STRINGSTRING
PLD3 PLD3 MYO1D MYO1D LIMK1 LIMK1 ENSPTRP00000092307 ENSPTRP00000092307 ACTR2 ACTR2 ENSPTRP00000091771 ENSPTRP00000091771 WAS-2 WAS-2 ENSPTRP00000091405 ENSPTRP00000091405 ENSPTRP00000090995 ENSPTRP00000090995 YES1 YES1 VAV3 VAV3 MYO1C MYO1C ARPC2 ARPC2 ENSPTRP00000089740 ENSPTRP00000089740 ENSPTRP00000089530 ENSPTRP00000089530 ENSPTRP00000089430 ENSPTRP00000089430 LOC107968084 LOC107968084 ENSPTRP00000088414 ENSPTRP00000088414 MYO1H MYO1H CK820_G0052139 CK820_G0052139 CFL1 CFL1 ENSPTRP00000086478 ENSPTRP00000086478 ENSPTRP00000085830 ENSPTRP00000085830 ENSPTRP00000085718 ENSPTRP00000085718 ENSPTRP00000085141 ENSPTRP00000085141 ENSPTRP00000084862 ENSPTRP00000084862 PIK3CA PIK3CA ARPC4 ARPC4 RAC1-2 RAC1-2 VAV2 VAV2 PTK2 PTK2 CK820_G0012542 CK820_G0012542 CRK CRK MYO1B MYO1B ENSPTRP00000081707 ENSPTRP00000081707 ENSPTRP00000081694 ENSPTRP00000081694 PLPP5 PLPP5 ENSPTRP00000081537 ENSPTRP00000081537 ENSPTRP00000080740 ENSPTRP00000080740 ACTG1 ACTG1 MYO5A MYO5A LIMK1-2 LIMK1-2 MYO1G-2 MYO1G-2 ENSPTRP00000079105 ENSPTRP00000079105 MYH9 MYH9 ENSPTRP00000078893 ENSPTRP00000078893 CK820_G0052121 CK820_G0052121 ENSPTRP00000078387 ENSPTRP00000078387 CK820_G0023066 CK820_G0023066 CK820_G0055030 CK820_G0055030 ENSPTRP00000077947 ENSPTRP00000077947 CDC42 CDC42 FYN FYN ENSPTRP00000077428 ENSPTRP00000077428 PIK3R1 PIK3R1 CK820_G0024813 CK820_G0024813 SRC SRC LOC101057895 LOC101057895 PLCG2 PLCG2 WIPF1 WIPF1 SYK SYK ARPC3 ARPC3 ABI2 ABI2 ABL1 ABL1 CK820_G0056252 CK820_G0056252 FMN2 FMN2 CK820_G0054782 CK820_G0054782 ENSPTRP00000072507 ENSPTRP00000072507 NF2 NF2 ELMO1 ELMO1 ENSPTRP00000072166 ENSPTRP00000072166 HSP90AA1 HSP90AA1 ENSPTRP00000070878 ENSPTRP00000070878 ENSPTRP00000070755 ENSPTRP00000070755 ENSPTRP00000070693 ENSPTRP00000070693 RAC1 RAC1 WAS WAS ENSPTRP00000067835 ENSPTRP00000067835 ENSPTRP00000066583 ENSPTRP00000066583 AHCYL1 AHCYL1 ENSPTRP00000066220 ENSPTRP00000066220 ENSPTRP00000065882 ENSPTRP00000065882 LOC744594 LOC744594 PLPP4 PLPP4 BAIAP2 BAIAP2 ENSPTRP00000064849 ENSPTRP00000064849 CYFIP2 CYFIP2 ACTR3C ACTR3C WIPF2 WIPF2 FMN1 FMN1 PLD5 PLD5 ENSPTRP00000062610 ENSPTRP00000062610 CK820_G0052128 CK820_G0052128 MYO9B MYO9B CK820_G0012168 CK820_G0012168 PLD4 PLD4 IGLL5 IGLL5 LOC452776 LOC452776 CK820_G0055106 CK820_G0055106 CK820_G0055055 CK820_G0055055 ACTL9 ACTL9 ACTB ACTB ELMO3 ELMO3 CK820_G0015929 CK820_G0015929 IGKV1D-43 IGKV1D-43 MAPK3 MAPK3 LOC456647 LOC456647 ENSPTRP00000050833 ENSPTRP00000050833 LYN LYN LOC744297 LOC744297 WASF1 WASF1 ABI1 ABI1 CD247 CD247 PLD1 PLD1 MYO1G MYO1G FCGR2A FCGR2A CK820_G0052109 CK820_G0052109 WASF3 WASF3 ACTRT1 ACTRT1 BTK BTK ARPC5L ARPC5L ACTL7A ACTL7A ACTL7B ACTL7B CK820_G0053598 CK820_G0053598 ACTR3B ACTR3B WASL WASL ARPC1B ARPC1B ARPC1A ARPC1A WIPF3 WIPF3 HSP90AB1 HSP90AB1 ITPR3 ITPR3 MYO10 MYO10 PIK3CB PIK3CB NCK1 NCK1 PRKCD PRKCD NCKIPSD NCKIPSD BRK1 BRK1 ITPR1 ITPR1 ITPR2 ITPR2 PLA2G6 PLA2G6 MAPK1 MAPK1 CK820_G0046006 CK820_G0046006 ELMO2 ELMO2 PLCG1 PLCG1 HCK HCK DSTN DSTN NCKAP1 NCKAP1 PRKCE PRKCE PIK3R2 PIK3R2 VAV1 VAV1 ENSPTRP00000016618 ENSPTRP00000016618 GRB2 GRB2 MYH2 MYH2 PLD2 PLD2 MYO5C MYO5C CYFIP1 CYFIP1 CFL2 CFL2 MYO1A MYO1A NCKAP1L NCKAP1L CD3G CD3G PAK1 PAK1 DOCK1 DOCK1 CK820_G0023253 CK820_G0023253 ARPC5 ARPC5 FCGR1A FCGR1A FGR FGR ENSPTRP00000000715 ENSPTRP00000000715 WASF2 WASF2 ACTL8 ACTL8 ACTRT2 ACTRT2 ENSPTRP00000093517 ENSPTRP00000093517 LOC461365 LOC461365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD3Phospholipase D family, member 3. (490 aa)
MYO1DMYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
LIMK1LIM domain kinase 1. (677 aa)
ENSPTRP00000092307annotation not available (161 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ENSPTRP00000091771annotation not available (149 aa)
