22 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK2B	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	SIRPA	Signal-regulatory protein alpha. (504 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	ENSPTRP00000067174	annotation not available (502 aa)
	SIRPG	Signal regulatory protein gamma. (387 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	ENSPTRP00000074763	annotation not available (520 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ENSPTRP00000077211	annotation not available (269 aa)
	SFTPD	Surfactant protein D. (375 aa)
	LOC458036	T0061165 isoform 1. (427 aa)
	SIRPD	LOW QUALITY PROTEIN: signal-regulatory protein delta. (198 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
	SFTPA1	Surfactant protein A1. (263 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	ENSPTRP00000092364	annotation not available (574 aa)
	FYB1	FYB1 isoform 3. (839 aa)
	SFTPA2	Surfactant protein A2. (258 aa)
	SKAP2	Src kinase associated phosphoprotein 2. (359 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	CD47	CD47 isoform 2. (323 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD47	ENSPTRP00000067174	ENSPTRP00000080534	ENSPTRP00000067174	CD47 isoform 2.	annotation not available	0.519
CD47	ENSPTRP00000074763	ENSPTRP00000080534	ENSPTRP00000074763	CD47 isoform 2.	annotation not available	0.479
CD47	ENSPTRP00000077211	ENSPTRP00000080534	ENSPTRP00000077211	CD47 isoform 2.	annotation not available	0.479
CD47	ENSPTRP00000092364	ENSPTRP00000080534	ENSPTRP00000092364	CD47 isoform 2.	annotation not available	0.479
CD47	GRB2	ENSPTRP00000080534	ENSPTRP00000016382	CD47 isoform 2.	Growth factor receptor-bound protein 2.	0.479
CD47	LOC458036	ENSPTRP00000080534	ENSPTRP00000022540	CD47 isoform 2.	T0061165 isoform 1.	0.973
CD47	PTK2	ENSPTRP00000080534	ENSPTRP00000083824	CD47 isoform 2.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.459
CD47	PTK2B	ENSPTRP00000080534	ENSPTRP00000034416	CD47 isoform 2.	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.551
CD47	PTPN11	ENSPTRP00000080534	ENSPTRP00000061336	CD47 isoform 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.519
CD47	PTPN11-2	ENSPTRP00000080534	ENSPTRP00000073224	CD47 isoform 2.	Protein tyrosine phosphatase non-receptor type 11.	0.519
CD47	SIRPA	ENSPTRP00000080534	ENSPTRP00000052461	CD47 isoform 2.	Signal-regulatory protein alpha.	0.998
CD47	SIRPD	ENSPTRP00000080534	ENSPTRP00000022536	CD47 isoform 2.	LOW QUALITY PROTEIN: signal-regulatory protein delta.	0.652
CD47	SIRPG	ENSPTRP00000080534	ENSPTRP00000068037	CD47 isoform 2.	Signal regulatory protein gamma.	0.990
CD47	SKAP2	ENSPTRP00000080534	ENSPTRP00000084633	CD47 isoform 2.	Src kinase associated phosphoprotein 2.	0.498
CD47	SRC	ENSPTRP00000080534	ENSPTRP00000076797	CD47 isoform 2.	Tyrosine-protein kinase.	0.450
CD47	TYROBP	ENSPTRP00000080534	ENSPTRP00000018632	CD47 isoform 2.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.454
ENSPTRP00000067174	CD47	ENSPTRP00000067174	ENSPTRP00000080534	annotation not available	CD47 isoform 2.	0.519
ENSPTRP00000067174	GRB2	ENSPTRP00000067174	ENSPTRP00000016382	annotation not available	Growth factor receptor-bound protein 2.	0.991
ENSPTRP00000067174	LOC458036	ENSPTRP00000067174	ENSPTRP00000022540	annotation not available	T0061165 isoform 1.	0.823
ENSPTRP00000067174	PTK2	ENSPTRP00000067174	ENSPTRP00000083824	annotation not available	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.903