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FNDC3A FNDC3A PIK3CA PIK3CA FNDC3B FNDC3B ARTN ARTN GFRA1 GFRA1 FRS2 FRS2 ENSPTRP00000092364 ENSPTRP00000092364 DOK6 DOK6 PIK3CD PIK3CD RET RET NXPE1 NXPE1 IRS2 IRS2 MAPK7 MAPK7 PRKCA PRKCA GRB2 GRB2 NRTN NRTN PRKACA PRKACA PIK3R2 PIK3R2 DOK1 DOK1 GFRA4 GFRA4 PLCG1 PLCG1 DOK5 DOK5 PIK3CB PIK3CB GAB1 GAB1 GFRA3 GFRA3 GFRA2 GFRA2 DOK2 DOK2 PRKACG PRKACG PRKACB PRKACB GAB2 GAB2 NXPE2 NXPE2 NXPE4 NXPE4 GDNF GDNF SHC1 SHC1 SOS1 SOS1 GAB4 GAB4 GRB10 GRB10 PTPN11 PTPN11 ENSPTRP00000063424 ENSPTRP00000063424 SHANK3 SHANK3 SHC3 SHC3 PIK3R3 PIK3R3 DOK4 DOK4 RAP1GAP RAP1GAP ENSPTRP00000065059 ENSPTRP00000065059 ENSPTRP00000067174 ENSPTRP00000067174 PSPN PSPN GRB7 GRB7 PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 PDLIM5 PDLIM5 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 PDLIM7 PDLIM7 LDB3 LDB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
ARTNARTN isoform 11. (235 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
ENSPTRP00000092364annotation not available (574 aa)
DOK6Docking protein 6. (331 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
NXPE1Neurexophilin and PC-esterase domain family member 1. (547 aa)
IRS2IRS2 isoform 1. (1340 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NRTNNRTN isoform 1. (197 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
DOK1Docking protein 1, 62kDa (Downstream of tyrosine kinase 1). (481 aa)
GFRA4GFRA4 isoform 1. (269 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
DOK5Docking protein 5. (306 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
GFRA3GDNF family receptor alpha 3. (400 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
DOK2Docking protein 2. (412 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
NXPE2Neurexophilin and PC-esterase domain family member 2. (559 aa)
NXPE4Neurexophilin and PC-esterase domain family member 4. (544 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
GAB4GAB4 isoform 1. (685 aa)
GRB10Growth factor receptor-bound protein 10. (594 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSPTRP00000063424annotation not available (1563 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
DOK4Docking protein 4. (330 aa)
RAP1GAPRAP1GAP isoform 8. (778 aa)
ENSPTRP00000065059annotation not available (454 aa)
ENSPTRP00000067174annotation not available (502 aa)
PSPNPSPN isoform 2. (156 aa)
GRB7Growth factor receptor bound protein 7. (555 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
PDLIM5PDLIM5 isoform 14. (625 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
PDLIM7PDZ and LIM domain 7 (Enigma). (459 aa)
LDB3LIM domain binding 3. (732 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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