20 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	ENSPTRP00000087746	annotation not available (429 aa)
	KAT2A	Histone acetyltransferase KAT2A isoform X1. (837 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1150 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	ENSPTRP00000081714	annotation not available (310 aa)
	MAMLD1-2	Mastermind-like domain containing 1. (722 aa)
	MAML3	MAML3 isoform 1. (1134 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	CREBBP	CREB binding protein. (2442 aa)
	MAMLD1	MAMLD1 isoform 3. (984 aa)
	SNW1	SNW domain containing 1. (571 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ENSPTRP00000060300	annotation not available (221 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	HES4	Hes family bHLH transcription factor 4. (221 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	EP300	E1A binding protein p300. (2175 aa)
	ENSPTRP00000082196	annotation not available (376 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	ENSPTRP00000081714	ENSPTRP00000074980	ENSPTRP00000081714	CREB binding protein.	annotation not available	0.654
CREBBP	ENSPTRP00000082196	ENSPTRP00000074980	ENSPTRP00000082196	CREB binding protein.	annotation not available	0.647
CREBBP	ENSPTRP00000087746	ENSPTRP00000074980	ENSPTRP00000087746	CREB binding protein.	annotation not available	0.647
CREBBP	EP300	ENSPTRP00000074980	ENSPTRP00000024841	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	KAT2A	ENSPTRP00000074980	ENSPTRP00000015659	CREB binding protein.	Histone acetyltransferase KAT2A isoform X1.	0.980
CREBBP	KAT2B	ENSPTRP00000074980	ENSPTRP00000025331	CREB binding protein.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.997
CREBBP	MAML1	ENSPTRP00000074980	ENSPTRP00000056639	CREB binding protein.	MAML1 isoform 1.	0.937
CREBBP	MAML2	ENSPTRP00000074980	ENSPTRP00000007220	CREB binding protein.	Mastermind like transcriptional coactivator 2.	0.926
CREBBP	MAML3	ENSPTRP00000074980	ENSPTRP00000079869	CREB binding protein.	MAML3 isoform 1.	0.879
CREBBP	MAMLD1	ENSPTRP00000074980	ENSPTRP00000065273	CREB binding protein.	MAMLD1 isoform 3.	0.442
CREBBP	MAMLD1-2	ENSPTRP00000074980	ENSPTRP00000081644	CREB binding protein.	Mastermind-like domain containing 1.	0.442
CREBBP	NOTCH1	ENSPTRP00000074980	ENSPTRP00000036924	CREB binding protein.	NOTCH1 isoform 1.	0.669
CREBBP	RBPJ	ENSPTRP00000074980	ENSPTRP00000079413	CREB binding protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.987
CREBBP	RUNX3	ENSPTRP00000074980	ENSPTRP00000000614	CREB binding protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.549
CREBBP	SNW1	ENSPTRP00000074980	ENSPTRP00000064690	CREB binding protein.	SNW domain containing 1.	0.654
ENSPTRP00000060300	ENSPTRP00000082196	ENSPTRP00000060300	ENSPTRP00000082196	annotation not available	annotation not available	0.428
ENSPTRP00000060300	ENSPTRP00000087746	ENSPTRP00000060300	ENSPTRP00000087746	annotation not available	annotation not available	0.428
ENSPTRP00000060300	RBPJ	ENSPTRP00000060300	ENSPTRP00000079413	annotation not available	Recombination signal binding protein for immunoglobulin kappa J region.	0.466
ENSPTRP00000081714	CREBBP	ENSPTRP00000081714	ENSPTRP00000074980	annotation not available	CREB binding protein.	0.654
ENSPTRP00000081714	ENSPTRP00000082196	ENSPTRP00000081714	ENSPTRP00000082196	annotation not available	annotation not available	0.765