STRINGSTRING
KAT2B KAT2B NCOR2 NCOR2 HDAC7 HDAC7 HEYL HEYL MAML2 MAML2 CDK8 CDK8 HIF1A HIF1A TLE3 TLE3 KAT2A KAT2A HDAC5 HDAC5 RPS27A RPS27A RBX1 RBX1 EP300 EP300 HDAC10 HDAC10 FBXW7 FBXW7 HDAC3 HDAC3 CCNC CCNC HEY2 HEY2 HDAC9 HDAC9 CUL1 CUL1 NOTCH1 NOTCH1 HDAC6 HDAC6 HES5 HES5 TLE1 TLE1 HES4 HES4 TLE2 TLE2 LRBA LRBA HDAC2 HDAC2 UBC UBC MAML1 MAML1 HDAC11 HDAC11 CUL1-2 CUL1-2 ENSPTRP00000087746 ENSPTRP00000087746 TBL1Y TBL1Y ENSPTRP00000088150 ENSPTRP00000088150 KXD1 KXD1 ENSPTRP00000060300 ENSPTRP00000060300 ENSPTRP00000060412 ENSPTRP00000060412 HES1 HES1 SNW1 SNW1 ENSPTRP00000064916 ENSPTRP00000064916 MAMLD1 MAMLD1 LOC748850 LOC748850 TBL1X TBL1X HEY1 HEY1 SKP1 SKP1 ENSPTRP00000071372 ENSPTRP00000071372 TLE4 TLE4 ENSPTRP00000071907 ENSPTRP00000071907 NBEA NBEA HDAC4 HDAC4 CREBBP CREBBP CK820_G0016908 CK820_G0016908 NCOR1 NCOR1 MYC MYC HDAC1 HDAC1 CK820_G0051198 CK820_G0051198 RBPJ RBPJ MAML3 MAML3 HES5-2 HES5-2 MAMLD1-2 MAMLD1-2 ENSPTRP00000081714 ENSPTRP00000081714 TBL1XR1 TBL1XR1 ENSPTRP00000082196 ENSPTRP00000082196
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
CDK8Cyclin-dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TLE3TLE family member 3, transcriptional corepressor. (782 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
RPS27ARPS27A isoform 1. (156 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
EP300E1A binding protein p300. (2175 aa)
HDAC10Histone deacetylase 10. (669 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CCNCCCNC isoform 1; Belongs to the cyclin family. (283 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HDAC6Histone deacetylase 6. (146 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
TLE1Transducin-like enhancer of split 1. (814 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
TLE2Transducin-like enhancer of split 2. (716 aa)
LRBALRBA isoform 8. (747 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
MAML1MAML1 isoform 1. (1016 aa)
HDAC11HDAC11 isoform 14. (374 aa)
CUL1-2Cullin 1. (776 aa)
ENSPTRP00000087746annotation not available (429 aa)
TBL1YTBL1X isoform 5. (533 aa)
ENSPTRP00000088150annotation not available (75 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060300annotation not available (221 aa)
ENSPTRP00000060412annotation not available (156 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SNW1SNW domain containing 1. (571 aa)
ENSPTRP00000064916annotation not available (631 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
LOC748850HDAC2 isoform 9. (445 aa)
TBL1XTransducin (Beta)-like 1X-linked. (571 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
ENSPTRP00000071372annotation not available (243 aa)
TLE4TLE family member 4, transcriptional corepressor. (805 aa)
ENSPTRP00000071907annotation not available (164 aa)
NBEANBEA isoform 7. (2947 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
CREBBPCREB binding protein. (2442 aa)
CK820_G0016908LRBA isoform 14. (265 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CK820_G0051198TLE2 isoform 3. (113 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MAML3MAML3 isoform 1. (1134 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
ENSPTRP00000081714annotation not available (310 aa)
TBL1XR1Transducin (Beta)-like 1 X-linked receptor 1. (562 aa)
ENSPTRP00000082196annotation not available (376 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.