STRINGSTRING
PSMC6 PSMC6 ENSPTRP00000090249 ENSPTRP00000090249 ENSPTRP00000090301 ENSPTRP00000090301 CDC73 CDC73 BOC BOC ENSPTRP00000091341 ENSPTRP00000091341 PSMD4 PSMD4 PSMB2 PSMB2 GLIS1 GLIS1 PSMB4 PSMB4 PSMA1 PSMA1 PSMC3 PSMC3 GRK2 GRK2 PSMD9 PSMD9 PSME1 PSME1 PSME2 PSME2 PSMA6 PSMA6 PSMA3 PSMA3 PSMC1 PSMC1 PSMA4 PSMA4 PSMD7 PSMD7 GAS8 GAS8 ARRB2 ARRB2 PSMD11 PSMD11 PSMD3 PSMD3 SPOP SPOP PSMA8 PSMA8 PSMD8 PSMD8 RPS27A RPS27A SPOPL SPOPL PSMD14 PSMD14 IHH IHH CUL3 CUL3 PSMD1 PSMD1 PSMF1 PSMF1 PSMA7 PSMA7 RBX1 RBX1 PSMD6 PSMD6 PSMD2 PSMD2 EVC2 EVC2 HHIP HHIP PSMB8 PSMB8 PSMB9 PSMB9 PSMB1 PSMB1 GLI3 GLI3 PSMC2 PSMC2 SMO SMO GLIS3 GLIS3 PSMB7 PSMB7 ARR3 ARR3 GLI2 GLI2 ITCH ITCH ARRB1 ARRB1 PSMD10 PSMD10 PSMB10 PSMB10 NUMB NUMB SMURF1 SMURF1 PSMA2 PSMA2 TEX52 TEX52 UBC UBC EFCAB7 EFCAB7 DZIP1 DZIP1 EVC EVC ENSPTRP00000054503 ENSPTRP00000054503 PSMC5 PSMC5 CSNK1A1L CSNK1A1L KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 ULK3 ULK3 ENSPTRP00000062484 ENSPTRP00000062484 PSMD5 PSMD5 KIF3A KIF3A KIF3A-2 KIF3A-2 PSME3-2 PSME3-2 NUMBL NUMBL ENSPTRP00000064540 ENSPTRP00000064540 ENSPTRP00000065241 ENSPTRP00000065241 CSNK1A1 CSNK1A1 ENSPTRP00000066776 ENSPTRP00000066776 ENSPTRP00000067263 ENSPTRP00000067263 SMO-2 SMO-2 ENSPTRP00000067619 ENSPTRP00000067619 ENSPTRP00000067920 ENSPTRP00000067920 PSMB6 PSMB6 DZIP1L DZIP1L CDON CDON ENSPTRP00000069172 ENSPTRP00000069172 PSMB3 PSMB3 IQCE IQCE ENSPTRP00000071568 ENSPTRP00000071568 LOC470312 LOC470312 PSMD13 PSMD13 ENSPTRP00000073673 ENSPTRP00000073673 SUFU SUFU ENSPTRP00000074972 ENSPTRP00000074972 DHH DHH SHH SHH ENSPTRP00000076582 ENSPTRP00000076582 GAS1 GAS1 ENSPTRP00000077985 ENSPTRP00000077985 GLI1 GLI1 LOC461963 LOC461963 PSMD12 PSMD12 PSMA5 PSMA5 CK820_G0002453 CK820_G0002453 ENSPTRP00000082443 ENSPTRP00000082443 PSME4 PSME4 ENSPTRP00000083999 ENSPTRP00000083999 ENSPTRP00000084513 ENSPTRP00000084513 ENSPTRP00000085348 ENSPTRP00000085348 PSME3 PSME3 ENSPTRP00000086535 ENSPTRP00000086535 LOC101059795 LOC101059795 PSMC4 PSMC4 PTCH1 PTCH1 GPR161 GPR161 SMURF2 SMURF2 PSMB5 PSMB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa)
ENSPTRP00000090249annotation not available (96 aa)
ENSPTRP00000090301annotation not available (443 aa)
CDC73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1115 aa)
ENSPTRP00000091341annotation not available (379 aa)
PSMD4PSMD4 isoform 2. (382 aa)
PSMB2Proteasome subunit beta. (201 aa)
GLIS1GLIS1 isoform 1. (861 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMC3Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
PSMD9Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 9. (223 aa)
PSME1Proteasome (Prosome, macropain) activator subunit 1 (PA28 alpha). (250 aa)
PSME2Proteasome (Prosome, macropain) activator subunit 2 (PA28 beta). (239 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC1Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
PSMA4Proteasome subunit alpha type-4 isoform X2. (261 aa)
PSMD7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa)
GAS8Growth arrest-specific 8. (537 aa)
ARRB2ARRB2 isoform 2. (430 aa)
PSMD11Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
PSMD3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
PSMD8Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 8. (350 aa)
RPS27ARPS27A isoform 1. (156 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
PSMD14Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
