STRINGSTRING
PSMC6 PSMC6 PSMD3 PSMD3 KAT2A KAT2A SMAD4 SMAD4 PSMD8 PSMD8 TGFB1 TGFB1 RPS27A RPS27A TCF7L1 TCF7L1 PSMD14 PSMD14 ITGA4 ITGA4 PSMD1 PSMD1 PSMF1 PSMF1 JAG1 JAG1 RBPJL RBPJL PSMA7 PSMA7 EP300 EP300 KAT2B KAT2B PSMD6 PSMD6 PSMD2 PSMD2 PSMB8 PSMB8 PSMB9 PSMB9 PSMB1 PSMB1 PSMC2 PSMC2 PSMB7 PSMB7 NOTCH1 NOTCH1 ZFHX4 ZFHX4 PSMD10 PSMD10 CTNNB1 CTNNB1 WWTR1 WWTR1 PSMB10 PSMB10 HES4 HES4 SMURF1 SMURF1 PSMA2 PSMA2 FOXO3 FOXO3 UBC UBC ITGAL ITGAL ZFHX2 ZFHX2 ENSPTRP00000054503 ENSPTRP00000054503 PSME3 PSME3 CCND1 CCND1 ENSPTRP00000086535 ENSPTRP00000086535 LOC101059795 LOC101059795 PSMC4 PSMC4 ENSPTRP00000087746 ENSPTRP00000087746 SMURF2 SMURF2 PSMB5 PSMB5 BRD2 BRD2 PSMD11 PSMD11 CCN2 CCN2 ENSPTRP00000090249 ENSPTRP00000090249 SMAD3 SMAD3 PSME1 PSME1 PSMD9 PSMD9 TEAD4 TEAD4 YAP1 YAP1 MAML2 MAML2 BCL2L11 BCL2L11 NINJ2 NINJ2 MYC MYC CREBBP CREBBP ENSPTRP00000074972 ENSPTRP00000074972 CK820_G0042370 CK820_G0042370 ENSPTRP00000073673 ENSPTRP00000073673 HDAC4 HDAC4 PSMD13 PSMD13 LOC470312 LOC470312 ENSPTRP00000071568 ENSPTRP00000071568 PSMB3 PSMB3 ENSPTRP00000069172 ENSPTRP00000069172 PSMB6 PSMB6 ENSPTRP00000067920 ENSPTRP00000067920 ENSPTRP00000067263 ENSPTRP00000067263 MAMLD1 MAMLD1 ENSPTRP00000065241 ENSPTRP00000065241 SNW1 SNW1 ERAS ERAS ENSPTRP00000064540 ENSPTRP00000064540 HES1 HES1 PSME3-2 PSME3-2 PSMD5 PSMD5 ENSPTRP00000062484 ENSPTRP00000062484 PSMC3 PSMC3 PSMA1 PSMA1 PSMB4 PSMB4 PSMB2 PSMB2 RUNX3 RUNX3 PSME2 PSME2 ENSPTRP00000060412 ENSPTRP00000060412 CBFB CBFB ENSPTRP00000060300 ENSPTRP00000060300 CDKN1A CDKN1A KXD1 KXD1 MAML1 MAML1 PSMC5 PSMC5 ENSPTRP00000085348 ENSPTRP00000085348 FNDC3B FNDC3B KRAS KRAS ENSPTRP00000084513 ENSPTRP00000084513 FNDC3A FNDC3A TEAD1 TEAD1 TEAD2 TEAD2 RORC RORC ENSPTRP00000082443 ENSPTRP00000082443 ENSPTRP00000082196 ENSPTRP00000082196 TEAD3 TEAD3 ENSPTRP00000081714 ENSPTRP00000081714 MAMLD1-2 MAMLD1-2 TCF7L2 TCF7L2 TCF7 TCF7 CK820_G0002453 CK820_G0002453 LEF1 LEF1 PSMA5 PSMA5 MAML3 MAML3 PSMD12 PSMD12 RBPJ RBPJ LOC461963 LOC461963 ENSPTRP00000077985 ENSPTRP00000077985 SRC SRC ENSPTRP00000076582 ENSPTRP00000076582 RUNX1 RUNX1 SPP1 SPP1 ENSPTRP00000091341 ENSPTRP00000091341 PSMD4 PSMD4 PSMA6 PSMA6 PSMA3 PSMA3 PSMC1 PSMC1 PSMA4 PSMA4 ZFHX3 ZFHX3 PSMD7 PSMD7 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa)
PSMD3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PSMD8Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 8. (350 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RPS27ARPS27A isoform 1. (156 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
PSMD14Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMF1Proteasome (Prosome, macropain) inhibitor subunit 1 (PI31). (271 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
EP300E1A binding protein p300. (2175 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
PSMD6Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (218 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMC2Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa)
PSMB7Proteasome subunit beta. (277 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ZFHX4Zinc finger homeobox 4. (3615 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PSMB10Proteasome subunit beta type-10. (273 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
FOXO3FOXO3 isoform 1. (673 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
ITGALITGAL isoform 4. (344 aa)
ZFHX2ZFHX2 isoform 1. (2572 aa)
ENSPTRP00000054503annotation not available (205 aa)
PSME3Proteasome activator subunit 3. (265 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
ENSPTRP00000086535annotation not available (351 aa)
LOC10105979526S proteasome non-ATPase regulatory subunit 2 pseudogene. (829 aa)
PSMC4Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa)
