STRINGSTRING
PIK3CD PIK3CD YWHAZ YWHAZ RAPGEF1 RAPGEF1 ENSPTRP00000074763 ENSPTRP00000074763 SYK SYK PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 FYN FYN LOC100611246 LOC100611246 CK820_G0056611 CK820_G0056611 ENSPTRP00000081537 ENSPTRP00000081537 IL2RA IL2RA INPPL1 INPPL1 CBL CBL STAT5A STAT5A JAK2 JAK2 PTPN11-2 PTPN11-2 JAK1 JAK1 IL2RG IL2RG CRKL CRKL LYN LYN GAB2 GAB2 CSF2RA CSF2RA JAK3 JAK3 ENSPTRP00000029460 ENSPTRP00000029460 CSF2 CSF2 IL3 IL3 IL2 IL2 PIK3CB PIK3CB IL5RA IL5RA IL2RB IL2RB CSF2RB CSF2RB HCK HCK INPP5D INPP5D RPS27A RPS27A PIK3R2 PIK3R2 PRKACA PRKACA VAV1 VAV1 GRB2 GRB2 ENSPTRP00000092364 ENSPTRP00000092364 YES1 YES1 ENSPTRP00000089450 ENSPTRP00000089450 STAT5B STAT5B PIK3CA PIK3CA CRK CRK LOC101058095 LOC101058095 IL5 IL5 PTPN6 PTPN6 UBC UBC SHC1 SHC1 SOS1 SOS1 GAB4 GAB4 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 PTPN11 PTPN11 ENSPTRP00000063316 ENSPTRP00000063316 PIK3R3 PIK3R3 ENSPTRP00000067174 ENSPTRP00000067174 ENSPTRP00000067263 ENSPTRP00000067263 TEC-2 TEC-2 ENSPTRP00000071568 ENSPTRP00000071568 TEC TEC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
ENSPTRP00000074763annotation not available (520 aa)
SYKTyrosine-protein kinase. (635 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC10061124614-3-3 protein zeta/delta pseudogene. (212 aa)
CK820_G0056611IL3RA isoform 1. (278 aa)
ENSPTRP00000081537annotation not available (449 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IL2RGIL2RG isoform 1. (369 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
LYNTyrosine-protein kinase. (512 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
CSF2RACSF2RA isoform 11. (215 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (152 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
IL5RAInterleukin 5 receptor subunit alpha. (423 aa)
IL2RBInterleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
CSF2RBColony stimulating factor 2 receptor, beta, low-affinity (Granulocyte-macrophage). (904 aa)
HCKTyrosine-protein kinase. (526 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
RPS27ARPS27A isoform 1. (156 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ENSPTRP00000092364annotation not available (574 aa)
YES1Tyrosine-protein kinase. (558 aa)
ENSPTRP00000089450annotation not available (303 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
LOC10105809514-3-3 protein zeta/delta pseudogene. (238 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
GAB4GAB4 isoform 1. (685 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSPTRP00000063316annotation not available (235 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
ENSPTRP00000067174annotation not available (502 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
TEC-2Tec protein tyrosine kinase. (51 aa)
ENSPTRP00000071568annotation not available (98 aa)
TECTyrosine-protein kinase. (631 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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