STRINGSTRING
ATP1B4 ATP1B4 STAT1 STAT1 SMAD3 SMAD3 NCOR2 NCOR2 SMURF2 SMURF2 ENSPTRP00000086815 ENSPTRP00000086815 CDKN2B CDKN2B TFDP1 TFDP1 ENSPTRP00000081714 ENSPTRP00000081714 ENSPTRP00000080278 ENSPTRP00000080278 LOC452975 LOC452975 E2F4 E2F4 ENSPTRP00000078565 ENSPTRP00000078565 ENSPTRP00000078047 ENSPTRP00000078047 ENSPTRP00000077224 ENSPTRP00000077224 YBX1 YBX1 ENSPTRP00000076001 ENSPTRP00000076001 HDAC1 HDAC1 MYC MYC NCOR1 NCOR1 CK820_G0036339 CK820_G0036339 LOC104004819 LOC104004819 IRX4 IRX4 CCNQ CCNQ TFDP2 TFDP2 MEIS3 MEIS3 ENSPTRP00000071568 ENSPTRP00000071568 SKIL SKIL USP9X USP9X ENSPTRP00000068134 ENSPTRP00000068134 ENSPTRP00000067636 ENSPTRP00000067636 IRX5 IRX5 ENSPTRP00000067263 ENSPTRP00000067263 LOC748850 LOC748850 LOC747903 LOC747903 CCNK CCNK ENSPTRP00000065877 ENSPTRP00000065877 SNW1 SNW1 ENSPTRP00000063212 ENSPTRP00000063212 NEDD4L NEDD4L SMAD2 SMAD2 SKI SKI TRIM33 TRIM33 PARP1 PARP1 MKX MKX UBE2D1 UBE2D1 MEN1 MEN1 CCNT1 CCNT1 SP1 SP1 CDK8 CDK8 PPM1A PPM1A RNF111 RNF111 FURIN FURIN IRX3 IRX3 IRX6 IRX6 TGIF1 TGIF1 SMAD7 SMAD7 SMAD4 SMAD4 RPS27A RPS27A TGIF2 TGIF2 RBL1 RBL1 MAPK1 MAPK1 EP300 EP300 IRX2 IRX2 IRX1 IRX1 CCNC CCNC COL1A2 COL1A2 SERPINE1 SERPINE1 E2F5 E2F5 CDK9 CDK9 TGIF2LX TGIF2LX USP9Y USP9Y CCNT2 CCNT2 WWTR1 WWTR1 TFDP3 TFDP3 JUNB JUNB PCSK4 PCSK4 UBC UBC MAPK3 MAPK3 CK820_G0025516 CK820_G0025516 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
ENSPTRP00000086815annotation not available (145 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
TFDP1Transcription factor. (352 aa)
ENSPTRP00000081714annotation not available (310 aa)
ENSPTRP00000080278annotation not available (136 aa)
LOC452975Nuclease-sensitive element-binding protein 1 pseudogene. (328 aa)
E2F4E2F transcription factor 4, p107/p130-binding. (414 aa)
ENSPTRP00000078565annotation not available (328 aa)
ENSPTRP00000078047annotation not available (132 aa)
ENSPTRP00000077224annotation not available (84 aa)
YBX1YBX1 isoform 3. (295 aa)
ENSPTRP00000076001annotation not available (125 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
CK820_G0036339TFDP1 isoform 5. (370 aa)
LOC104004819Nuclease-sensitive element-binding protein 1 pseudogene. (315 aa)
IRX4IRX4 isoform 3. (543 aa)
CCNQFamily with sequence similarity 58, member A; Belongs to the cyclin family. (248 aa)
TFDP2Transcription factor. (447 aa)
MEIS3MEIS3 isoform 5. (463 aa)
ENSPTRP00000071568annotation not available (98 aa)
SKILSKI like proto-oncogene. (684 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
ENSPTRP00000068134annotation not available (255 aa)
ENSPTRP00000067636annotation not available (84 aa)
IRX5Iroquois homeobox 5. (483 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
LOC748850HDAC2 isoform 9. (445 aa)
LOC747903Nuclease-sensitive element-binding protein 1 pseudogene. (306 aa)
CCNKCCNK isoform 2; Belongs to the cyclin family. (572 aa)
ENSPTRP00000065877annotation not available (115 aa)
SNW1SNW domain containing 1. (571 aa)
ENSPTRP00000063212annotation not available (75 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
MKXMohawk homeobox. (352 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
MEN1MEN1 isoform 14. (615 aa)
CCNT1Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)
SP1Sp1 transcription factor. (786 aa)
CDK8Cyclin-dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
RNF111RNF111 isoform 5. (1003 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
IRX3Iroquois homeobox 3. (500 aa)
IRX6Iroquois homeobox 6. (445 aa)
TGIF1Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activitie [...] (401 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RPS27ARPS27A isoform 1. (156 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
EP300E1A binding protein p300. (2175 aa)
IRX2Iroquois homeobox 2. (471 aa)
IRX1Iroquois homeobox 1. (480 aa)
CCNCCCNC isoform 1; Belongs to the cyclin family. (283 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
E2F5E2F transcription factor 5. (345 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
TGIF2LXHomeobox protein TGIF2LX; May have a transcription role in testis; Belongs to the TALE/TGIF homeobox family. (241 aa)
USP9YUSP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
CCNT2CCNT2 isoform 4; Belongs to the cyclin family. (730 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
TFDP3Transcription factor. (405 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PCSK4PCSK4 isoform 5; Belongs to the peptidase S8 family. (708 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CK820_G0025516YBX1 isoform 1. (320 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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