STRINGSTRING
RAC1-2 RAC1-2 YES1 YES1 PDPK1 PDPK1 AKT2 AKT2 AKT3 AKT3 FNDC3B FNDC3B PIK3CA PIK3CA FNDC3A FNDC3A AKT1 AKT1 ENSPTRP00000081694 ENSPTRP00000081694 ENSPTRP00000081537 ENSPTRP00000081537 CDC42 CDC42 FYN FYN PIK3R1 PIK3R1 SRC SRC RICTOR RICTOR MLST8 MLST8 RAC1 RAC1 ENSPTRP00000066583 ENSPTRP00000066583 PIK3R3 PIK3R3 PAK3 PAK3 MAP3K14 MAP3K14 LYN LYN MAPKAP1 MAPKAP1 PAK2 PAK2 CD86 CD86 CD80 CD80 PRR5 PRR5 GRAP2 GRAP2 TRIB3 TRIB3 CD28 CD28 PIK3R2 PIK3R2 VAV1 VAV1 GRB2 GRB2 CD276 CD276 PAK1 PAK1 MAP3K8 MAP3K8 THEM4 THEM4 LCK LCK MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC1-2Rac family small GTPase 1. (212 aa)
YES1Tyrosine-protein kinase. (558 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ENSPTRP00000081694annotation not available (182 aa)
ENSPTRP00000081537annotation not available (449 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SRCTyrosine-protein kinase. (542 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
MLST8MLST8 isoform 3. (327 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
ENSPTRP00000066583annotation not available (181 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
LYNTyrosine-protein kinase. (512 aa)
MAPKAP1Mitogen-activated protein kinase associated protein 1. (522 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
CD86CD86 isoform 3. (329 aa)
CD80CD80 isoform 1. (288 aa)
PRR5Proline-rich protein 5 isoform X2. (411 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
TRIB3TRIB3 isoform 4. (386 aa)
CD28CD28 isoform 3. (220 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CD276CD276 isoform 13. (534 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
LCKTyrosine-protein kinase. (539 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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