STRINGSTRING
RELCH RELCH TNFRSF14 TNFRSF14 MTOR MTOR LCK LCK THEM4 THEM4 MAP3K8 MAP3K8 FNBP4 FNBP4 PPP2R5B PPP2R5B PAK1 PAK1 PPP2R1B PPP2R1B CD3E CD3E CD3D CD3D CD3G CD3G PPP2R5C PPP2R5C CD276 CD276 CSK CSK GRB2 GRB2 VAV1 VAV1 PIK3R2 PIK3R2 CD28 CD28 ICOS ICOS TRIB3 TRIB3 GRAP2 GRAP2 PRR5 PRR5 CD80 CD80 CD86 CD86 PAK2 PAK2 ENSPTRP00000029492 ENSPTRP00000029492 HLA-DQB2 HLA-DQB2 PATR-DRB5 PATR-DRB5 PATR-DRA PATR-DRA HLA-DQA2 HLA-DQA2 HLA-DQB1 HLA-DQB1 HLA-DPA1 HLA-DPA1 PPP2R5D PPP2R5D CD274 CD274 MAPKAP1 MAPKAP1 BTLA BTLA CD247 CD247 LYN LYN PPP4R1 PPP4R1 PTPN6 PTPN6 LOC104006793 LOC104006793 CD4 CD4 HLA-DQA1 HLA-DQA1 MAP3K14 MAP3K14 HLA-DPB1 HLA-DPB1 PATR-DQB1 PATR-DQB1 PTPN11 PTPN11 PAK3 PAK3 PPP2CA PPP2CA PIK3R3 PIK3R3 ENSPTRP00000064286 ENSPTRP00000064286 ENSPTRP00000065717 ENSPTRP00000065717 ENSPTRP00000066583 ENSPTRP00000066583 ENSPTRP00000067174 ENSPTRP00000067174 ENSPTRP00000067397 ENSPTRP00000067397 RAC1 RAC1 MLST8 MLST8 PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 RICTOR RICTOR SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 FYN FYN CDC42 CDC42 PGBD4 PGBD4 PPP2R5A PPP2R5A ENSPTRP00000079634 ENSPTRP00000079634 CTLA4 CTLA4 TRAC TRAC PDCD1 PDCD1 ENSPTRP00000081537 ENSPTRP00000081537 ENSPTRP00000081694 ENSPTRP00000081694 BV7-9 BV7-9 AKT1 AKT1 PPP2R1A PPP2R1A FNDC3A FNDC3A RAC1-2 RAC1-2 PIK3CA PIK3CA FNDC3B FNDC3B AKT3 AKT3 LOC100612020 LOC100612020 PPP2R5E PPP2R5E PPP2CB PPP2CB AKT2 AKT2 ENSPTRP00000093667 ENSPTRP00000093667 CK820_G0024820 CK820_G0024820 PDPK1 PDPK1 PPP4R4 PPP4R4 YES1 YES1 ICOSLG ICOSLG CK820_G0029520 CK820_G0029520 PDCD1LG2 PDCD1LG2 ENSPTRP00000092364 ENSPTRP00000092364
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LCKTyrosine-protein kinase. (539 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
FNBP4Formin binding protein 4. (1019 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
CD3ECD3E isoform 2. (207 aa)
CD3DCD3D isoform 1. (171 aa)
CD3GCD3G isoform 1. (182 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
CD276CD276 isoform 13. (534 aa)
CSKTyrosine-protein kinase. (450 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CD28CD28 isoform 3. (220 aa)
ICOSInducible T cell costimulator. (199 aa)
TRIB3TRIB3 isoform 4. (386 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
PRR5Proline-rich protein 5 isoform X2. (411 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
ENSPTRP00000029492annotation not available (223 aa)
HLA-DQB2HLA-DQB2 isoform 3. (279 aa)
PATR-DRB5HLA-DRB5 isoform 1. (282 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2. (255 aa)
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CD274CD274 isoform 2. (290 aa)
MAPKAP1Mitogen-activated protein kinase associated protein 1. (522 aa)
BTLAB and T lymphocyte associated. (289 aa)
CD247CD247 isoform 2. (163 aa)
LYNTyrosine-protein kinase. (512 aa)
PPP4R1Protein phosphatase 4, regulatory subunit 1. (950 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC104006793HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
HLA-DQA1HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
PATR-DQB1HLA-DRB1 isoform 1. (271 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
ENSPTRP00000064286annotation not available (260 aa)
ENSPTRP00000065717annotation not available (260 aa)
ENSPTRP00000066583annotation not available (181 aa)
ENSPTRP00000067174annotation not available (502 aa)
ENSPTRP00000067397annotation not available (142 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
MLST8MLST8 isoform 3. (327 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PGBD4PiggyBac transposable element derived 4. (585 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
ENSPTRP00000079634annotation not available (143 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
TRACTRAC isoform 1. (147 aa)
PDCD1Programmed cell death 1. (288 aa)
ENSPTRP00000081537annotation not available (449 aa)
ENSPTRP00000081694annotation not available (182 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC100612020Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (954 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSPTRP00000093667annotation not available (130 aa)
CK820_G0024820PPP2R5C isoform 26. (479 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
PPP4R4Protein phosphatase 4, regulatory subunit 4. (873 aa)
YES1Tyrosine-protein kinase. (558 aa)
ICOSLGICOSLG isoform 3. (590 aa)
CK820_G0029520TRAV29DV5 isoform 1. (142 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (288 aa)
ENSPTRP00000092364annotation not available (574 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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