STRINGSTRING
GNG8 GNG8 SLC8A3 SLC8A3 ENSPTRP00000091352 ENSPTRP00000091352 KCNMB2 KCNMB2 NOS1 NOS1 PTGIR PTGIR ENSPTRP00000092364 ENSPTRP00000092364 CK820_G0029100 CK820_G0029100 GNB2-2 GNB2-2 SLC8A2 SLC8A2 ENSPTRP00000093443 ENSPTRP00000093443 CK820_G0040666 CK820_G0040666 TRPC7 TRPC7 REEP2 REEP2 KCNMB1 KCNMB1 ITPR3 ITPR3 MAPK14 MAPK14 PPP2R5D PPP2R5D GNGT1 GNGT1 GNG11 GNG11 NOS3 NOS3 REEP4 REEP4 GNG10 GNG10 CK820_G0047614 CK820_G0047614 PDE5A PDE5A ATP2A3 ATP2A3 ATP2B1 ATP2B1 GNB3 GNB3 PDE2A PDE2A P2RX7 P2RX7 PTPN6 PTPN6 APOB APOB P2RX5 P2RX5 TRPC3 TRPC3 REEP3 REEP3 CK820_G0015936 CK820_G0015936 GNAS GNAS GNGT2 GNGT2 PTPN11 PTPN11 KCNMA1 KCNMA1 P2RX3 P2RX3 GNG12 GNG12 GNG13 GNG13 PRKG2 PRKG2 PPP2CA PPP2CA GUCY1B1 GUCY1B1 SLC8A1 SLC8A1 LOC452727 LOC452727 ENSPTRP00000064286 ENSPTRP00000064286 GNG2 GNG2 ENSPTRP00000065717 ENSPTRP00000065717 ENSPTRP00000067174 ENSPTRP00000067174 GNB1 GNB1 ATP2B3 ATP2B3 PAFAH2 PAFAH2 FGR FGR LRP8 LRP8 PLA2G4A PLA2G4A GNG4 GNG4 PRKG1 PRKG1 MRVI1 MRVI1 GNG3 GNG3 PPP2R5B PPP2R5B TRPC6 TRPC6 PPP2R1B PPP2R1B PDE1B PDE1B ATP2A2 ATP2A2 GUCY1A1 GUCY1A1 GNB4 GNB4 ITPR1 ITPR1 ITPR2 ITPR2 P2RX6 P2RX6 PDE9A PDE9A CALM3 CALM3 NOS2 NOS2 P2RX1 P2RX1 ENSPTRP00000029492 ENSPTRP00000029492 LOC101056957 LOC101056957 GNB5 GNB5 PPP2R5C PPP2R5C ORAI1 ORAI1 P2RX4 P2RX4 GNG7 GNG7 ATP2B4 ATP2B4 ORAI2-2 ORAI2-2 ENSPTRP00000071036 ENSPTRP00000071036 KCNMB4 KCNMB4 PTPN11-2 PTPN11-2 GUCY1A2 GUCY1A2 PDE10A PDE10A ENSPTRP00000074534 ENSPTRP00000074534 ENSPTRP00000074763 ENSPTRP00000074763 ENSPTRP00000077211 ENSPTRP00000077211 STIM1 STIM1 ORAI3 ORAI3 ORAI2 ORAI2 PPP2R5A PPP2R5A SRI SRI PECAM1 PECAM1 SRI-2 SRI-2 PDE1A PDE1A ATP2A1 ATP2A1 P2RX2 P2RX2 PPP2R1A PPP2R1A GNB2 GNB2 ENSPTRP00000085296 ENSPTRP00000085296 ENSPTRP00000085680 ENSPTRP00000085680 ATP2B2 ATP2B2 PPP2R5E PPP2R5E PDE11A PDE11A PPP2CB PPP2CB ENSPTRP00000088414 ENSPTRP00000088414 CK820_G0024820 CK820_G0024820
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSPTRP00000091352annotation not available (87 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (263 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
PTGIRProstaglandin I2 (Prostacyclin) receptor (IP). (386 aa)
ENSPTRP00000092364annotation not available (574 aa)
CK820_G0029100SRI isoform 2. (98 aa)
GNB2-2G protein subunit beta 2. (372 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ENSPTRP00000093443annotation not available (57 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
REEP2Receptor expression-enhancing protein. (214 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
REEP4Receptor expression-enhancing protein. (257 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
CK820_G0047614T0168804 isoform 3. (207 aa)
PDE5APhosphodiesterase. (875 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1052 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
GNB3G protein subunit beta 3. (340 aa)
PDE2APhosphodiesterase. (941 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
APOBAPOB isoform 1. (4562 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (431 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
REEP3Receptor expression-enhancing protein. (255 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
GNASGNAS isoform 19. (1042 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
LOC452727Guanylate cyclase soluble subunit beta-2. (664 aa)
ENSPTRP00000064286annotation not available (260 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
ENSPTRP00000065717annotation not available (260 aa)
ENSPTRP00000067174annotation not available (502 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
PAFAH2Platelet-activating factor acetylhydrolase. (392 aa)
FGRTyrosine-protein kinase. (529 aa)
LRP8LDL receptor related protein 8. (960 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
MRVI1Murine retrovirus integration site 1 homolog. (912 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
TRPC6Transient receptor potential cation channel, subfamily C, member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
PDE1BPhosphodiesterase. (536 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (441 aa)
PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its abi [...] (603 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ENSPTRP00000029492annotation not available (223 aa)
LOC101056957T0109256 isoform 1. (3229 aa)
GNB5GNB5 isoform 1. (409 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
ORAI1ORAI1 isoform 1. (301 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ORAI2-2ORAI calcium release-activated calcium modulator 2. (262 aa)
ENSPTRP00000071036annotation not available (68 aa)
KCNMB4Potassium large conductance calcium-activated channel, subfamily M, beta member 4. (210 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (765 aa)
PDE10APhosphodiesterase. (856 aa)
ENSPTRP00000074534annotation not available (441 aa)
ENSPTRP00000074763annotation not available (520 aa)
ENSPTRP00000077211annotation not available (269 aa)
STIM1Stromal interaction molecule 1. (791 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (295 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (262 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
SRISRI isoform 1. (205 aa)
PECAM1Platelet/endothelial cell adhesion molecule. (745 aa)
SRI-2SRI isoform 5. (237 aa)
PDE1APhosphodiesterase. (572 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (497 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
ENSPTRP00000085296Uncharacterized protein LOC107966511 isoform X1. (87 aa)
ENSPTRP00000085680annotation not available (88 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
PDE11APhosphodiesterase. (985 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ENSPTRP00000088414annotation not available (529 aa)
CK820_G0024820PPP2R5C isoform 26. (479 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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