37 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPTRP00000068134	annotation not available (255 aa)
	TRIM33	Tripartite motif containing 33. (1127 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	UBE2D1	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	RNF111	RNF111 isoform 5. (1003 aa)
	TGIF1	Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activitie [...] (401 aa)
	SMAD7	Mothers against decapentaplegic homolog. (491 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)
	NCOR2	Nuclear receptor corepressor 2. (2514 aa)
	SMURF2	E3 ubiquitin-protein ligase. (744 aa)
	ENSPTRP00000081714	annotation not available (310 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	NCOR1	Nuclear receptor corepressor 1. (2442 aa)
	ENSPTRP00000071568	annotation not available (98 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	USP9X	Ubiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
	RPS27A	RPS27A isoform 1. (156 aa)
	TGIF2	Homeobox protein TGIF2. (237 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	TGIF2LX	Homeobox protein TGIF2LX; May have a transcription role in testis; Belongs to the TALE/TGIF homeobox family. (241 aa)
	USP9Y	USP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
	WWTR1	WW domain containing transcription regulator 1. (400 aa)
	UBC	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	KXD1	UBA52 isoform 10. (231 aa)
	ENSPTRP00000060412	annotation not available (156 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	NEDD4L	NEDD4L isoform 6. (1254 aa)
	ENSPTRP00000063212	annotation not available (75 aa)
	SNW1	SNW domain containing 1. (571 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
	LOC748850	HDAC2 isoform 9. (445 aa)
	ENSPTRP00000067263	Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
	SKI	V-ski sarcoma viral oncogene homolog (Avian). (736 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1B4	ENSPTRP00000081714	ENSPTRP00000066466	ENSPTRP00000081714	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	annotation not available	0.897
ATP1B4	MAPK1	ENSPTRP00000066466	ENSPTRP00000024313	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.900
ATP1B4	MAPK3	ENSPTRP00000066466	ENSPTRP00000053615	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.900
ATP1B4	SMAD7	ENSPTRP00000066466	ENSPTRP00000017016	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Mothers against decapentaplegic homolog.	0.630
ATP1B4	SNW1	ENSPTRP00000066466	ENSPTRP00000064690	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	SNW domain containing 1.	0.897
ENSPTRP00000060412	ENSPTRP00000067263	ENSPTRP00000060412	ENSPTRP00000067263	annotation not available	Ubiquitin-large subunit ribosomal protein L40e.	0.961
ENSPTRP00000060412	ENSPTRP00000071568	ENSPTRP00000060412	ENSPTRP00000071568	annotation not available	annotation not available	0.920
ENSPTRP00000060412	KXD1	ENSPTRP00000060412	ENSPTRP00000060271	annotation not available	UBA52 isoform 10.	0.996
ENSPTRP00000060412	MAPK1	ENSPTRP00000060412	ENSPTRP00000024313	annotation not available	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.429
ENSPTRP00000060412	NCOR1	ENSPTRP00000060412	ENSPTRP00000075557	annotation not available	Nuclear receptor corepressor 1.	0.469
ENSPTRP00000060412	NCOR2	ENSPTRP00000060412	ENSPTRP00000088620	annotation not available	Nuclear receptor corepressor 2.	0.469
ENSPTRP00000060412	NEDD4L	ENSPTRP00000060412	ENSPTRP00000062932	annotation not available	NEDD4L isoform 6.	0.905
ENSPTRP00000060412	PARP1	ENSPTRP00000060412	ENSPTRP00000003457	annotation not available	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.527
ENSPTRP00000060412	RNF111	ENSPTRP00000060412	ENSPTRP00000012176	annotation not available	RNF111 isoform 5.	0.732
ENSPTRP00000060412	RPS27A	ENSPTRP00000060412	ENSPTRP00000020489	annotation not available	RPS27A isoform 1.	0.952
ENSPTRP00000060412	SKI	ENSPTRP00000060412	ENSPTRP00000000080	annotation not available	V-ski sarcoma viral oncogene homolog (Avian).	0.498
ENSPTRP00000060412	SKIL	ENSPTRP00000060412	ENSPTRP00000070313	annotation not available	SKI like proto-oncogene.	0.481
ENSPTRP00000060412	SMAD2	ENSPTRP00000060412	ENSPTRP00000062376	annotation not available	Mothers against decapentaplegic homolog.	0.430
ENSPTRP00000060412	SMAD3	ENSPTRP00000060412	ENSPTRP00000090625	annotation not available	Mothers against decapentaplegic homolog.	0.419
ENSPTRP00000060412	SMAD4	ENSPTRP00000060412	ENSPTRP00000017047	annotation not available	Mothers against decapentaplegic homolog.	0.501