STRINGSTRING
MYL9 MYL9 RHOA RHOA SEMA4D SEMA4D LIMK2 LIMK2 ARHGEF12 ARHGEF12 ROCK2 ROCK2 LOC468314 LOC468314 LIMK1 LIMK1 ARHGEF11 ARHGEF11 MYL6 MYL6 ROCK1 ROCK1 LIMK1-2 LIMK1-2 MYH9 MYH9 RHOC RHOC ENSPTRP00000064617 ENSPTRP00000064617 MYH14 MYH14 RHOB RHOB ENSPTRP00000069052 ENSPTRP00000069052 MYH10 MYH10 ERBB2 ERBB2 RND1 RND1 MYH11 MYH11 MYL12B MYL12B PLXNB1 PLXNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL9Myosin, light chain 9, regulatory. (172 aa)
RHOARas homolog family member A. (193 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
LIMK2LIMK2 isoform 6. (670 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
LOC468314MYL6 isoform 18. (116 aa)
LIMK1LIM domain kinase 1. (677 aa)
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
MYL6MYL6 isoform 8. (233 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
RHOCRho-related GTP-binding protein RhoC isoform X1. (196 aa)
ENSPTRP00000064617annotation not available (92 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
RHOBRas homolog gene family, member B. (286 aa)
ENSPTRP00000069052annotation not available (151 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
RND1RND1 isoform 1. (163 aa)
MYH11MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
MYL12BMyosin light chain 12B. (172 aa)
PLXNB1PLXNB1 isoform 1. (2135 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.