STRINGSTRING
MYH9 MYH9 ENSPTRP00000079105 ENSPTRP00000079105 LIMK1-2 LIMK1-2 ACTG1 ACTG1 ENSPTRP00000080740 ENSPTRP00000080740 ENSPTRP00000077428 ENSPTRP00000077428 ENSPTRP00000076988 ENSPTRP00000076988 SRC SRC ARPC3 ARPC3 CLTCL1 CLTCL1 EPHB3 EPHB3 FYN FYN FMN2 FMN2 ENSPTRP00000072166 ENSPTRP00000072166 LOC739666 LOC739666 ENSPTRP00000070878 ENSPTRP00000070878 ENSPTRP00000070693 ENSPTRP00000070693 MYH10 MYH10 ENSPTRP00000069052 ENSPTRP00000069052 RAC1 RAC1 AP2A1 AP2A1 ENSPTRP00000066583 ENSPTRP00000066583 ENSPTRP00000066220 ENSPTRP00000066220 LOC736439 LOC736439 MYH14 MYH14 ENSPTRP00000064849 ENSPTRP00000064849 ENSPTRP00000064617 ENSPTRP00000064617 ACTR3C ACTR3C MYL12A MYL12A MYH11 MYH11 SDCBP SDCBP FMN1 FMN1 ROCK2 ROCK2 PAK3 PAK3 ARHGEF7 ARHGEF7 ACTL9 ACTL9 GIT1 GIT1 ACTB ACTB EPHB1 EPHB1 CK820_G0015929 CK820_G0015929 EPHB2 EPHB2 PSEN2 PSEN2 LIMK2 LIMK2 EFNA2 EFNA2 ELSPBP1 ELSPBP1 LYN LYN LOC744297 LOC744297 APH1A APH1A AP2B1 AP2B1 GRIN1 GRIN1 SDCBP2 SDCBP2 ACTRT1 ACTRT1 ARPC5L ARPC5L ACTL7A ACTL7A ACTL7B ACTL7B CLTA CLTA SDC2 SDC2 CK820_G0053598 CK820_G0053598 ACTR3B ACTR3B EPHA1 EPHA1 EPHB6 EPHB6 WASL WASL EPHB4 EPHB4 ARPC1B ARPC1B ARPC1A ARPC1A EPHA7 EPHA7 CLTB CLTB ENSPTRP00000081537 ENSPTRP00000081537 ENSPTRP00000081694 ENSPTRP00000081694 ENSPTRP00000081707 ENSPTRP00000081707 ITSN1 ITSN1 EFNA4 EFNA4 EPHA10 EPHA10 EPHA8 EPHA8 ACTL8 ACTL8 EPHA2 EPHA2 ACTRT2 ACTRT2 CK820_G0012542 CK820_G0012542 PTK2 PTK2 FNDC3A FNDC3A VAV2 VAV2 EPHB4-2 EPHB4-2 DNM1 DNM1 RAC1-2 RAC1-2 ARPC4 ARPC4 ROCK1 ROCK1 ENSPTRP00000084862 ENSPTRP00000084862 EFNA5 EFNA5 RASA1 RASA1 ARHGEF28 ARHGEF28 EPHA5 EPHA5 PAK2 PAK2 EPHA6 EPHA6 EPHA3 EPHA3 RHOA RHOA TIAM1 TIAM1 MMP9 MMP9 MYL9 MYL9 DSTN DSTN NGEF NGEF NCK2 NCK2 PSENEN PSENEN MYL12B MYL12B ENSPTRP00000016618 ENSPTRP00000016618 APH1B APH1B FNDC3B FNDC3B ADAM10 ADAM10 PSEN1 PSEN1 CFL2 CFL2 EFNB2 EFNB2 GRIN2B GRIN2B PAK1 PAK1 AP2A2 AP2A2 HRAS HRAS CK820_G0023253 CK820_G0023253 ARPC5 ARPC5 EFNA1 EFNA1 EFNA3 EFNA3 ENSPTRP00000085141 ENSPTRP00000085141 KALRN KALRN ENSPTRP00000085830 ENSPTRP00000085830 EPHA4 EPHA4 ENSPTRP00000086563 ENSPTRP00000086563 DNM1-2 DNM1-2 CFL1 CFL1 MMP2 MMP2 EFNB3 EFNB3 AP2S1 AP2S1 MYL6 MYL6 ENSPTRP00000089475 ENSPTRP00000089475 ENSPTRP00000089530 ENSPTRP00000089530 ARPC2 ARPC2 EFNB1 EFNB1 VAV3 VAV3 EPHA1-2 EPHA1-2 YES1 YES1 ENSPTRP00000090995 ENSPTRP00000090995 ENSPTRP00000091405 ENSPTRP00000091405 ENSPTRP00000091771 ENSPTRP00000091771 ACTR2 ACTR2 ITSN1-2 ITSN1-2 LIMK1 LIMK1 LOC468314 LOC468314 ENSPTRP00000093517 ENSPTRP00000093517 NCSTN NCSTN CLTC CLTC CDC42 CDC42 ENSPTRP00000077947 ENSPTRP00000077947 AP2M1 AP2M1 CK820_G0023066 CK820_G0023066 ENSPTRP00000078387 ENSPTRP00000078387 ENSPTRP00000078893 ENSPTRP00000078893
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ENSPTRP00000079105annotation not available (149 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
ACTG1ACTG1 isoform 13. (375 aa)
ENSPTRP00000080740annotation not available (150 aa)
ENSPTRP00000077428annotation not available (202 aa)
ENSPTRP00000076988annotation not available (871 aa)
SRCTyrosine-protein kinase. (542 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
CLTCL1CLTCL1 isoform 5. (1510 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
FYNTyrosine-protein kinase. (537 aa)
FMN2FMN2 isoform 6. (198 aa)
ENSPTRP00000072166annotation not available (318 aa)
LOC739666Syntenin-1-like. (289 aa)
ENSPTRP00000070878annotation not available (324 aa)
ENSPTRP00000070693annotation not available (228 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ENSPTRP00000069052annotation not available (151 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
ENSPTRP00000066583annotation not available (181 aa)
ENSPTRP00000066220annotation not available (211 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ENSPTRP00000064849annotation not available (150 aa)
ENSPTRP00000064617annotation not available (92 aa)
ACTR3CActin-related protein 3C isoform X1. (239 aa)
MYL12AMyosin light chain 12A. (177 aa)
MYH11MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
SDCBPSyndecan binding protein. (324 aa)
FMN1FMN1 isoform 1. (1425 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
ACTL9ACTL9 isoform 1; Belongs to the actin family. (416 aa)
GIT1G protein-coupled receptor kinase interacting ArfGAP 1. (770 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
EPHB1EPH receptor B1. (984 aa)
CK820_G0015929ARPC3 isoform 3. (178 aa)
EPHB2EPH receptor B2. (1055 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
