STRINGSTRING
DTX4 DTX4 DTX1 DTX1 PSEN1 PSEN1 ADAM10 ADAM10 APH1B APH1B ARRB2 ARRB2 PSENEN PSENEN RPS27A RPS27A JAG1 JAG1 DLL1 DLL1 DTX2 DTX2 CK820_G0055465 CK820_G0055465 NOTCH1 NOTCH1 ITCH ITCH ARRB1 ARRB1 APH1A APH1A NUMB NUMB DNER DNER UBC UBC PSEN2 PSEN2 ADAM17 ADAM17 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 CK820_G0056543 CK820_G0056543 MIB2 MIB2 ENSPTRP00000067263 ENSPTRP00000067263 DLL4 DLL4 ENSPTRP00000071568 ENSPTRP00000071568 CNTN1 CNTN1 JAG2 JAG2 DLK1 DLK1 ENSPTRP00000086422 ENSPTRP00000086422 NEURL1B NEURL1B NCSTN NCSTN MIB1 MIB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
DTX1Deltex E3 ubiquitin ligase 1. (620 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ARRB2ARRB2 isoform 2. (430 aa)
PSENENT0105581 isoform 1. (101 aa)
RPS27ARPS27A isoform 1. (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
CK820_G0055465RING-type domain-containing protein. (511 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ARRB1ARRB1 isoform 1. (418 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
ADAM17ADAM17 isoform 3. (999 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
CK820_G0056543DTX2P1-UPK3BP1-PMS2P11 isoform 2. (590 aa)
MIB2Mindbomb homolog 2. (991 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ENSPTRP00000071568annotation not available (98 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
ENSPTRP00000086422annotation not available (590 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (558 aa)
NCSTNNCSTN isoform 1. (721 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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