STRINGSTRING
ISL1 ISL1 SPCS3 SPCS3 SPCS1 SPCS1 FAP FAP DPP10 DPP10 FFAR1 FFAR1 DPP9 DPP9 SEC11C SEC11C SEC11A SEC11A TCF7L2 TCF7L2 GATA4 GATA4 SPCS2-2 SPCS2-2 LEP LEP CDX2 CDX2 GNB1 GNB1 DPP6 DPP6 GNG13 GNG13 ENSPTRP00000063585 ENSPTRP00000063585 PAX6 PAX6 ALX3 ALX3 FFAR4 FFAR4 SPCS2 SPCS2 GRP GRP GIP GIP ISL2 ISL2 DPP8 DPP8 GNAT3 GNAT3 GCG GCG GPR119 GPR119 GNB3 GNB3 CTNNB1 CTNNB1 DPP4 DPP4 CDX4 CDX4 CDX1 CDX1 PCSK1 PCSK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL1ISL LIM homeobox 1. (349 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
FAPFibroblast activation protein, alpha; Belongs to the peptidase S9B family. (760 aa)
DPP10DPP10 isoform 3; Belongs to the peptidase S9B family. (881 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
DPP9Dipeptidyl-peptidase 9; Belongs to the peptidase S9B family. (892 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (195 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
GATA4GATA binding protein 4. (443 aa)
SPCS2-2Signal peptidase complex subunit 2. (185 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CDX2Caudal type homeobox 2. (313 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
DPP6Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Belongs to the peptidase S9B family. (803 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ENSPTRP00000063585annotation not available (187 aa)
PAX6PAX6 isoform 13. (436 aa)
ALX3ALX homeobox 3. (343 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
SPCS2Signal peptidase complex subunit 2. (257 aa)
GRPGastrin releasing peptide. (138 aa)
GIPGastric inhibitory polypeptide. (153 aa)
ISL2ISL LIM homeobox 2. (359 aa)
DPP8Dipeptidyl peptidase 8; Belongs to the peptidase S9B family. (915 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
GCGGCG isoform 1. (180 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
GNB3G protein subunit beta 3. (340 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
DPP4Dipeptidyl-peptidase 4; Belongs to the peptidase S9B family. (766 aa)
CDX4Caudal type homeobox 4. (284 aa)
CDX1CDX1 isoform 1. (265 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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