10 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	CCND1	CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
	BRD2	Bromodomain containing 2. (835 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	EP300	E1A binding protein p300. (2175 aa)
	CBFB	Core-binding factor, beta subunit. (182 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRD2	EP300	ENSPTRP00000089370	ENSPTRP00000024841	Bromodomain containing 2.	E1A binding protein p300.	0.549
BRD2	HDAC4	ENSPTRP00000089370	ENSPTRP00000073000	Bromodomain containing 2.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.420
CBFB	EP300	ENSPTRP00000060319	ENSPTRP00000024841	Core-binding factor, beta subunit.	E1A binding protein p300.	0.735
CBFB	RUNX1	ENSPTRP00000060319	ENSPTRP00000092866	Core-binding factor, beta subunit.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.999
CBFB	RUNX3	ENSPTRP00000060319	ENSPTRP00000000614	Core-binding factor, beta subunit.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.996
CCND1	EP300	ENSPTRP00000086048	ENSPTRP00000024841	CCND1 isoform 1; Belongs to the cyclin family.	E1A binding protein p300.	0.933
CCND1	HDAC4	ENSPTRP00000086048	ENSPTRP00000073000	CCND1 isoform 1; Belongs to the cyclin family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.932
CCND1	KRAS	ENSPTRP00000086048	ENSPTRP00000084588	CCND1 isoform 1; Belongs to the cyclin family.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.686
CCND1	RUNX1	ENSPTRP00000086048	ENSPTRP00000092866	CCND1 isoform 1; Belongs to the cyclin family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.603
CCND1	RUNX3	ENSPTRP00000086048	ENSPTRP00000000614	CCND1 isoform 1; Belongs to the cyclin family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.698
CCND1	TGFB1	ENSPTRP00000086048	ENSPTRP00000018930	CCND1 isoform 1; Belongs to the cyclin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.508
EP300	BRD2	ENSPTRP00000024841	ENSPTRP00000089370	E1A binding protein p300.	Bromodomain containing 2.	0.549
EP300	CBFB	ENSPTRP00000024841	ENSPTRP00000060319	E1A binding protein p300.	Core-binding factor, beta subunit.	0.735
EP300	CCND1	ENSPTRP00000024841	ENSPTRP00000086048	E1A binding protein p300.	CCND1 isoform 1; Belongs to the cyclin family.	0.933
EP300	HDAC4	ENSPTRP00000024841	ENSPTRP00000073000	E1A binding protein p300.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.740
EP300	KRAS	ENSPTRP00000024841	ENSPTRP00000084588	E1A binding protein p300.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.554
EP300	RUNX1	ENSPTRP00000024841	ENSPTRP00000092866	E1A binding protein p300.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.893
EP300	RUNX3	ENSPTRP00000024841	ENSPTRP00000000614	E1A binding protein p300.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.818
EP300	TGFB1	ENSPTRP00000024841	ENSPTRP00000018930	E1A binding protein p300.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.671
HDAC4	BRD2	ENSPTRP00000073000	ENSPTRP00000089370	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Bromodomain containing 2.	0.420