node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRD2 | EP300 | ENSPTRP00000089370 | ENSPTRP00000024841 | Bromodomain containing 2. | E1A binding protein p300. | 0.549 |
BRD2 | HDAC4 | ENSPTRP00000089370 | ENSPTRP00000073000 | Bromodomain containing 2. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.420 |
CBFB | EP300 | ENSPTRP00000060319 | ENSPTRP00000024841 | Core-binding factor, beta subunit. | E1A binding protein p300. | 0.735 |
CBFB | RUNX1 | ENSPTRP00000060319 | ENSPTRP00000092866 | Core-binding factor, beta subunit. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.999 |
CBFB | RUNX3 | ENSPTRP00000060319 | ENSPTRP00000000614 | Core-binding factor, beta subunit. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.996 |
CCND1 | EP300 | ENSPTRP00000086048 | ENSPTRP00000024841 | CCND1 isoform 1; Belongs to the cyclin family. | E1A binding protein p300. | 0.933 |
CCND1 | HDAC4 | ENSPTRP00000086048 | ENSPTRP00000073000 | CCND1 isoform 1; Belongs to the cyclin family. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.932 |
CCND1 | KRAS | ENSPTRP00000086048 | ENSPTRP00000084588 | CCND1 isoform 1; Belongs to the cyclin family. | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. | 0.686 |
CCND1 | RUNX1 | ENSPTRP00000086048 | ENSPTRP00000092866 | CCND1 isoform 1; Belongs to the cyclin family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.603 |
CCND1 | RUNX3 | ENSPTRP00000086048 | ENSPTRP00000000614 | CCND1 isoform 1; Belongs to the cyclin family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.698 |
CCND1 | TGFB1 | ENSPTRP00000086048 | ENSPTRP00000018930 | CCND1 isoform 1; Belongs to the cyclin family. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.508 |
EP300 | BRD2 | ENSPTRP00000024841 | ENSPTRP00000089370 | E1A binding protein p300. | Bromodomain containing 2. | 0.549 |
EP300 | CBFB | ENSPTRP00000024841 | ENSPTRP00000060319 | E1A binding protein p300. | Core-binding factor, beta subunit. | 0.735 |
EP300 | CCND1 | ENSPTRP00000024841 | ENSPTRP00000086048 | E1A binding protein p300. | CCND1 isoform 1; Belongs to the cyclin family. | 0.933 |
EP300 | HDAC4 | ENSPTRP00000024841 | ENSPTRP00000073000 | E1A binding protein p300. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.740 |
EP300 | KRAS | ENSPTRP00000024841 | ENSPTRP00000084588 | E1A binding protein p300. | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. | 0.554 |
EP300 | RUNX1 | ENSPTRP00000024841 | ENSPTRP00000092866 | E1A binding protein p300. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.893 |
EP300 | RUNX3 | ENSPTRP00000024841 | ENSPTRP00000000614 | E1A binding protein p300. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.818 |
EP300 | TGFB1 | ENSPTRP00000024841 | ENSPTRP00000018930 | E1A binding protein p300. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.671 |
HDAC4 | BRD2 | ENSPTRP00000073000 | ENSPTRP00000089370 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | Bromodomain containing 2. | 0.420 |