STRINGSTRING
PIK3CD PIK3CD LCK LCK FAM102B FAM102B PIK3AP1 PIK3AP1 FGFR2 FGFR2 TRAF6 TRAF6 FNBP4 FNBP4 PPP2R5B PPP2R5B FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 PPP2R1B PPP2R1B FGF23 FGF23 IRAK4 IRAK4 ERBB3 ERBB3 KITLG KITLG FGF9 FGF9 FLT3 FLT3 KL KL IRS2 IRS2 STRN STRN ESR2 ESR2 PPP2R5C PPP2R5C FGF7 FGF7 CD276 CD276 SPEM1 SPEM1 SPEM2 SPEM2 PIP4K2B PIP4K2B GRB2 GRB2 PIP5K1C PIP5K1C VAV1 VAV1 PIK3R2 PIK3R2 FLT3LG FLT3LG CD28 CD28 ICOS ICOS IRS1 IRS1 MAPK1 MAPK1 PDGFB PDGFB TRAT1 TRAT1 CD80 CD80 CD86 CD86 PIK3CB PIK3CB KLB KLB PDGFRA PDGFRA KIT KIT EPGN EPGN EREG EREG BTC BTC FGF5 FGF5 EGF EGF GAB1 GAB1 ENSPTRP00000029492 ENSPTRP00000029492 HBEGF HBEGF FGF1 FGF1 FGFR4 FGFR4 PPP2R5D PPP2R5D ESR1 ESR1 IL33 IL33 IRAK1-2 IRAK1-2 NRG2 NRG2 FGF17 FGF17 STRN3 STRN3 FGF16 FGF16 GAB2 GAB2 INSC INSC RHOG RHOG FAM102A FAM102A PIP5KL1 PIP5KL1 PPP4R1 PPP4R1 WDR64 WDR64 MAPK3 MAPK3 GAB4 GAB4 PDGFA PDGFA PTPN11 PTPN11 AREG AREG MYD88 MYD88 INSR INSR ERBB4 ERBB4 PPP2CA PPP2CA PIK3R3 PIK3R3 ENSPTRP00000064286 ENSPTRP00000064286 ENSPTRP00000065244 ENSPTRP00000065244 ENSPTRP00000065717 ENSPTRP00000065717 FGF22 FGF22 FGFR1 FGFR1 LOC459462 LOC459462 ENSPTRP00000067174 ENSPTRP00000067174 FGF2 FGF2 RAC1 RAC1 IRAK1 IRAK1 RAC2 RAC2 ENSPTRP00000069368 ENSPTRP00000069368 EGFR EGFR ERBB2 ERBB2 PIP5K1B PIP5K1B NRG3 NRG3 PIP4K2A PIP4K2A HGF HGF PTPN11-2 PTPN11-2 PIP5K1A PIP5K1A ENSPTRP00000074763 ENSPTRP00000074763 ENSPTRP00000075125 ENSPTRP00000075125 FGF8 FGF8 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 FYN FYN INS INS TGFA TGFA CD19 CD19 PPP2R5A PPP2R5A PDGFRB PDGFRB NRG4 NRG4 AKT1 AKT1 MET MET IL1RAP IL1RAP FGF10 FGF10 PPP2R1A PPP2R1A MORN2 MORN2 FNDC3A FNDC3A STRN4 STRN4 RAC1-2 RAC1-2 PIK3CA PIK3CA FNDC3B FNDC3B FGF6 FGF6 FGF20 FGF20 LOC100612020 LOC100612020 PPP2R5E PPP2R5E PIPSL PIPSL PPP2CB PPP2CB FGFR3 FGFR3 CK820_G0024820 CK820_G0024820 FRS2 FRS2 PIP4K2C PIP4K2C PPP4R4 PPP4R4 FGF18 FGF18 BANK1 BANK1 NRG1 NRG1 ENSPTRP00000092364 ENSPTRP00000092364 RELCH RELCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LCKTyrosine-protein kinase. (539 aa)
FAM102BFamily with sequence similarity 102, member B. (360 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
FNBP4Formin binding protein 4. (1019 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
KLKL isoform 1. (1012 aa)
IRS2IRS2 isoform 1. (1340 aa)
STRNStriatin, calmodulin binding protein. (780 aa)
ESR2Estrogen receptor 2. (530 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CD276CD276 isoform 13. (534 aa)
SPEM1Spermatid maturation 1. (309 aa)
SPEM2SPEM family member 2. (500 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase, type II, beta. (416 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (235 aa)
CD28CD28 isoform 3. (220 aa)
ICOSInducible T cell costimulator. (199 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KLBKLB isoform 1. (1044 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
EPGNEpithelial mitogen. (154 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
ENSPTRP00000029492annotation not available (223 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
IL33IL33 isoform 1. (270 aa)
IRAK1-2Interleukin-1 receptor-associated kinase 1. (712 aa)
NRG2NRG2 isoform 3. (859 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
STRN3Striatin, calmodulin binding protein 3. (797 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
INSCINSC spindle orientation adaptor protein. (579 aa)
RHOGRas homolog gene family, member G (Rho G). (191 aa)
FAM102AFamily with sequence similarity 102, member A. (384 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase-like 1. (394 aa)
PPP4R1Protein phosphatase 4, regulatory subunit 1. (950 aa)
WDR64WD repeat domain 64. (1080 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GAB4GAB4 isoform 1. (685 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
AREGAREG isoform 2. (274 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
ENSPTRP00000064286annotation not available (260 aa)
ENSPTRP00000065244annotation not available (463 aa)
ENSPTRP00000065717annotation not available (260 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
LOC459462Uncharacterized protein. (328 aa)
ENSPTRP00000067174annotation not available (502 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (207 aa)
ENSPTRP00000069368annotation not available (459 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
NRG3NRG3 isoform 3. (721 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase, type II, alpha. (406 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSPTRP00000074763annotation not available (520 aa)
ENSPTRP00000075125annotation not available (537 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
FYNTyrosine-protein kinase. (537 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
TGFATGFA isoform 6. (193 aa)
CD19CD19 isoform 1. (557 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NRG4NRG4 isoform 3. (117 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
MORN2MORN repeat containing 2. (79 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
STRN4Striatin, calmodulin binding protein 4. (760 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
LOC100612020Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (954 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
PIPSLPIP5K1A and PSMD4-like. (548 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
CK820_G0024820PPP2R5C isoform 26. (479 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase, type II, gamma. (421 aa)
PPP4R4Protein phosphatase 4, regulatory subunit 4. (873 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (785 aa)
NRG1NRG1 isoform 3. (713 aa)
ENSPTRP00000092364annotation not available (574 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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