91 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD72	CD72 isoform 2. (359 aa)
	PLXNA3	PLXNA3 isoform 1. (1871 aa)
	SEMA4D	SEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
	LIMK2	LIMK2 isoform 6. (670 aa)
	DPYSL5	DPYSL5 isoform 1. (565 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	PKHD1L1	PKHD1L1 isoform 1. (4264 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
	PLXNA4	PLXNA4 isoform 1. (1894 aa)
	PAK3	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
	ENSPTRP00000062610	annotation not available (279 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	MYH11	MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
	ENSPTRP00000064617	annotation not available (92 aa)
	MYH14	Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
	SEMA3E	SEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
	ENSPTRP00000066220	annotation not available (211 aa)
	RHOB	Ras homolog gene family, member B. (286 aa)
	SEMA6A	SEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
	SEMA4A	SEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
	ENSPTRP00000069052	annotation not available (151 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
	CRMP1	Collapsin response mediator protein 1. (686 aa)
	DPYSL2	Dihydropyrimidinase-like 2. (677 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
	TLN1	TLN1 isoform 1. (2558 aa)
	RHOC	Rho-related GTP-binding protein RhoC isoform X1. (196 aa)
	DPYSL3	Dihydropyrimidinase-like 3. (684 aa)
	ARHGAP35	Glucocorticoid receptor DNA binding factor 1. (1519 aa)
	PLXNC1	PLXNC1 isoform 1. (1568 aa)
	LOC101057895	Heat shock protein HSP 90-alpha pseudogene. (670 aa)
	CK820_G0024813	HSP90AA1 isoform 6. (367 aa)
	PLXNB2	PLXNB2 isoform 1. (1838 aa)
	ENSPTRP00000077428	annotation not available (202 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	LOC461365	Heat shock protein HSP 90-beta pseudogene. (584 aa)
	LOC468314	MYL6 isoform 18. (116 aa)
	LIMK1	LIM domain kinase 1. (677 aa)
	PLXNB3	PLXNB3 isoform 1. (1932 aa)
	ENSPTRP00000091771	annotation not available (149 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
	ENSPTRP00000089530	annotation not available (141 aa)
	MYL6	MYL6 isoform 8. (233 aa)
	PLXNA1	PLXNA1 isoform 1. (1915 aa)
	LOC107968084	Heat shock protein HSP 90-beta-like. (361 aa)
	CFL1	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
	ENSPTRP00000086478	annotation not available (333 aa)
	SEMA3B	SEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
	ENSPTRP00000084862	annotation not available (154 aa)
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
	RAC1-2	Rac family small GTPase 1. (212 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	SEMA6D	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1054 aa)
	CDK5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
	LIMK1-2	LIM domain kinase 1. (677 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
	SEMA6C	SEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1306 aa)
	PLXNA2	PLXNA2 isoform 1. (1909 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	DPYSL4	Dihydropyrimidinase-like 4. (572 aa)
	PAK1	Non-specific serine/threonine protein kinase. (553 aa)
	RND1	RND1 isoform 1. (163 aa)
	CFL2	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
	TLN2	TLN2 isoform 1. (2544 aa)
	SEMA7A	SEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
	SEMA4B	SEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
	MYL12B	Myosin light chain 12B. (172 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
	SEMA6B	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
