STRINGSTRING
CNTN1 CNTN1 NOTCH2 NOTCH2 JAG2 JAG2 MDK MDK NEURL1B NEURL1B NCSTN NCSTN MIB1 MIB1 UBC UBC PSEN2 PSEN2 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 MIB2 MIB2 DLL4 DLL4 PSEN1 PSEN1 PSENEN PSENEN APH1B APH1B ADAM10 ADAM10 RPS27A RPS27A JAG1 JAG1 DLL1 DLL1 APH1A APH1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTN1CNTN1 isoform 1. (1028 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (558 aa)
NCSTNNCSTN isoform 1. (721 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
MIB2Mindbomb homolog 2. (991 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PSENENT0105581 isoform 1. (101 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
RPS27ARPS27A isoform 1. (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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