38 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	FGG	Fibrinogen gamma chain. (453 aa)
	CRK	V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
	AKT1	AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ENSPTRP00000076429	annotation not available (110 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	RASGRP1	RASGRP1 isoform 4. (848 aa)
	TLN1	TLN1 isoform 1. (2558 aa)
	RAP1B	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
	ENSPTRP00000068916	annotation not available (99 aa)
	ITGB3	Integrin beta-3 isoform X2. (837 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (662 aa)
	RAPGEF4	RAPGEF4 isoform 2. (1011 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (730 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1302 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	FN1	FN1 isoform 1. (2477 aa)
	FGA	Fibrinogen alpha chain. (866 aa)
	FGB	Fibrinogen beta chain. (491 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	ITGA2B	ITGA2B isoform 3; Belongs to the integrin alpha chain family. (1032 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	TLN2	TLN2 isoform 1. (2544 aa)
	EFS	Embryonal Fyn-associated substrate. (560 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	VWF	Von Willebrand factor. (2813 aa)
	RASGRP2	RAS guanyl releasing protein 2. (609 aa)
	APBB1IP	APBB1IP isoform 1. (665 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1198 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1204 aa)
	CASS4	CASS4 isoform 2. (812 aa)
	PDPK1	3-phosphoinositide dependent protein kinase-1. (542 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BCAR1	ENSPTRP00000082849	ENSPTRP00000079661	AKT1 isoform 3; Belongs to the protein kinase superfamily.	BCAR1 scaffold protein, Cas family member.	0.683
AKT1	CRK	ENSPTRP00000082849	ENSPTRP00000083173	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.653
AKT1	CSK	ENSPTRP00000082849	ENSPTRP00000012464	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.534
AKT1	ENSPTRP00000068916	ENSPTRP00000082849	ENSPTRP00000068916	AKT1 isoform 3; Belongs to the protein kinase superfamily.	annotation not available	0.404
AKT1	ENSPTRP00000076429	ENSPTRP00000082849	ENSPTRP00000076429	AKT1 isoform 3; Belongs to the protein kinase superfamily.	annotation not available	0.541
AKT1	GRB2	ENSPTRP00000082849	ENSPTRP00000016382	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Growth factor receptor-bound protein 2.	0.777
AKT1	ITGB3	ENSPTRP00000082849	ENSPTRP00000068323	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Integrin beta-3 isoform X2.	0.539
AKT1	NEDD9	ENSPTRP00000082849	ENSPTRP00000093102	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Neural precursor cell expressed, developmentally down-regulated 9.	0.523
AKT1	PDPK1	ENSPTRP00000082849	ENSPTRP00000090334	AKT1 isoform 3; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase-1.	0.974
AKT1	PTK2	ENSPTRP00000082849	ENSPTRP00000083824	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.739
AKT1	PTPN1	ENSPTRP00000082849	ENSPTRP00000043532	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Tyrosine-protein phosphatase non-receptor type.	0.615
AKT1	RAP1A	ENSPTRP00000082849	ENSPTRP00000084644	AKT1 isoform 3; Belongs to the protein kinase superfamily.	RAP1A, member of RAS oncogene family.	0.595
AKT1	RAP1B	ENSPTRP00000082849	ENSPTRP00000070769	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.	0.404
AKT1	RAPGEF3	ENSPTRP00000082849	ENSPTRP00000008316	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Rap guanine nucleotide exchange factor 3.	0.443
AKT1	RAPGEF4	ENSPTRP00000082849	ENSPTRP00000062019	AKT1 isoform 3; Belongs to the protein kinase superfamily.	RAPGEF4 isoform 2.	0.428
AKT1	RAPH1	ENSPTRP00000082849	ENSPTRP00000048840	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1.	0.534
AKT1	SHC1	ENSPTRP00000082849	ENSPTRP00000051735	AKT1 isoform 3; Belongs to the protein kinase superfamily.	SHC (Src homology 2 domain containing) transforming protein 1.	0.667
AKT1	SOS1	ENSPTRP00000082849	ENSPTRP00000052023	AKT1 isoform 3; Belongs to the protein kinase superfamily.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.646
AKT1	SRC	ENSPTRP00000082849	ENSPTRP00000076797	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.927
AKT1	SYK	ENSPTRP00000082849	ENSPTRP00000074883	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.542