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CENPJ CENPJ HAUS2 HAUS2 CCP110 CCP110 YWHAE YWHAE TUBG1 TUBG1 CEP131 CEP131 CEP76 CEP76 HAUS1 HAUS1 PRKACA PRKACA HAUS8 HAUS8 HAUS5 HAUS5 DCTN1 DCTN1 TUBA4A TUBA4A CEP63 CEP63 CEP70 CEP70 CEP135 CEP135 PLK4 PLK4 CEP72 CEP72 TCP10L2 TCP10L2 YWHAG YWHAG PCM1 PCM1 HAUS6 HAUS6 SSNA1 SSNA1 OFD1 OFD1 CETN2 CETN2 PCNT PCNT TSGA10 TSGA10 AKAP9 AKAP9 CKAP5 CKAP5 CNTRL CNTRL SFI1 SFI1 CDK1 CDK1 MAPRE1 MAPRE1 LOC735377 LOC735377 CDK5RAP2 CDK5RAP2 TCP10L TCP10L ENSPTRP00000059866 ENSPTRP00000059866 PRKAR2B PRKAR2B CROCC2 CROCC2 FOPNL FOPNL CEP78 CEP78 CEP192 CEP192 AKAP9-2 AKAP9-2 LOC469195 LOC469195 ODF2 ODF2 CSNK1D CSNK1D DYNC1I2 DYNC1I2 HAUS7 HAUS7 CROCC CROCC HSP90AA1 HSP90AA1 ENSPTRP00000071420 ENSPTRP00000071420 CLASP1 CLASP1 DCTN3 DCTN3 ENSPTRP00000073474 ENSPTRP00000073474 NDE1 NDE1 ENSPTRP00000074041 ENSPTRP00000074041 ENSPTRP00000075494 ENSPTRP00000075494 PAFAH1B1 PAFAH1B1 DYNC1H1 DYNC1H1 ODF2L ODF2L LOC745637 LOC745637 CETN2-2 CETN2-2 ENSPTRP00000081745 ENSPTRP00000081745 CEP152 CEP152 ENSPTRP00000082446 ENSPTRP00000082446 CEP41 CEP41 PPP2R1A PPP2R1A DCTN2 DCTN2 NINL NINL CCR6 CCR6 LOC459638 LOC459638 CK820_G0019512 CK820_G0019512 CEP250 CEP250 ENSPTRP00000087593 ENSPTRP00000087593 ENSPTRP00000087686 ENSPTRP00000087686 ENSPTRP00000088633 ENSPTRP00000088633 ALMS1 ALMS1 ENSPTRP00000088766 ENSPTRP00000088766 HAUS3 HAUS3 CSNK1E CSNK1E ENSPTRP00000090501 ENSPTRP00000090501 ENSPTRP00000091433 ENSPTRP00000091433 PDE4DIP PDE4DIP ENSPTRP00000093753 ENSPTRP00000093753 PLK1 PLK1 ENSPTRP00000093880 ENSPTRP00000093880 NEK2 NEK2 TUBB TUBB SDCCAG8 SDCCAG8 ACTR1A ACTR1A CEP57 CEP57 CEP164 CEP164 TUBA1A TUBA1A CEP290 CEP290 NEDD1 NEDD1 DYNLL1 DYNLL1 HAUS4 HAUS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CENPJCentromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born [...] (1338 aa)
HAUS2HAUS augmin-like complex, subunit 2. (235 aa)
CCP110CCP110 isoform 2. (1012 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
CEP1315-azacytidine induced 1. (1083 aa)
CEP76Centrosomal protein 76kDa. (659 aa)
HAUS1HAUS augmin like complex subunit 1. (278 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
HAUS8HAUS8 isoform 1. (409 aa)
HAUS5HAUS augmin-like complex, subunit 5. (633 aa)
DCTN1T0125321 isoform 1. (1278 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
CEP63Centrosomal protein 63kDa. (703 aa)
CEP70Centrosomal protein 70kDa. (597 aa)
CEP135Centrosomal protein 135kDa. (1140 aa)
PLK4Polo-like kinase 4. (970 aa)
CEP72CEP72 isoform 3. (610 aa)
TCP10L2TCP10 isoform 2. (353 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family. (247 aa)
PCM1Pericentriolar material 1. (2024 aa)
HAUS6HAUS augmin-like complex, subunit 6. (954 aa)
SSNA1Sjogren syndrome nuclear autoantigen 1. (119 aa)
OFD1OFD1 centriole and centriolar satellite protein. (1012 aa)
CETN2Centrin 2. (176 aa)
PCNTPCNT isoform 1. (3271 aa)
TSGA10Testis specific, 10. (698 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
CKAP5Cytoskeleton associated protein 5. (2032 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
SFI1SFI1 centrin binding protein. (1241 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
MAPRE1MAPRE1 isoform 1. (268 aa)