	RRAS	Related RAS viral (R-ras) oncogene homolog. (218 aa)
	DSTN	Destrin (Actin depolymerizing factor); Belongs to the actin-binding proteins ADF family. (165 aa)
	MYL9	Myosin, light chain 9, regulatory. (172 aa)
	PLXNB1	PLXNB1 isoform 1. (2135 aa)
	RHOA	Ras homolog family member A. (193 aa)
	SEMA3G	SEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
	PLXND1	PLXND1 isoform 1. (1925 aa)
	PAK2	Non-specific serine/threonine protein kinase. (476 aa)
	SEMA5A	SEMA5A isoform 1. (1074 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	HSP90AB1	HSP90AB1 isoform 1. (688 aa)
	PKHD1	PKHD1 isoform 1. (4074 aa)
	SEMA3A	SEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	ARHGEF11	ENSPTRP00000075057	ENSPTRP00000091210	Glucocorticoid receptor DNA binding factor 1.	Rho guanine nucleotide exchange factor (GEF) 11.	0.436
ARHGAP35	ARHGEF12	ENSPTRP00000075057	ENSPTRP00000058269	Glucocorticoid receptor DNA binding factor 1.	Rho guanine nucleotide exchange factor (GEF) 12.	0.420
ARHGAP35	CFL1	ENSPTRP00000075057	ENSPTRP00000087369	Glucocorticoid receptor DNA binding factor 1.	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.	0.548
ARHGAP35	CFL2	ENSPTRP00000075057	ENSPTRP00000010616	Glucocorticoid receptor DNA binding factor 1.	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.554
ARHGAP35	ENSPTRP00000091771	ENSPTRP00000075057	ENSPTRP00000091771	Glucocorticoid receptor DNA binding factor 1.	annotation not available	0.467
ARHGAP35	ERBB2	ENSPTRP00000075057	ENSPTRP00000069840	Glucocorticoid receptor DNA binding factor 1.	Receptor protein-tyrosine kinase.	0.432
ARHGAP35	FYN	ENSPTRP00000075057	ENSPTRP00000077482	Glucocorticoid receptor DNA binding factor 1.	Tyrosine-protein kinase.	0.620
ARHGAP35	MET	ENSPTRP00000075057	ENSPTRP00000083162	Glucocorticoid receptor DNA binding factor 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.629
ARHGAP35	PLXNB1	ENSPTRP00000075057	ENSPTRP00000025675	Glucocorticoid receptor DNA binding factor 1.	PLXNB1 isoform 1.	0.497
ARHGAP35	PLXNB2	ENSPTRP00000075057	ENSPTRP00000077349	Glucocorticoid receptor DNA binding factor 1.	PLXNB2 isoform 1.	0.477
ARHGAP35	PLXNB3	ENSPTRP00000075057	ENSPTRP00000092121	Glucocorticoid receptor DNA binding factor 1.	PLXNB3 isoform 1.	0.412
ARHGAP35	RAC1	ENSPTRP00000075057	ENSPTRP00000068561	Glucocorticoid receptor DNA binding factor 1.	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.465
ARHGAP35	RAC1-2	ENSPTRP00000075057	ENSPTRP00000084384	Glucocorticoid receptor DNA binding factor 1.	Rac family small GTPase 1.	0.465
ARHGAP35	RHOA	ENSPTRP00000075057	ENSPTRP00000025759	Glucocorticoid receptor DNA binding factor 1.	Ras homolog family member A.	0.995
ARHGAP35	RHOB	ENSPTRP00000075057	ENSPTRP00000066459	Glucocorticoid receptor DNA binding factor 1.	Ras homolog gene family, member B.	0.843
ARHGAP35	RHOC	ENSPTRP00000075057	ENSPTRP00000071746	Glucocorticoid receptor DNA binding factor 1.	Rho-related GTP-binding protein RhoC isoform X1.	0.901
ARHGAP35	RND1	ENSPTRP00000075057	ENSPTRP00000008358	Glucocorticoid receptor DNA binding factor 1.	RND1 isoform 1.	0.868
ARHGAP35	ROCK1	ENSPTRP00000075057	ENSPTRP00000084841	Glucocorticoid receptor DNA binding factor 1.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...]	0.601
ARHGAP35	SEMA4D	ENSPTRP00000075057	ENSPTRP00000049238	Glucocorticoid receptor DNA binding factor 1.	SEMA4D isoform 13; Belongs to the semaphorin family.	0.547
ARHGEF11	ARHGAP35	ENSPTRP00000091210	ENSPTRP00000075057	Rho guanine nucleotide exchange factor (GEF) 11.	Glucocorticoid receptor DNA binding factor 1.	0.436