STRINGSTRING
NRAS NRAS FGFBP3 FGFBP3 FGFR2 FGFR2 HRAS HRAS FGF4 FGF4 FGF3 FGF3 CBL CBL FGF23 FGF23 FGF9 FGF9 SPRY2 SPRY2 FGF7 FGF7 POLR2C POLR2C ESRP2 ESRP2 GRB2 GRB2 MKNK2 MKNK2 GTF2F1 GTF2F1 HNRNPM HNRNPM POLR2I POLR2I RPS27A RPS27A POLR2D POLR2D PLCG1 PLCG1 MAPK1 MAPK1 FGFBP1 FGFBP1 POLR2B POLR2B FGF5 FGF5 GAB1 GAB1 ENSPTRP00000029492 ENSPTRP00000029492 FGF1 FGF1 FRS3 FRS3 POLR2K POLR2K TIAL1 TIAL1 GTF2F2 GTF2F2 FGF17 FGF17 POLR2A POLR2A FGF16 FGF16 HNRNPF HNRNPF UBC UBC SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 RBFOX2 RBFOX2 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 HNRNPA1L2 HNRNPA1L2 LOC746306 LOC746306 PTPN11 PTPN11 POLR2F POLR2F NCBP1 NCBP1 PPP2CA PPP2CA ERAS ERAS ENSPTRP00000064797 ENSPTRP00000064797 FGF22 FGF22 ENSPTRP00000067174 ENSPTRP00000067174 ENSPTRP00000067263 ENSPTRP00000067263 FGF2 FGF2 POLR2L POLR2L CSDE1 CSDE1 ENSPTRP00000071568 ENSPTRP00000071568 LOC107975110 LOC107975110 POLR2G POLR2G PTPN11-2 PTPN11-2 POLR2E POLR2E PTBP3 PTBP3 ENSPTRP00000074763 ENSPTRP00000074763 POLR2H POLR2H FGF8 FGF8 PTBP1 PTBP1 SRC SRC PIK3R1 PIK3R1 TIA1 TIA1 ENSPTRP00000077211 ENSPTRP00000077211 MKNK1 MKNK1 BRAF BRAF FRS3-2 FRS3-2 NCBP2 NCBP2 POLR2J POLR2J FGF10 FGF10 PPP2R1A PPP2R1A FNDC3A FNDC3A KRAS KRAS PIK3CA PIK3CA FNDC3B FNDC3B FGF6 FGF6 FGF20 FGF20 HNRNPA1 HNRNPA1 PTBP2 PTBP2 PPP2CB PPP2CB ENSPTRP00000088111 ENSPTRP00000088111 LOC467485 LOC467485 ENSPTRP00000088994 ENSPTRP00000088994 BRAF-2 BRAF-2 ESRP1 ESRP1 FRS2 FRS2 ENSPTRP00000090382 ENSPTRP00000090382 CK820_G0044510 CK820_G0044510 FGF18 FGF18 ENSPTRP00000091747 ENSPTRP00000091747 ENSPTRP00000092364 ENSPTRP00000092364 HNRNPH1 HNRNPH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
FGFBP3Fibroblast growth factor binding protein 3. (258 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty homolog 2. (338 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
POLR2CPolymerase (RNA) II (DNA directed) polypeptide C, 33kDa. (275 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MKNK2MAP kinase interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
HNRNPMHeterogeneous nuclear ribonucleoprotein M. (730 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
RPS27ARPS27A isoform 1. (156 aa)
POLR2DPolymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
ENSPTRP00000029492annotation not available (223 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
POLR2KPolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa. (58 aa)
TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1. (375 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1960 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HNRNPFHeterogeneous nuclear ribonucleoprotein F. (415 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RBFOX2RNA binding fox-1 homolog 2. (451 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
HNRNPA1L2HNRNPA1L2 isoform 1. (291 aa)
LOC746306Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. (320 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
NCBP1Nuclear cap binding protein subunit 1, 80kDa. (790 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
ERASES cell expressed Ras. (233 aa)
ENSPTRP00000064797annotation not available (144 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
ENSPTRP00000067174annotation not available (502 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSPTRP00000071568annotation not available (98 aa)
LOC107975110Heterogeneous nuclear ribonucleoprotein A1-like. (300 aa)
POLR2GPOLR2G isoform 2. (64 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
POLR2EPolymerase (RNA) II (DNA directed) polypeptide E, 25kDa. (210 aa)
PTBP3Polypyrimidine tract binding protein 3. (558 aa)
ENSPTRP00000074763annotation not available (520 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (196 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PTBP1PTBP1 isoform 2. (680 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
TIA1TIA1 cytotoxic granule-associated RNA binding protein. (386 aa)
ENSPTRP00000077211annotation not available (269 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
FRS3-2Fibroblast growth factor receptor substrate 3. (492 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (148 aa)
POLR2JPOLR2J2 isoform 2. (159 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HNRNPA1Heterogeneous nuclear ribonucleoprotein A1. (372 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ENSPTRP00000088111annotation not available (134 aa)
LOC467485Polypyrimidine tract-binding protein 1-like. (488 aa)
ENSPTRP00000088994annotation not available (135 aa)
BRAF-2BRAF isoform 2. (766 aa)
ESRP1Epithelial splicing regulatory protein 1. (681 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
ENSPTRP00000090382annotation not available (493 aa)
CK820_G0044510HNRNPH1 isoform 48. (373 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSPTRP00000091747annotation not available (340 aa)
ENSPTRP00000092364annotation not available (574 aa)
HNRNPH1HNRNPH1 isoform 31. (472 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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