00000071568 ENSPTRP00000071568 HES4 HES4 TLE2 TLE2 LRBA LRBA DNER DNER HDAC2 HDAC2 UBC UBC PSEN2 PSEN2 ADAM17 ADAM17 MIB1 MIB1 NCSTN NCSTN HEYL HEYL HDAC7 HDAC7 NCOR2 NCOR2 ENSPTRP00000088150 ENSPTRP00000088150 TBL1Y TBL1Y ENSPTRP00000087746 ENSPTRP00000087746 NEURL1B NEURL1B ENSPTRP00000086422 ENSPTRP00000086422 CUL1-2 CUL1-2 HDAC11 HDAC11 MAML2 MAML2 DTX1 DTX1 CDK8 CDK8 HIF1A HIF1A PSEN1 PSEN1 ADAM10 ADAM10 APH1B APH1B TLE3 TLE3 ARRB2 ARRB2 KAT2A KAT2A HDAC5 HDAC5 PSENEN PSENEN RPS27A RPS27A JAG1 JAG1 DTX4 DTX4 RBX1 RBX1 KXD1 KXD1 MAML1 MAML1 CK820_G0055465 CK820_G0055465 CUL1 CUL1 NOTCH1 NOTCH1 ENSPTRP00000060300 ENSPTRP00000060300 HDAC6 HDAC6 HES5 HES5 ITCH ITCH ARRB1 ARRB1 APH1A APH1A TLE1 TLE1 NUMB NUMB ENSPTRP00000060412 ENSPTRP00000060412 CK820_G0056543 CK820_G0056543 MIB2 MIB2 HES1 HES1 SNW1 SNW1 ENSPTRP00000064916 ENSPTRP00000064916 MAMLD1 MAMLD1 LOC748850 LOC748850 ENSPTRP00000067263 ENSPTRP00000067263 TBL1X TBL1X HEY1 HEY1 SKP1 SKP1 DLL4 DLL4 ENSPTRP00000071372 ENSPTRP00000071372 TLE4 TLE4 ENSPTRP00000071907 ENSPTRP00000071907 NBEA NBEA HDAC4 HDAC4 CREBBP CREBBP CK820_G0016908 CK820_G0016908 CNTN1 CNTN1 NCOR1 NCOR1 MYC MYC HDAC1 HDAC1 JAG2 JAG2 CK820_G0051198 CK820_G0051198 RBPJ RBPJ MAML3 MAML3 DLK1 DLK1 HES5-2 HES5-2 MAMLD1-2 MAMLD1-2 ENSPTRP00000081714 ENSPTRP00000081714 TBL1XR1 TBL1XR1 ENSPTRP00000082196 ENSPTRP00000082196 DTX2 DTX2 HDAC9 HDAC9 DLL1 DLL1 HEY2 HEY2 CCNC CCNC HDAC3 HDAC3 FBXW7 FBXW7 KAT2B KAT2B HDAC10 HDAC10 EP300 EP300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000071568annotation not available (98 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
TLE2Transducin-like enhancer of split 2. (716 aa)
LRBALRBA isoform 8. (747 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
ADAM17ADAM17 isoform 3. (999 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
NCSTNNCSTN isoform 1. (721 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
ENSPTRP00000088150annotation not available (75 aa)
TBL1YTBL1X isoform 5. (533 aa)
ENSPTRP00000087746annotation not available (429 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (558 aa)
ENSPTRP00000086422annotation not available (590 aa)
CUL1-2Cullin 1. (776 aa)
HDAC11HDAC11 isoform 14. (374 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
DTX1Deltex E3 ubiquitin ligase 1. (620 aa)
CDK8Cyclin-dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
TLE3TLE family member 3, transcriptional corepressor. (782 aa)
ARRB2ARRB2 isoform 2. (430 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
PSENENT0105581 isoform 1. (101 aa)
RPS27ARPS27A isoform 1. (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
KXD1UBA52 isoform 10. (231 aa)
MAML1MAML1 isoform 1. (1016 aa)
CK820_G0055465RING-type domain-containing protein. (511 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENSPTRP00000060300annotation not available (221 aa)
HDAC6Histone deacetylase 6. (146 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ARRB1ARRB1 isoform 1. (418 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
TLE1Transducin-like enhancer of split 1. (814 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
ENSPTRP00000060412annotation not available (156 aa)
CK820_G0056543DTX2P1-UPK3BP1-PMS2P11 isoform 2. (590 aa)
MIB2Mindbomb homolog 2. (991 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SNW1SNW domain containing 1. (571 aa)
ENSPTRP00000064916annotation not available (631 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
LOC748850HDAC2 isoform 9. (445 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
TBL1XTransducin (Beta)-like 1X-linked. (571 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ENSPTRP00000071372annotation not available (243 aa)
TLE4TLE family member 4, transcriptional corepressor. (805 aa)
ENSPTRP00000071907annotation not available (164 aa)
NBEANBEA isoform 7. (2947 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
CREBBPCREB binding protein. (2442 aa)
CK820_G0016908LRBA isoform 14. (265 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
CK820_G0051198TLE2 isoform 3. (113 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MAML3MAML3 isoform 1. (1134 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
ENSPTRP00000081714annotation not available (310 aa)
TBL1XR1Transducin (Beta)-like 1 X-linked receptor 1. (562 aa)
ENSPTRP00000082196annotation not available (376 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
CCNCCCNC isoform 1; Belongs to the cyclin family. (283 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
HDAC10Histone deacetylase 10. (669 aa)
EP300E1A binding protein p300. (2175 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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