ENSPTRP00000087746annotation not available (429 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
PSMB5Proteasome subunit beta. (263 aa)
BRD2Bromodomain containing 2. (835 aa)
PSMD11Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
CCN2CTGF isoform 1. (349 aa)
ENSPTRP00000090249annotation not available (96 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
PSME1Proteasome (Prosome, macropain) activator subunit 1 (PA28 alpha). (250 aa)
PSMD9Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 9. (223 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
YAP1Yes-associated protein 1. (508 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NINJ2NINJ2 isoform 1. (188 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
CREBBPCREB binding protein. (2442 aa)
ENSPTRP00000074972annotation not available (252 aa)
CK820_G0042370TEAD2 isoform 6. (427 aa)
ENSPTRP00000073673annotation not available (196 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
PSMD13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
LOC47031226S proteasome regulatory subunit 4 pseudogene. (374 aa)
ENSPTRP00000071568annotation not available (98 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSPTRP00000069172annotation not available (353 aa)
PSMB6Proteasome subunit beta. (244 aa)
ENSPTRP00000067920annotation not available (392 aa)
ENSPTRP00000067263Ubiquitin-large subunit ribosomal protein L40e. (119 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
ENSPTRP00000065241annotation not available (350 aa)
SNW1SNW domain containing 1. (571 aa)
ERASES cell expressed Ras. (233 aa)
ENSPTRP00000064540annotation not available (358 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
PSMD5PSMD5 isoform 1. (509 aa)
ENSPTRP00000062484annotation not available (224 aa)
PSMC3Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMB2Proteasome subunit beta. (201 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
PSME2Proteasome (Prosome, macropain) activator subunit 2 (PA28 beta). (239 aa)
ENSPTRP00000060412annotation not available (156 aa)
CBFBCore-binding factor, beta subunit. (182 aa)
ENSPTRP00000060300annotation not available (221 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
KXD1UBA52 isoform 10. (231 aa)
MAML1MAML1 isoform 1. (1016 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
ENSPTRP00000085348annotation not available (302 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ENSPTRP00000084513annotation not available (205 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
TEAD1TEAD1 isoform 6. (445 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
RORCRAR related orphan receptor C. (525 aa)
ENSPTRP00000082443annotation not available (351 aa)
ENSPTRP00000082196annotation not available (376 aa)
TEAD3TEA domain transcription factor 3. (435 aa)
ENSPTRP00000081714annotation not available (310 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
TCF7Transcription factor 7. (481 aa)
CK820_G0002453PSMC6 isoform 12. (340 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
MAML3MAML3 isoform 1. (1134 aa)
PSMD12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LOC461963PSME2 isoform 10. (224 aa)
ENSPTRP00000077985annotation not available (153 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000076582annotation not available (377 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
ENSPTRP00000091341annotation not available (379 aa)
PSMD4PSMD4 isoform 2. (382 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC1Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
PSMA4Proteasome subunit alpha type-4 isoform X2. (261 aa)
ZFHX3Zinc finger homeobox 3. (3688 aa)
PSMD7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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