WAS-2WASP actin nucleation promoting factor. (502 aa)
ENSPTRP00000091405annotation not available (334 aa)
ENSPTRP00000090995annotation not available (206 aa)
YES1Tyrosine-protein kinase. (558 aa)
VAV3VAV3 isoform 2. (927 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
ENSPTRP00000089740annotation not available (123 aa)
ENSPTRP00000089530annotation not available (141 aa)
ENSPTRP00000089430annotation not available (189 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
ENSPTRP00000088414annotation not available (529 aa)
MYO1HMYO1H isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1038 aa)
CK820_G0052139IGLV2-23 isoform 1. (170 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
ENSPTRP00000086478annotation not available (333 aa)
ENSPTRP00000085830annotation not available (168 aa)
ENSPTRP00000085718annotation not available (180 aa)
ENSPTRP00000085141annotation not available (333 aa)
ENSPTRP00000084862annotation not available (154 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X4. (173 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
CK820_G0012542ACTR3 isoform 5. (34 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
MYO1BMYO1B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
ENSPTRP00000081707annotation not available (149 aa)
ENSPTRP00000081694annotation not available (182 aa)
PLPP5Phosphatidic acid phosphatase type 2 domain containing 1B. (264 aa)
ENSPTRP00000081537annotation not available (449 aa)
ENSPTRP00000080740annotation not available (150 aa)
ACTG1ACTG1 isoform 13. (375 aa)
MYO5AMYO5A isoform 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1877 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
MYO1G-2Myosin IG. (1018 aa)
ENSPTRP00000079105annotation not available (149 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ENSPTRP00000078893annotation not available (168 aa)
CK820_G0052121IGLV3-10 isoform 1. (148 aa)
ENSPTRP00000078387annotation not available (202 aa)
CK820_G0023066ACTA1 isoform 2. (150 aa)
CK820_G0055030IGHV1-2 isoform 1. (159 aa)
ENSPTRP00000077947annotation not available (48 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSPTRP00000077428annotation not available (202 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CK820_G0024813HSP90AA1 isoform 6. (367 aa)
SRCTyrosine-protein kinase. (542 aa)
LOC101057895Heat shock protein HSP 90-alpha pseudogene. (670 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
WIPF1WAS/WASL interacting protein family, member 1. (554 aa)
SYKTyrosine-protein kinase. (635 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ABI2Abl interactor 2. (513 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CK820_G0056252IGHV3-30 isoform 1. (198 aa)
FMN2FMN2 isoform 6. (198 aa)
CK820_G0054782IGLV9-49 isoform 1. (123 aa)
ENSPTRP00000072507annotation not available (659 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
ELMO1Engulfment and cell motility 1. (769 aa)
ENSPTRP00000072166annotation not available (318 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
ENSPTRP00000070878annotation not available (324 aa)
ENSPTRP00000070755annotation not available (81 aa)
ENSPTRP00000070693annotation not available (228 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
WASWAS isoform 1. (502 aa)
ENSPTRP00000067835annotation not available (192 aa)
ENSPTRP00000066583annotation not available (181 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
ENSPTRP00000066220annotation not available (211 aa)
ENSPTRP00000065882annotation not available (152 aa)
LOC744594IGHV4-61 isoform 1. (215 aa)
PLPP4Phosphatidic acid phosphatase type 2 domain containing 1A. (273 aa)
BAIAP2BAI1 associated protein 2. (553 aa)
ENSPTRP00000064849annotation not available (150 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ACTR3CActin-related protein 3C isoform X1. (239 aa)
