STRINGSTRING
RAC1 RAC1 ENSPTRP00000068916 ENSPTRP00000068916 LAMB1 LAMB1 ITGB1 ITGB1 RAP1B RAP1B DOCK7 DOCK7 HGF HGF RAPGEF1 RAPGEF1 COL5A1 COL5A1 ENSPTRP00000076429 ENSPTRP00000076429 SRC SRC ITGA2 ITGA2 MET MET CRK CRK PTK2 PTK2 FNDC3A FNDC3A RAC1-2 RAC1-2 RAP1A RAP1A FNDC3B FNDC3B LAMA1 LAMA1 COL11A1 COL11A1 LAMC3 LAMC3 ENSPTRP00000089450 ENSPTRP00000089450 LAMA5 LAMA5 TNS4 TNS4 LAMA4 LAMA4 LAMC1 LAMC1 LAMC2 LAMC2 ITGA3 ITGA3 COL1A1 COL1A1 GRB2 GRB2 LAMA3 LAMA3 COL5A3 COL5A3 COL3A1 COL3A1 TNS1 TNS1 LAMB2 LAMB2 GAB1 GAB1 LAMA2 LAMA2 COL1A2 COL1A2 COL27A1 COL27A1 LAMB3 LAMB3 TNS3 TNS3 COL2A1 COL2A1 FN1 FN1 CRKL CRKL COL5A2 COL5A2 MEGF11 MEGF11 COL24A1 COL24A1 COL11A2 COL11A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
ENSPTRP00000068916annotation not available (99 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2129 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
ENSPTRP00000076429annotation not available (110 aa)
SRCTyrosine-protein kinase. (542 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
LAMC3Laminin subunit gamma 3. (1580 aa)
ENSPTRP00000089450annotation not available (303 aa)
LAMA5Laminin, alpha 5. (2203 aa)
TNS4TNS4 isoform 1. (715 aa)
LAMA4LAMA4 isoform 3. (1823 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
LAMC2LAMC2 isoform 1. (1193 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
COL5A3Collagen type V alpha 3 chain. (1745 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
TNS1TNS1 isoform 5. (1740 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
COL27A1COL27A1 isoform 1. (1860 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
TNS3TNS3 isoform 2. (1445 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
FN1FN1 isoform 1. (2477 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
COL24A1Collagen type XXIV alpha 1 chain. (1714 aa)
COL11A2COL11A2 isoform 2. (1736 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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