CUL3CUL3 isoform 2; Belongs to the cullin family. (768 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMF1Proteasome (Prosome, macropain) inhibitor subunit 1 (PI31). (271 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
PSMD6Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
EVC2EvC ciliary complex subunit 2. (1308 aa)
HHIPHedgehog interacting protein. (700 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (218 aa)
PSMB1Proteasome subunit beta. (241 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
PSMC2Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLIS3GLIS family zinc finger 3. (930 aa)
PSMB7Proteasome subunit beta. (277 aa)
ARR3ARR3 isoform 1. (388 aa)
GLI2GLI family zinc finger 2. (1587 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ARRB1ARRB1 isoform 1. (418 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
PSMB10Proteasome subunit beta type-10. (273 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TEX52Testis expressed 52. (305 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
DZIP1DZIP1 isoform 6. (866 aa)
EVCEVC isoform 1. (991 aa)
ENSPTRP00000054503annotation not available (205 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
ULK3Unc-51 like kinase 3. (483 aa)
ENSPTRP00000062484annotation not available (224 aa)
PSMD5PSMD5 isoform 1. (509 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
KIF3A-2Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
NUMBLNUMBL isoform 1. (611 aa)
ENSPTRP00000064540annotation not available (358 aa)
ENSPTRP00000065241annotation not available (350 aa)
CSNK1A1Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
ENSPTRP00000066776annotation not available (570 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ENSPTRP00000067619annotation not available (224 aa)
ENSPTRP00000067920annotation not available (392 aa)
PSMB6Proteasome subunit beta. (244 aa)
DZIP1LDAZ interacting zinc finger protein 1 like. (767 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
ENSPTRP00000069172annotation not available (353 aa)
PSMB3Proteasome subunit beta. (205 aa)
IQCEIQCE isoform 2. (841 aa)
ENSPTRP00000071568annotation not available (98 aa)
LOC47031226S proteasome regulatory subunit 4 pseudogene. (374 aa)
PSMD13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
ENSPTRP00000073673annotation not available (196 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
ENSPTRP00000074972annotation not available (252 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000076582annotation not available (377 aa)
GAS1Growth arrest-specific 1. (370 aa)
ENSPTRP00000077985annotation not available (153 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LOC461963PSME2 isoform 10. (224 aa)
PSMD12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CK820_G0002453PSMC6 isoform 12. (340 aa)
ENSPTRP00000082443annotation not available (351 aa)
PSME4Proteasome (Prosome, macropain) activator subunit 4. (1844 aa)
ENSPTRP00000083999annotation not available (92 aa)
ENSPTRP00000084513annotation not available (205 aa)
ENSPTRP00000085348annotation not available (302 aa)
PSME3Proteasome activator subunit 3. (265 aa)
ENSPTRP00000086535annotation not available (351 aa)
LOC10105979526S proteasome non-ATPase regulatory subunit 2 pseudogene. (829 aa)
PSMC4Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
GPR161GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family. (543 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
PSMB5Proteasome subunit beta. (263 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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