36 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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Your Input:
	KLRD1	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
	KLRC1	NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (233 aa)
	LAT	Linker for activation of T cells. (268 aa)
	KLRC3	NKG2-E type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (261 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	SPNS3	Sphingolipid transporter 3 (putative). (512 aa)
	BTK	BTK isoform 2. (693 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	LCP2	Lymphocyte cytosolic protein 2. (533 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	GRAP2	GRB2 related adaptor protein 2. (330 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
	KLRK1	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (216 aa)
	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
	LCK	Tyrosine-protein kinase. (539 aa)
	PATR-E	Patr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
	VAV3	VAV3 isoform 2. (927 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	RAC1-2	Rac family small GTPase 1. (212 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	SPNS1	Sphingolipid transporter 1 (putative). (476 aa)
	ENSPTRP00000072507	annotation not available (659 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
	ERAS	ES cell expressed Ras. (233 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	KLRC1	ENSPTRP00000011997	ENSPTRP00000059579	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.453
B2M	KLRD1	ENSPTRP00000011997	ENSPTRP00000057110	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.660
B2M	PATR-E	ENSPTRP00000011997	ENSPTRP00000093472	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Patr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.	0.988
B2M	TYROBP	ENSPTRP00000011997	ENSPTRP00000018632	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.523
BTK	FYN	ENSPTRP00000038032	ENSPTRP00000077482	BTK isoform 2.	Tyrosine-protein kinase.	0.599
BTK	GRAP2	ENSPTRP00000038032	ENSPTRP00000024817	BTK isoform 2.	GRB2 related adaptor protein 2.	0.757
BTK	GRB2	ENSPTRP00000038032	ENSPTRP00000016382	BTK isoform 2.	Growth factor receptor-bound protein 2.	0.823
BTK	HRAS	ENSPTRP00000038032	ENSPTRP00000005495	BTK isoform 2.	V-Ha-ras Harvey rat sarcoma viral oncogene homolog.	0.434
BTK	LAT	ENSPTRP00000038032	ENSPTRP00000056922	BTK isoform 2.	Linker for activation of T cells.	0.510
BTK	LCK	ENSPTRP00000038032	ENSPTRP00000000842	BTK isoform 2.	Tyrosine-protein kinase.	0.517
BTK	LCP2	ENSPTRP00000038032	ENSPTRP00000029923	BTK isoform 2.	Lymphocyte cytosolic protein 2.	0.985
BTK	PIK3CA	ENSPTRP00000038032	ENSPTRP00000084763	BTK isoform 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.513
BTK	PIK3CB	ENSPTRP00000038032	ENSPTRP00000026618	BTK isoform 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.947
BTK	PIK3R1	ENSPTRP00000038032	ENSPTRP00000076964	BTK isoform 2.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.949
BTK	PIK3R2	ENSPTRP00000038032	ENSPTRP00000018245	BTK isoform 2.	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta).	0.938
BTK	PLCG1	ENSPTRP00000038032	ENSPTRP00000023178	BTK isoform 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.960
BTK	PLCG2	ENSPTRP00000038032	ENSPTRP00000076517	BTK isoform 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.984
BTK	SHC1	ENSPTRP00000038032	ENSPTRP00000051735	BTK isoform 2.	SHC (Src homology 2 domain containing) transforming protein 1.	0.562
BTK	SOS1	ENSPTRP00000038032	ENSPTRP00000052023	BTK isoform 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.434
BTK	SYK	ENSPTRP00000038032	ENSPTRP00000074883	BTK isoform 2.	Tyrosine-protein kinase.	0.984