LIMK2LIMK2 isoform 6. (670 aa)
EFNA2EFNA2 isoform 1; Belongs to the ephrin family. (190 aa)
ELSPBP1ELSPBP1 isoform 6. (219 aa)
LYNTyrosine-protein kinase. (512 aa)
LOC744297POTE ankyrin domain family member G-like. (956 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
AP2B1AP complex subunit beta. (951 aa)
GRIN1Glutamate receptor, ionotropic, N-methyl D-aspartate 1. (845 aa)
SDCBP2Syntenin-1. (292 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (376 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ACTL7AActin-like protein 7A; Belongs to the actin family. (435 aa)
ACTL7BActin-like protein 7B; Belongs to the actin family. (415 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
CK820_G0053598POTEJ isoform 1; Belongs to the actin family. (1078 aa)
ACTR3BARP3 actin-related protein 3 homolog B; Belongs to the actin family. (418 aa)
EPHA1EPH receptor A1. (976 aa)
EPHB6Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1020 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
EPHB4EPH receptor B4. (987 aa)
ARPC1BActin related protein 2/3 complex, subunit 1A/1B. (372 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
EPHA7EPHA7 isoform 2. (998 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
ENSPTRP00000081537annotation not available (449 aa)
ENSPTRP00000081694annotation not available (182 aa)
ENSPTRP00000081707annotation not available (149 aa)
ITSN1ITSN1 isoform 4. (1721 aa)
EFNA4EFNA4 isoform 1; Belongs to the ephrin family. (201 aa)
EPHA10EPH receptor A10. (1014 aa)
EPHA8EPHA8 isoform 1. (997 aa)
ACTL8ACTL8 isoform 1; Belongs to the actin family. (366 aa)
EPHA2EPH receptor A2. (976 aa)
ACTRT2ACTRT2 isoform 1; Belongs to the actin family. (377 aa)
CK820_G0012542ACTR3 isoform 5. (34 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
EPHB4-2EPH receptor B4. (987 aa)
DNM1DNM1 isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (867 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X4. (173 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ENSPTRP00000084862annotation not available (154 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
ARHGEF28ARHGEF28 isoform 4. (1731 aa)
EPHA5EPH receptor A5. (1038 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
EPHA6EPH receptor A6. (1130 aa)
EPHA3EPH receptor A3. (983 aa)
RHOARas homolog family member A. (193 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
MYL9Myosin, light chain 9, regulatory. (172 aa)
DSTNDestrin (Actin depolymerizing factor); Belongs to the actin-binding proteins ADF family. (165 aa)
NGEFNeuronal guanine nucleotide exchange factor. (710 aa)
NCK2Cytoplasmic protein. (380 aa)
PSENENT0105581 isoform 1. (101 aa)
MYL12BMyosin light chain 12B. (172 aa)
ENSPTRP00000016618Actin beta like 2. (375 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
AP2A2AP2A2 isoform 4. (380 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CK820_G0023253FMN2 isoform 2. (1196 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
EFNA3Ephrin-A3 isoform X1. (238 aa)
ENSPTRP00000085141annotation not available (333 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
ENSPTRP00000085830annotation not available (168 aa)
EPHA4EPH receptor A4. (986 aa)
ENSPTRP00000086563annotation not available (245 aa)
DNM1-2Dynamin 1. (867 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
MYL6MYL6 isoform 8. (233 aa)
ENSPTRP00000089475annotation not available (268 aa)
ENSPTRP00000089530annotation not available (141 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
VAV3VAV3 isoform 2. (927 aa)
EPHA1-2EPH receptor A1. (976 aa)
YES1Tyrosine-protein kinase. (558 aa)
ENSPTRP00000090995annotation not available (206 aa)
ENSPTRP00000091405annotation not available (334 aa)
ENSPTRP00000091771annotation not available (149 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ITSN1-2ITSN1 isoform 7. (1716 aa)
LIMK1LIM domain kinase 1. (677 aa)
LOC468314MYL6 isoform 18. (116 aa)
ENSPTRP00000093517annotation not available (149 aa)
NCSTNNCSTN isoform 1. (721 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
ENSPTRP00000077947annotation not available (48 aa)
AP2M1AP2M1 isoform 3; Belongs to the adaptor complexes medium subunit family. (459 aa)
CK820_G0023066ACTA1 isoform 2. (150 aa)
ENSPTRP00000078387annotation not available (202 aa)
ENSPTRP00000078893annotation not available (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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