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PRKCA PRKCA GNB2-2 GNB2-2 GNA14 GNA14 PRKAR2A PRKAR2A GNG8 GNG8 CACNA2D2 CACNA2D2 THAP6 THAP6 ADCY6 ADCY6 GNA15 GNA15 CK820_G0040666 CK820_G0040666 ENSPTRP00000093443 ENSPTRP00000093443 CACNA2D1 CACNA2D1 STX1A-2 STX1A-2 CACNB3 CACNB3 STXBP1 STXBP1 PLCB3 PLCB3 GNB2 GNB2 RAP1A RAP1A ENSPTRP00000083779 ENSPTRP00000083779 CACNA1A CACNA1A ENSPTRP00000071036 ENSPTRP00000071036 ENSPTRP00000070111 ENSPTRP00000070111 CACNA1E CACNA1E GNG4 GNG4 CHRM3 CHRM3 GNG3 GNG3 CACNA1C CACNA1C RAPGEF3 RAPGEF3 ENSPTRP00000075783 ENSPTRP00000075783 ENSPTRP00000076429 ENSPTRP00000076429 CACNA1D CACNA1D ENSPTRP00000077377 ENSPTRP00000077377 ADCY8 ADCY8 INS INS SLC2A1 SLC2A1 KCNC2 KCNC2 CD36 CD36 GNA11 GNA11 GNAI1 GNAI1 KCNS3 KCNS3 SYT5 SYT5 FFAR1 FFAR1 PRKACA PRKACA KCNG2 KCNG2 PRKAR1B PRKAR1B GNG7 GNG7 PRKACG PRKACG GNG10 GNG10 CACNA1F CACNA1F ACSL4 ACSL4 PRKACB PRKACB CACNB2 CACNB2 GNB3 GNB3 GNGT1 GNGT1 STX1A STX1A MARCKS MARCKS GLP1R GLP1R PRKAR1A PRKAR1A ABCC8 ABCC8 KCNJ11 KCNJ11 GCG GCG GNAQ GNAQ AKAP5 AKAP5 RAPGEF5 RAPGEF5 GNG11 GNG11 VAMP2 VAMP2 GNAS GNAS ADRA2C ADRA2C PRKAR2B PRKAR2B GNGT2 GNGT2 ADRA2A ADRA2A RAPGEF4 RAPGEF4 GNG12 GNG12 GNG13 GNG13 GNG2 GNG2 AHCYL1 AHCYL1 ITPR3 ITPR3 GNB4 GNB4 GNB1 GNB1 RAPGEFL1 RAPGEFL1 SLC2A2 SLC2A2 ADCY5 ADCY5 GNAI2 GNAI2 PLCB2 PLCB2 GNB5 GNB5 IQGAP1 IQGAP1 ITPR1 ITPR1 ITPR2 ITPR2 THAP7 THAP7 KCNB1 KCNB1 SNAP25 SNAP25 PLCB1 PLCB1 ACSL3 ACSL3 FAP FAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNB2-2G protein subunit beta 2. (372 aa)
GNA14Guanine nucleotide binding protein (G protein), alpha 14. (355 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
THAP6THAP domain containing 6. (222 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
GNA15G protein subunit alpha 15. (374 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
ENSPTRP00000093443annotation not available (57 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
STX1A-2Syntaxin 1A. (344 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ENSPTRP00000083779annotation not available (309 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
ENSPTRP00000071036annotation not available (68 aa)
ENSPTRP00000070111annotation not available (324 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CHRM3Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). (590 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
ENSPTRP00000075783annotation not available (149 aa)
ENSPTRP00000076429annotation not available (110 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSPTRP00000077377annotation not available (149 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
SLC2A1Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
SYT5Synaptotagmin 5. (386 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (467 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
GNB3G protein subunit beta 3. (340 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
STX1ASTX1A isoform 3; Belongs to the syntaxin family. (288 aa)
MARCKSMyristoylated alanine-rich protein kinase C substrate. (332 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
ABCC8ABCC8 isoform 2. (1582 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
GCGGCG isoform 1. (180 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
VAMP2VAMP2 isoform 3. (118 aa)
GNASGNAS isoform 19. (1042 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
ADRA2AAdrenergic, alpha-2A-, receptor. (465 aa)
RAPGEF4RAPGEF4 isoform 2. (1011 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (662 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
GNB5GNB5 isoform 1. (409 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
THAP7THAP domain containing 7. (309 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; Belongs to the SNAP-25 family. (206 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ACSL3Acyl-CoA synthetase long-chain family member 3. (720 aa)
FAPFibroblast activation protein, alpha; Belongs to the peptidase S9B family. (760 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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