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LRRC27 LRRC27 TUT1 TUT1 DCPS DCPS DCP1B DCP1B DIS3L DIS3L EDC3 EDC3 WDR61 WDR61 PARN PARN CNOT1 CNOT1 EXOSC6 EXOSC6 EIF4A1 EIF4A1 NT5C3B NT5C3B HIGD1B HIGD1B LSM7 LSM7 C19H19orf54 C19H19orf54 TMC4 TMC4 CNOT11 CNOT11 PABPC1L PABPC1L LSM3 LSM3 EXOSC7 EXOSC7 XRN1 XRN1 EIF4G1 EIF4G1 EIF4A2 EIF4A2 CNOT6L CNOT6L LSM6 LSM6 TTC37 TTC37 CNOT8 CNOT8 LSM2 LSM2 LSM5 LSM5 CNOT4 CNOT4 EXOSC4 EXOSC4 EXOSC3 EXOSC3 PABPC4 PABPC4 CNOT3 CNOT3 PABPC3 PABPC3 EDC4 EDC4 DIS3L2 DIS3L2 DDX6 DDX6 TNKS1BP1 TNKS1BP1 SKIV2L SKIV2L EIF4E1B EIF4E1B PAIP1 PAIP1 TENT2 TENT2 EXOSC5 EXOSC5 EXOSC2 EXOSC2 EXOSC1 EXOSC1 LSM1 LSM1 DIS3 DIS3 EXOSC8 EXOSC8 PAN3 PAN3 MTPAP MTPAP CNOT2 CNOT2 PATL2 PATL2 CK820_G0038659 CK820_G0038659 EXOSC9 EXOSC9 CNOT9 CNOT9 EIF4A3 EIF4A3 ENSPTRP00000064065 ENSPTRP00000064065 ENSPTRP00000064242 ENSPTRP00000064242 PATL1 PATL1 TMC4-2 TMC4-2 CK820_G0037783 CK820_G0037783 LOC101056927 LOC101056927 PABPC4L PABPC4L EIF4E EIF4E PABPC1 PABPC1 CNOT6 CNOT6 LOC451932 LOC451932 TUT4 TUT4 ENSPTRP00000071121 ENSPTRP00000071121 CK820_G0023433 CK820_G0023433 CNOT10 CNOT10 ENSPTRP00000072738 ENSPTRP00000072738 ENSPTRP00000073400 ENSPTRP00000073400 EXOSC2-2 EXOSC2-2 PAN2 PAN2 LOC100612723 LOC100612723 ENSPTRP00000078236 ENSPTRP00000078236 CNOT7 CNOT7 ENSPTRP00000079261 ENSPTRP00000079261 ENSPTRP00000079840 ENSPTRP00000079840 ENSPTRP00000081975 ENSPTRP00000081975 LOC460549 LOC460549 CK820_G0020029 CK820_G0020029 ENSPTRP00000083112 ENSPTRP00000083112 TUT7 TUT7 TOE1 TOE1 ENSPTRP00000084822 ENSPTRP00000084822 ENSPTRP00000085332 ENSPTRP00000085332 ENSPTRP00000085447 ENSPTRP00000085447 CNOT3-2 CNOT3-2 PNLDC1 PNLDC1 CK820_G0044476 CK820_G0044476 HBS1L HBS1L DCP2 DCP2 LOC100611704 LOC100611704 LOC100609787 LOC100609787 ENSPTRP00000090582 ENSPTRP00000090582 ENSPTRP00000090981 ENSPTRP00000090981 ENSPTRP00000091556 ENSPTRP00000091556 LSM4 LSM4 EIF4A1-2 EIF4A1-2 ENSPTRP00000092190 ENSPTRP00000092190 DCP1A DCP1A EIF4B EIF4B KIFBP KIFBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRC27LRRC27 isoform 3. (530 aa)
TUT1Terminal uridylyl transferase 1, U6 snRNA-specific. (912 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
DCP1BDCP1B isoform 2. (621 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1054 aa)
EDC3Enhancer of mRNA decapping 3 homolog. (508 aa)
WDR61WD repeat domain 61. (305 aa)
PARNPARN isoform 1. (639 aa)
CNOT1CCR4-NOT transcription complex, subunit 1. (2383 aa)
EXOSC6Exosome complex component MTR3. (272 aa)
EIF4A1Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (406 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
HIGD1BHIG1 hypoxia inducible domain family member 1B. (99 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
C19H19orf54Chromosome 19 open reading frame 54. (351 aa)
TMC4Transmembrane channel-like protein. (706 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (510 aa)
PABPC1LPoly(A) binding protein cytoplasmic 1 like. (330 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
EXOSC7Exosome component 7. (291 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1559 aa)
EIF4A2Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (408 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (562 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
TTC37Tetratricopeptide repeat domain 37. (1564 aa)
CNOT8CCR4-NOT transcription complex, subunit 8. (292 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (712 aa)
EXOSC4Exosome component 4. (245 aa)
EXOSC3Exosome complex exonuclease RRP40. (275 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa)
CNOT3CCR4-NOT transcription complex, subunit 3. (753 aa)
