STRINGSTRING
SH3GL2 SH3GL2 EPS15 EPS15 STAM STAM CBL CBL SH3GL3 SH3GL3 CDH1 CDH1 GRB2 GRB2 HGS HGS SH3GL1 SH3GL1 RPS27A RPS27A CBLL1 CBLL1 CTNNB1 CTNNB1 UBC UBC KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 LOC468305 LOC468305 STAM2 STAM2 SRC SRC CTNND1 CTNND1 MET MET SH3KBP1 SH3KBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (896 aa)
STAMSignal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (540 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
RPS27ARPS27A isoform 1. (156 aa)
CBLL1Cas-Br-M (Murine) ecotropic retroviral transforming sequence-like 1. (491 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
LOC468305endophilin-A2 pseudogene. (385 aa)
STAM2Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (525 aa)
SRCTyrosine-protein kinase. (542 aa)
CTNND1CTNND1 isoform 23. (975 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
SH3KBP1SH3KBP1 isoform 2. (665 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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