29 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PLXNB1	PLXNB1 isoform 1. (2135 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
	MYL9	Myosin, light chain 9, regulatory. (172 aa)
	RRAS	Related RAS viral (R-ras) oncogene homolog. (218 aa)
	MYL12B	Myosin light chain 12B. (172 aa)
	RND1	RND1 isoform 1. (163 aa)
	RHOC	Rho-related GTP-binding protein RhoC isoform X1. (196 aa)
	ARHGAP35	Glucocorticoid receptor DNA binding factor 1. (1519 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
	LIMK1-2	LIM domain kinase 1. (677 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	RAC1-2	Rac family small GTPase 1. (212 aa)
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
	MYL6	MYL6 isoform 8. (233 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
	LIMK1	LIM domain kinase 1. (677 aa)
	LOC468314	MYL6 isoform 18. (116 aa)
	ENSPTRP00000064617	annotation not available (92 aa)
	MYH11	MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	LIMK2	LIMK2 isoform 6. (670 aa)
	SEMA4D	SEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
	RHOA	Ras homolog family member A. (193 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
	ENSPTRP00000069052	annotation not available (151 aa)
	MYH14	Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
	RHOB	Ras homolog gene family, member B. (286 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	ARHGEF11	ENSPTRP00000075057	ENSPTRP00000091210	Glucocorticoid receptor DNA binding factor 1.	Rho guanine nucleotide exchange factor (GEF) 11.	0.436
ARHGAP35	ARHGEF12	ENSPTRP00000075057	ENSPTRP00000058269	Glucocorticoid receptor DNA binding factor 1.	Rho guanine nucleotide exchange factor (GEF) 12.	0.420
ARHGAP35	ERBB2	ENSPTRP00000075057	ENSPTRP00000069840	Glucocorticoid receptor DNA binding factor 1.	Receptor protein-tyrosine kinase.	0.432
ARHGAP35	MET	ENSPTRP00000075057	ENSPTRP00000083162	Glucocorticoid receptor DNA binding factor 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.629
ARHGAP35	PLXNB1	ENSPTRP00000075057	ENSPTRP00000025675	Glucocorticoid receptor DNA binding factor 1.	PLXNB1 isoform 1.	0.497
ARHGAP35	RAC1	ENSPTRP00000075057	ENSPTRP00000068561	Glucocorticoid receptor DNA binding factor 1.	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.465
ARHGAP35	RAC1-2	ENSPTRP00000075057	ENSPTRP00000084384	Glucocorticoid receptor DNA binding factor 1.	Rac family small GTPase 1.	0.465
ARHGAP35	RHOA	ENSPTRP00000075057	ENSPTRP00000025759	Glucocorticoid receptor DNA binding factor 1.	Ras homolog family member A.	0.995
ARHGAP35	RHOB	ENSPTRP00000075057	ENSPTRP00000066459	Glucocorticoid receptor DNA binding factor 1.	Ras homolog gene family, member B.	0.843
ARHGAP35	RHOC	ENSPTRP00000075057	ENSPTRP00000071746	Glucocorticoid receptor DNA binding factor 1.	Rho-related GTP-binding protein RhoC isoform X1.	0.901
ARHGAP35	RND1	ENSPTRP00000075057	ENSPTRP00000008358	Glucocorticoid receptor DNA binding factor 1.	RND1 isoform 1.	0.868
ARHGAP35	ROCK1	ENSPTRP00000075057	ENSPTRP00000084841	Glucocorticoid receptor DNA binding factor 1.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...]	0.601
ARHGAP35	SEMA4D	ENSPTRP00000075057	ENSPTRP00000049238	Glucocorticoid receptor DNA binding factor 1.	SEMA4D isoform 13; Belongs to the semaphorin family.	0.547
ARHGEF11	ARHGAP35	ENSPTRP00000091210	ENSPTRP00000075057	Rho guanine nucleotide exchange factor (GEF) 11.	Glucocorticoid receptor DNA binding factor 1.	0.436
ARHGEF11	ARHGEF12	ENSPTRP00000091210	ENSPTRP00000058269	Rho guanine nucleotide exchange factor (GEF) 11.	Rho guanine nucleotide exchange factor (GEF) 12.	0.959
ARHGEF11	ERBB2	ENSPTRP00000091210	ENSPTRP00000069840	Rho guanine nucleotide exchange factor (GEF) 11.	Receptor protein-tyrosine kinase.	0.503
ARHGEF11	MET	ENSPTRP00000091210	ENSPTRP00000083162	Rho guanine nucleotide exchange factor (GEF) 11.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.468
ARHGEF11	PLXNB1	ENSPTRP00000091210	ENSPTRP00000025675	Rho guanine nucleotide exchange factor (GEF) 11.	PLXNB1 isoform 1.	0.943
ARHGEF11	RAC1	ENSPTRP00000091210	ENSPTRP00000068561	Rho guanine nucleotide exchange factor (GEF) 11.	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.425
ARHGEF11	RAC1-2	ENSPTRP00000091210	ENSPTRP00000084384	Rho guanine nucleotide exchange factor (GEF) 11.	Rac family small GTPase 1.	0.425