STRINGSTRING
ARHGEF16 ARHGEF16 ARHGEF19 ARHGEF19 GNG4 GNG4 GNG3 GNG3 GNB5 GNB5 ABR ABR GNA13 GNA13 VAV1 VAV1 ARHGEF1 ARHGEF1 ARHGEF4 ARHGEF4 SESTD1 SESTD1 NGEF NGEF TGM3 TGM3 ADRA1D ADRA1D TIAM1 TIAM1 PLXNB1 PLXNB1 RHOA RHOA GNB4 GNB4 CK820_G0024137 CK820_G0024137 TRIO TRIO RASGRF2 RASGRF2 ARHGEF37 ARHGEF37 ADRA1B ADRA1B FGD2 FGD2 GNA12 GNA12 GNGT1 GNGT1 GNG11 GNG11 ARHGEF5 ARHGEF5 ARHGEF39 ARHGEF39 GNG10 GNG10 FGD1 FGD1 BTK BTK PLEKHG5 PLEKHG5 AKAP13 AKAP13 ARHGEF6 ARHGEF6 ARHGEF18 ARHGEF18 SOS2 SOS2 GNB3 GNB3 ARHGEF15 ARHGEF15 ARHGEF40 ARHGEF40 ECT2L ECT2L SOS1 SOS1 ARHGEF12 ARHGEF12 GNGT2 GNGT2 ARHGEF10L ARHGEF10L PLEKHG2 PLEKHG2 ARHGEF7 ARHGEF7 GNG12 GNG12 TBXA2R TBXA2R MCF2 MCF2 ARHGEF3 ARHGEF3 GNG13 GNG13 FGD3 FGD3 ROCK2 ROCK2 NET1 NET1 GNG2 GNG2 CK820_G0050308 CK820_G0050308 RHOB RHOB GNB1 GNB1 OBSCN OBSCN GNG7 GNG7 TGM6 TGM6 ARHGEF2 ARHGEF2 ENSPTRP00000071036 ENSPTRP00000071036 RHOC RHOC ARHGEF10 ARHGEF10 ENSPTRP00000072507 ENSPTRP00000072507 ECT2 ECT2 ARHGEF38 ARHGEF38 TIAM2 TIAM2 PREX1 PREX1 ITSN1 ITSN1 FGD4 FGD4 CK820_G0036362 CK820_G0036362 VAV2 VAV2 ADRA1A ADRA1A ROCK1 ROCK1 GNB2 GNB2 KALRN KALRN MCF2L2 MCF2L2 MCF2L-2 MCF2L-2 ARHGEF33 ARHGEF33 VAV3 VAV3 GNG8 GNG8 ARHGEF17 ARHGEF17 ARHGEF11 ARHGEF11 ARHGEF9 ARHGEF9 ITSN1-2 ITSN1-2 GNB2-2 GNB2-2 ENSPTRP00000093443 ENSPTRP00000093443 ARHGEF26 ARHGEF26 CK820_G0040666 CK820_G0040666 MCF2L MCF2L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF16ARHGEF16 isoform 1. (701 aa)
ARHGEF19Rho guanine nucleotide exchange factor (GEF) 19. (804 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB5GNB5 isoform 1. (409 aa)
ABRActive BCR-related protein. (840 aa)
GNA13Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (1876 aa)
SESTD1SEC14 and spectrin domain containing 1. (696 aa)
NGEFNeuronal guanine nucleotide exchange factor. (710 aa)
TGM3Transglutaminase 3. (693 aa)
ADRA1DADRA1D isoform 1. (568 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
PLXNB1PLXNB1 isoform 1. (2135 aa)
RHOARas homolog family member A. (193 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
CK820_G0024137ARHGEF38 isoform 4. (547 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3096 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
ARHGEF37ARHGEF37 isoform 2. (817 aa)
ADRA1BADRA1B isoform 3. (518 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (655 aa)
GNA12Guanine nucleotide binding protein (G protein) alpha 12. (381 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ARHGEF5ARHGEF5 isoform 2. (1597 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (961 aa)
BTKBTK isoform 2. (693 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1082 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (783 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X6. (1015 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GNB3G protein subunit beta 3. (340 aa)
ARHGEF15ARHGEF15 isoform 3. (841 aa)
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 40. (1519 aa)
ECT2LEpithelial cell transforming 2 like. (904 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
ARHGEF10LARHGEF10L isoform 1. (1278 aa)
PLEKHG2Pleckstrin homology domain containing, family G (With RhoGef domain) member 2. (1386 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
MCF2MCF2 isoform 7. (1044 aa)
ARHGEF3Rho guanine nucleotide exchange factor (GEF) 3. (558 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (725 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NET1Neuroepithelial cell transforming 1. (603 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
CK820_G0050308T0178126 isoform 1. (382 aa)
RHOBRas homolog gene family, member B. (286 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8919 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TGM6TGM6 isoform 1. (746 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ENSPTRP00000071036annotation not available (68 aa)
RHOCRho-related GTP-binding protein RhoC isoform X1. (196 aa)
ARHGEF10ARHGEF10 isoform 4. (1416 aa)
ENSPTRP00000072507annotation not available (659 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
ARHGEF38ARHGEF38 isoform 7. (219 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1730 aa)
PREX1Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa)
ITSN1ITSN1 isoform 4. (1721 aa)
FGD4FGD4 isoform 1. (914 aa)
CK820_G0036362MCF2L isoform 28. (83 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
MCF2L-2MCF2L isoform 7. (395 aa)
ARHGEF33ARHGEF33 isoform 1. (870 aa)
VAV3VAV3 isoform 2. (927 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ARHGEF17Rho guanine nucleotide exchange factor (GEF) 17. (2063 aa)
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
ARHGEF9ARHGEF9 isoform 17. (587 aa)
ITSN1-2ITSN1 isoform 7. (1716 aa)
GNB2-2G protein subunit beta 2. (372 aa)
ENSPTRP00000093443annotation not available (57 aa)
ARHGEF26Src homology 3 domain-containing guanine nucleotide exchange factor. (871 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
MCF2LMCF2L isoform 9. (1202 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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