STRINGSTRING
LCK LCK RAC1-2 RAC1-2 ENSPTRP00000081694 ENSPTRP00000081694 CDC42 CDC42 FYN FYN RAC1 RAC1 ENSPTRP00000066583 ENSPTRP00000066583 PAK3 PAK3 PAK2 PAK2 CD86 CD86 CD80 CD80 CD28 CD28 VAV1 VAV1 GRB2 GRB2 CD276 CD276 PAK1 PAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LCKTyrosine-protein kinase. (539 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
ENSPTRP00000081694annotation not available (182 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
FYNTyrosine-protein kinase. (537 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
ENSPTRP00000066583annotation not available (181 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
CD86CD86 isoform 3. (329 aa)
CD80CD80 isoform 1. (288 aa)
CD28CD28 isoform 3. (220 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CD276CD276 isoform 13. (534 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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