PABPC3Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (633 aa)
EDC4Enhancer of mRNA decapping 4. (1401 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (887 aa)
DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; Belongs to the DEAD box helicase family. (483 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1729 aa)
SKIV2LSuperkiller viralicidic activity 2-like. (1246 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
PAIP1Poly(A) binding protein interacting protein 1. (479 aa)
TENT2PAPD4 isoform 1. (484 aa)
EXOSC5Exosome component 5. (235 aa)
EXOSC2Exosome component 2. (293 aa)
EXOSC1Exosome component 1. (195 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
EXOSC8Exosome component 8. (276 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (887 aa)
MTPAPMitochondrial poly(A) polymerase. (582 aa)
CNOT2CCR4-NOT transcription complex, subunit 2. (550 aa)
PATL2Protein PAT1 homolog 2 isoform X2. (545 aa)
CK820_G0038659CNOT7 isoform 10. (245 aa)
EXOSC9Exosome component 9. (456 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
ENSPTRP00000064065annotation not available (525 aa)
ENSPTRP00000064242annotation not available (213 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (727 aa)
TMC4-2Transmembrane channel like 4. (706 aa)
CK820_G0037783LSM5 isoform 6. (87 aa)
LOC101056927Eukaryotic translation initiation factor 4B pseudogene. (595 aa)
PABPC4LPABPC4L isoform 1. (430 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
CNOT6CCR4-NOT transcription complex, subunit 6. (557 aa)
LOC451932Eukaryotic initiation factor 4A-I pseudogene. (368 aa)
TUT4ZCCHC11 isoform 8. (1649 aa)
ENSPTRP00000071121annotation not available (425 aa)
CK820_G0023433EIF4A2 isoform 16. (92 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (804 aa)
ENSPTRP00000072738annotation not available (328 aa)
ENSPTRP00000073400annotation not available (59 aa)
EXOSC2-2Exosome component 2. (293 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
LOC100612723Polyadenylate-binding protein 1 pseudogene. (281 aa)
ENSPTRP00000078236annotation not available (522 aa)
CNOT7CCR4-NOT transcription complex, subunit 7. (285 aa)
ENSPTRP00000079261annotation not available (87 aa)
ENSPTRP00000079840annotation not available (349 aa)
ENSPTRP00000081975annotation not available (643 aa)
LOC460549EIF4B isoform 8. (594 aa)
CK820_G0020029PABPC1L isoform 9. (171 aa)
ENSPTRP00000083112annotation not available (413 aa)
TUT7ZCCHC6 isoform 2. (1540 aa)
TOE1Target of EGR1, member 1 (Nuclear). (523 aa)
ENSPTRP00000084822annotation not available (323 aa)
ENSPTRP00000085332annotation not available (174 aa)
ENSPTRP00000085447annotation not available (193 aa)
CNOT3-2CCR4-NOT transcription complex subunit 3. (753 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
CK820_G0044476CNOT6 isoform 4. (464 aa)
HBS1LHBS1 like translational GTPase. (698 aa)
DCP2DCP2 decapping enzyme homolog. (420 aa)
LOC100611704Polyadenylate-binding protein 1 pseudogene. (294 aa)
LOC100609787Eukaryotic initiation factor 4A-II pseudogene. (338 aa)
ENSPTRP00000090582annotation not available (96 aa)
ENSPTRP00000090981annotation not available (244 aa)
ENSPTRP00000091556annotation not available (277 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa)
EIF4A1-2Eukaryotic initiation factor 4A-I. (82 aa)
ENSPTRP00000092190annotation not available (433 aa)
DCP1ADCP1 decapping enzyme homolog A. (582 aa)
EIF4BEukaryotic translation initiation factor 4B. (615 aa)
KIFBPKIF1BP isoform 9. (646 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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