LOC735377Dynein light chain 1, cytoplasmic-like. (89 aa)
CDK5RAP2CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of [...] (1903 aa)
TCP10LT-complex protein 10A homolog 1; May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. (169 aa)
ENSPTRP00000059866annotation not available (108 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
CROCC2CROCC2 isoform 1. (1655 aa)
FOPNLFOPNL isoform 8. (197 aa)
CEP78Centrosomal protein 78kDa. (722 aa)
CEP192Centrosomal protein 192. (2537 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
LOC469195Dynein light chain 1, cytoplasmic-like. (89 aa)
ODF2Outer dense fiber of sperm tails 2. (829 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
DYNC1I2DYNC1I2 isoform 11. (650 aa)
HAUS7HAUS7 isoform 1. (381 aa)
CROCCCROCC isoform 1. (2017 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
ENSPTRP00000071420annotation not available (392 aa)
CLASP1Cytoplasmic linker associated protein 1. (1549 aa)
DCTN3Dynactin subunit 3. (176 aa)
ENSPTRP00000073474annotation not available (1212 aa)
NDE1NudE nuclear distribution gene E homolog 1. (359 aa)
ENSPTRP00000074041annotation not available (223 aa)
ENSPTRP00000075494annotation not available (194 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
DYNC1H1Dynein, cytoplasmic 1, heavy chain 1. (4646 aa)
ODF2LODF2L isoform 1. (636 aa)
LOC745637Tubulin beta-7 chain pseudogene. (432 aa)
CETN2-2Centrin, EF-hand protein, 2. (172 aa)
ENSPTRP00000081745annotation not available (118 aa)
CEP152Centrosomal protein 152kDa. (1710 aa)
ENSPTRP00000082446annotation not available (194 aa)
CEP41Centrosomal protein 41. (373 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
DCTN2Dynactin subunit 2. (406 aa)
NINLNINL isoform 1. (1386 aa)
CCR6FGFR1 oncogene partner. (444 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
CK820_G0019512HAUS1 isoform 4. (91 aa)
CEP250CEP250 isoform 4. (2443 aa)
ENSPTRP00000087593annotation not available (91 aa)
ENSPTRP00000087686annotation not available (329 aa)
ENSPTRP00000088633annotation not available (430 aa)
ALMS1ALMS1 isoform 1. (4169 aa)
ENSPTRP00000088766annotation not available (199 aa)
HAUS3HAUS augmin-like complex, subunit 3. (603 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa)
ENSPTRP00000090501annotation not available (192 aa)
ENSPTRP00000091433T-complex protein 10A homolog isoform X1. (167 aa)
PDE4DIPPDE4DIP isoform 9. (2319 aa)
ENSPTRP00000093753Dynein light chain 1, cytoplasmic-like. (87 aa)
PLK1Serine/threonine-protein kinase PLK. (621 aa)
ENSPTRP00000093880annotation not available (101 aa)
NEK2NIMA (Never in mitosis gene a)-related kinase 2. (445 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (444 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (713 aa)
ACTR1AAlpha-centractin. (351 aa)
CEP57Centrosomal protein 57kDa. (500 aa)
CEP164Centrosomal protein 164kDa. (1459 aa)
TUBA1ADetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (451 aa)
CEP290CEP290 isoform 5. (2454 aa)
NEDD1NEDD1 gamma-tubulin ring complex targeting factor. (660 aa)
DYNLL1Dynein light chain. (89 aa)
HAUS4T0103089 isoform 1. (363 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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