WIPF2WAS/WASL interacting protein family, member 2. (440 aa)
FMN1FMN1 isoform 1. (1425 aa)
PLD5Phospholipase D family member 5. (536 aa)
ENSPTRP00000062610annotation not available (279 aa)
CK820_G0052128IGLV2-14 isoform 1. (170 aa)
MYO9BLOW QUALITY PROTEIN: unconventional myosin-IXb. (1987 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
PLD4Phospholipase D family member 4. (513 aa)
IGLL5IGLL5 isoform 1. (215 aa)
LOC452776TRAV22 isoform 1. (185 aa)
CK820_G0055106IGHV3-66 isoform 1. (181 aa)
CK820_G0055055IGHV2-26 isoform 1. (178 aa)
ACTL9ACTL9 isoform 1; Belongs to the actin family. (416 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ELMO3Engulfment and cell motility 3. (773 aa)
CK820_G0015929ARPC3 isoform 3. (178 aa)
IGKV1D-43IGKV1-39 isoform 1. (125 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC456647WASHC1 isoform 1. (323 aa)
ENSPTRP00000050833annotation not available (151 aa)
LYNTyrosine-protein kinase. (512 aa)
LOC744297POTE ankyrin domain family member G-like. (956 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
ABI1Abl interactor 1. (508 aa)
CD247CD247 isoform 2. (163 aa)
PLD1Phospholipase. (1074 aa)
MYO1GMYO1G isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1018 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa)
CK820_G0052109IGLV3-1 isoform 1. (166 aa)
WASF3WH2 domain-containing protein. (502 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (376 aa)
BTKBTK isoform 2. (693 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ACTL7AActin-like protein 7A; Belongs to the actin family. (435 aa)
ACTL7BActin-like protein 7B; Belongs to the actin family. (415 aa)
CK820_G0053598POTEJ isoform 1; Belongs to the actin family. (1078 aa)
ACTR3BARP3 actin-related protein 3 homolog B; Belongs to the actin family. (418 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ARPC1BActin related protein 2/3 complex, subunit 1A/1B. (372 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
WIPF3WAS/WASL interacting protein family member 3. (483 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MYO10MYO10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NCK1Cytoplasmic protein. (377 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
NCKIPSDNCK interacting protein with SH3 domain. (722 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CK820_G0046006IGKV2-40 isoform 1. (122 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
HCKTyrosine-protein kinase. (526 aa)
DSTNDestrin (Actin depolymerizing factor); Belongs to the actin-binding proteins ADF family. (165 aa)
NCKAP1Nck-associated protein 1. (1128 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ENSPTRP00000016618Actin beta like 2. (375 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MYH2MYH2 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
PLD2Phospholipase. (933 aa)
MYO5CMYO5C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
MYO1AMYO1A isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
CD3GCD3G isoform 1. (182 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
DOCK1DOCK1 isoform 1; Belongs to the DOCK family. (1854 aa)
CK820_G0023253FMN2 isoform 2. (1196 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
FCGR1AFCGR1A isoform 2. (373 aa)
FGRTyrosine-protein kinase. (529 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
WASF2WAS protein family, member 2. (498 aa)
ACTL8ACTL8 isoform 1; Belongs to the actin family. (366 aa)
ACTRT2ACTRT2 isoform 1; Belongs to the actin family. (377 aa)
ENSPTRP00000093517annotation not available (149 aa)
LOC461365Heat shock protein HSP 90-beta pseudogene. (584 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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