STRINGSTRING
SPRED2 SPRED2 ENSPTRP00000092364 ENSPTRP00000092364 FGF18 FGF18 ENSPTRP00000090382 ENSPTRP00000090382 FRS2 FRS2 BRAF-2 BRAF-2 FGFRL1 FGFRL1 PPP2CB PPP2CB FGF20 FGF20 FGF6 FGF6 FNDC3B FNDC3B PIK3CA PIK3CA KRAS KRAS FNDC3A FNDC3A PPP2R1A PPP2R1A FGF10 FGF10 FRS3-2 FRS3-2 BRAF BRAF MKNK1 MKNK1 ENSPTRP00000077211 ENSPTRP00000077211 PIK3R1 PIK3R1 SRC SRC FGF8 FGF8 ENSPTRP00000074763 ENSPTRP00000074763 PTPN11-2 PTPN11-2 ENSPTRP00000071568 ENSPTRP00000071568 CSDE1 CSDE1 FLRT2 FLRT2 FGF2 FGF2 ENSPTRP00000067263 ENSPTRP00000067263 ENSPTRP00000067174 ENSPTRP00000067174 FGFR1 FGFR1 FGF22 FGF22 ERAS ERAS PPP2CA PPP2CA PTPN11 PTPN11 ENSPTRP00000060412 ENSPTRP00000060412 KXD1 KXD1 MAPK3 MAPK3 SOS1 SOS1 SHC1 SHC1 UBC UBC FLRT1 FLRT1 FGF17 FGF17 ANOS1 ANOS1 FRS3 FRS3 FGF1 FGF1 ENSPTRP00000029492 ENSPTRP00000029492 GAB1 GAB1 FGF5 FGF5 MAPK1 MAPK1 PLCG1 PLCG1 FLRT3 FLRT3 RPS27A RPS27A MKNK2 MKNK2 GRB2 GRB2 SPRED1 SPRED1 SPRY2 SPRY2 KL KL FGF9 FGF9 FGF23 FGF23 CBL CBL FGF3 FGF3 FGF4 FGF4 HRAS HRAS NRAS NRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRED2SPRED2 isoform 3. (432 aa)
ENSPTRP00000092364annotation not available (574 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSPTRP00000090382annotation not available (493 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
BRAF-2BRAF isoform 2. (766 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS3-2Fibroblast growth factor receptor substrate 3. (492 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
ENSPTRP00000077211annotation not available (269 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SRCTyrosine-protein kinase. (542 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ENSPTRP00000074763annotation not available (520 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000071568annotation not available (98 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
ENSPTRP00000067174annotation not available (502 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
ERASES cell expressed Ras. (233 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSPTRP00000060412annotation not available (156 aa)
KXD1UBA52 isoform 10. (231 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ANOS1Anosmin 1. (680 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENSPTRP00000029492annotation not available (223 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
RPS27ARPS27A isoform 1. (156 aa)
MKNK2MAP kinase interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
SPRY2Sprouty homolog 2. (338 aa)
KLKL isoform 1. (1012 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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