STRINGSTRING
ZFYVE9 ZFYVE9 TGFB2 TGFB2 BAMBI BAMBI LTBP3 LTBP3 CBL CBL PPP1CA PPP1CA TGFB3 TGFB3 FURIN FURIN STUB1 STUB1 MTMR4 MTMR4 SMAD7 SMAD7 SMAD4 SMAD4 LTBP4 LTBP4 TGFB1 TGFB1 PPP1R15A PPP1R15A RPS27A RPS27A FKBP1A FKBP1A XPO1 XPO1 LTBP1 LTBP1 SMURF1 SMURF1 UBE2M UBE2M ITGAV ITGAV PCSK4 PCSK4 UBC UBC ITGB5 ITGB5 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 SMAD2 SMAD2 NEDD4L NEDD4L LTBP2 LTBP2 ENSPTRP00000067263 ENSPTRP00000067263 ENSPTRP00000067636 ENSPTRP00000067636 FBN1 FBN1 ITGB3 ITGB3 PPP1CB PPP1CB ITGB1 ITGB1 ENSPTRP00000069894 ENSPTRP00000069894 PMEPA1 PMEPA1 ENSPTRP00000071568 ENSPTRP00000071568 TGFBR1 TGFBR1 USP15 USP15 ITGB6 ITGB6 PPP1CC-2 PPP1CC-2 TGFBR2 TGFBR2 ENSPTRP00000075516 ENSPTRP00000075516 STRAP STRAP ENSPTRP00000077224 ENSPTRP00000077224 PPP1CC PPP1CC ENSPTRP00000078047 ENSPTRP00000078047 ENSPTRP00000080278 ENSPTRP00000080278 ENSPTRP00000081587 ENSPTRP00000081587 LDLRAD4 LDLRAD4 ITGB8 ITGB8 ENSPTRP00000084393 ENSPTRP00000084393 ITGB8-2 ITGB8-2 ITGA8 ITGA8 ENSPTRP00000086815 ENSPTRP00000086815 SMURF2 SMURF2 NEDD8 NEDD8 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPP1R15APPP1R15A isoform 1. (682 aa)
RPS27ARPS27A isoform 1. (156 aa)
FKBP1APeptidylprolyl isomerase. (139 aa)
XPO1XPO1 isoform 1. (1071 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
PCSK4PCSK4 isoform 5; Belongs to the peptidase S8 family. (708 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
ENSPTRP00000067636annotation not available (84 aa)
FBN1FBN1 isoform 1. (2871 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSPTRP00000069894annotation not available (299 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
ENSPTRP00000071568annotation not available (98 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ITGB6ITGB6 isoform 3. (701 aa)
PPP1CC-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ENSPTRP00000075516annotation not available (322 aa)
STRAPSerine/threonine kinase receptor associated protein. (363 aa)
ENSPTRP00000077224annotation not available (84 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
ENSPTRP00000078047annotation not available (132 aa)
ENSPTRP00000080278annotation not available (136 aa)
ENSPTRP00000081587annotation not available (103 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
ENSPTRP00000084393annotation not available (72 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ENSPTRP00000086815annotation not available (145 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
NEDD8Ubiquitin-like protein Nedd8. (81 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.