STRINGSTRING
FGF19 FGF19 FGF4 FGF4 CBL CBL FGF23 FGF23 FGF9 FGF9 SPRY2 SPRY2 GRB2 GRB2 MKNK2 MKNK2 RPS27A RPS27A MAPK1 MAPK1 KLB KLB ENSPTRP00000029492 ENSPTRP00000029492 FGF1 FGF1 FGFR4 FGFR4 FGF17 FGF17 FGF16 FGF16 UBC UBC MAPK3 MAPK3 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 PTPN11 PTPN11 PPP2CA PPP2CA ENSPTRP00000067174 ENSPTRP00000067174 ENSPTRP00000067263 ENSPTRP00000067263 FGF2 FGF2 ENSPTRP00000071568 ENSPTRP00000071568 PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 FGF8 FGF8 SRC SRC ENSPTRP00000077211 ENSPTRP00000077211 MKNK1 MKNK1 BRAF BRAF PPP2R1A PPP2R1A FNDC3A FNDC3A FNDC3B FNDC3B FGF6 FGF6 FGF20 FGF20 PPP2CB PPP2CB BRAF-2 BRAF-2 FRS2 FRS2 ENSPTRP00000090382 ENSPTRP00000090382 FGF18 FGF18 ENSPTRP00000092364 ENSPTRP00000092364
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty homolog 2. (338 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MKNK2MAP kinase interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
RPS27ARPS27A isoform 1. (156 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
KLBKLB isoform 1. (1044 aa)
ENSPTRP00000029492annotation not available (223 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
ENSPTRP00000067174annotation not available (502 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
ENSPTRP00000071568annotation not available (98 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000077211annotation not available (269 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
BRAF-2BRAF isoform 2. (766 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
ENSPTRP00000090382annotation not available (493 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSPTRP00000092364annotation not available (574 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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