node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | FSHB | ENSPTRP00000088679 | ENSPTRP00000006017 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.999 |
CGA | FSHR | ENSPTRP00000088679 | ENSPTRP00000020457 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.963 |
CGA | GPHA2 | ENSPTRP00000088679 | ENSPTRP00000006641 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Glycoprotein-alpha 2. | 0.837 |
CGA | GPHB5 | ENSPTRP00000088679 | ENSPTRP00000078124 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Glycoprotein hormone subunit beta 5. | 0.804 |
CGA | LHB | ENSPTRP00000088679 | ENSPTRP00000079684 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.950 |
CGA | LHCGR | ENSPTRP00000088679 | ENSPTRP00000020451 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.810 |
CGA | TSHB | ENSPTRP00000088679 | ENSPTRP00000001962 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyroid stimulating hormone subunit beta. | 0.996 |
CGA | TSHR | ENSPTRP00000088679 | ENSPTRP00000091100 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.919 |
ENSPTRP00000002048 | ENSPTRP00000052437 | ENSPTRP00000002048 | ENSPTRP00000052437 | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | Gonadotropin releasing hormone 2, pseudogene. | 0.599 |
ENSPTRP00000002048 | FSHB | ENSPTRP00000002048 | ENSPTRP00000006017 | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.533 |
ENSPTRP00000002048 | GNRH1 | ENSPTRP00000002048 | ENSPTRP00000034399 | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.970 |
ENSPTRP00000002048 | GNRHR | ENSPTRP00000002048 | ENSPTRP00000027689 | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. | 0.900 |
ENSPTRP00000052437 | ENSPTRP00000002048 | ENSPTRP00000052437 | ENSPTRP00000002048 | Gonadotropin releasing hormone 2, pseudogene. | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | 0.599 |
ENSPTRP00000052437 | FSHB | ENSPTRP00000052437 | ENSPTRP00000006017 | Gonadotropin releasing hormone 2, pseudogene. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.497 |
ENSPTRP00000052437 | GNRH1 | ENSPTRP00000052437 | ENSPTRP00000034399 | Gonadotropin releasing hormone 2, pseudogene. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.824 |
ENSPTRP00000052437 | GNRHR | ENSPTRP00000052437 | ENSPTRP00000027689 | Gonadotropin releasing hormone 2, pseudogene. | Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. | 0.901 |
FSHB | CGA | ENSPTRP00000006017 | ENSPTRP00000088679 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.999 |
FSHB | ENSPTRP00000002048 | ENSPTRP00000006017 | ENSPTRP00000002048 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. | 0.533 |
FSHB | ENSPTRP00000052437 | ENSPTRP00000006017 | ENSPTRP00000052437 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Gonadotropin releasing hormone 2, pseudogene. | 0.497 |
FSHB | FSHR | ENSPTRP00000006017 | ENSPTRP00000020457 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.999 |