STRINGSTRING
FMNL3 FMNL3 PREX1 PREX1 STOM STOM CK820_G0036362 CK820_G0036362 VAV2 VAV2 ARHGAP9 ARHGAP9 ROCK1 ROCK1 ENSPTRP00000085318 ENSPTRP00000085318 KALRN KALRN MCF2L2 MCF2L2 ENSPTRP00000086039 ENSPTRP00000086039 ARHGAP21 ARHGAP21 ARHGAP23 ARHGAP23 MCF2L-2 MCF2L-2 ARHGAP4 ARHGAP4 OPHN1 OPHN1 VAV3 VAV3 PREX2 PREX2 PCDH7 PCDH7 CLN8 CLN8 ARHGAP35 ARHGAP35 SCFD1 SCFD1 DIAPH1 DIAPH1 PIK3R1 PIK3R1 ARHGEF3 ARHGEF3 MCF2 MCF2 OLIG1 OLIG1 ARHGEF7 ARHGEF7 RRBP1 RRBP1 ARHGEF10L ARHGEF10L MYO9B MYO9B CCDC115 CCDC115 ARHGDIA ARHGDIA SOWAHC SOWAHC CAVIN1 CAVIN1 ROCK2 ROCK2 ERBIN ERBIN DEF6 DEF6 TJP2 TJP2 NET1 NET1 ARHGAP20 ARHGAP20 ENSPTRP00000065728 ENSPTRP00000065728 STARD8 STARD8 ABCD3 ABCD3 ENSPTRP00000066321 ENSPTRP00000066321 CK820_G0050308 CK820_G0050308 ENSPTRP00000066440 ENSPTRP00000066440 DIAPH3 DIAPH3 FLOT2 FLOT2 ARHGEF17 ARHGEF17 ENSPTRP00000090552 ENSPTRP00000090552 STX5 STX5 ARHGEF11 ARHGEF11 BCAP31 BCAP31 IPO11 IPO11 RNFT2 RNFT2 RTKN2 RTKN2 MCF2L MCF2L OBSCN OBSCN BCAP29 BCAP29 TGM6 TGM6 OLIG2 OLIG2 ARHGEF2 ARHGEF2 ARHGAP8 ARHGAP8 ENSPTRP00000071544 ENSPTRP00000071544 ARHGEF10 ARHGEF10 FAF2 FAF2 TMEM87A TMEM87A PLEKHG3 PLEKHG3 LOC739951 LOC739951 FARP1 FARP1 DAAM2 DAAM2 ARAP1 ARAP1 ARHGEF12 ARHGEF12 KTN1 KTN1 VAPB VAPB ARHGEF25 ARHGEF25 RHPN1 RHPN1 ARHGAP5 ARHGAP5 IQGAP3 IQGAP3 MACO1 MACO1 ARHGAP28 ARHGAP28 ARHGAP45 ARHGAP45 GMIP GMIP TFRC TFRC ARHGEF40 ARHGEF40 ARHGEF15 ARHGEF15 ARHGAP29 ARHGAP29 DDRGK1 DDRGK1 ARHGEF18 ARHGEF18 PLD1 PLD1 SRGAP1 SRGAP1 AKAP13 AKAP13 PLEKHG5 PLEKHG5 BCR BCR ATP6AP1 ATP6AP1 ARHGAP36 ARHGAP36 ARHGAP6 ARHGAP6 PKN3 PKN3 ARHGAP39 ARHGAP39 DLC1 DLC1 CAV1 CAV1 YKT6 YKT6 ANLN ANLN TAGAP TAGAP OLIG3 OLIG3 ARHGAP18 ARHGAP18 FLOT1 FLOT1 STK10 STK10 DOCK2 DOCK2 ARHGAP26 ARHGAP26 ARAP3 ARAP3 RASGRF2 RASGRF2 ARHGEF28 ARHGEF28 DEPDC1B DEPDC1B TRIO TRIO FHDC1 FHDC1 ARHGAP10 ARHGAP10 PGRMC2 PGRMC2 FAM13A FAM13A ARHGAP24 ARHGAP24 STBD1 STBD1 ARAP2 ARAP2 ARHGAP31 ARHGAP31 RHOA RHOA EMC3 EMC3 TIAM1 TIAM1 BHLHE23 BHLHE23 ARHGAP40 ARHGAP40 TGM3 TGM3 NGEF NGEF ARHGEF4 ARHGEF4 TMEM87B TMEM87B RTKN RTKN BCAM BCAM ARHGEF1 ARHGEF1 ARHGAP30 ARHGAP30 RHPN2 RHPN2 PIK3R2 PIK3R2 VAV1 VAV1 LMAN1 LMAN1 TEX2 TEX2 RNFT1 RNFT1 JUP JUP C1QBP C1QBP ABR ABR HMOX2 HMOX2 IQGAP1 IQGAP1 MYO9A MYO9A SNAP23 SNAP23 ARHGAP11A ARHGAP11A AAAS AAAS RACGAP1 RACGAP1 ARHGDIB ARHGDIB PLEKHG6 PLEKHG6 ARHGAP32 ARHGAP32 MCAM MCAM ARHGAP42 ARHGAP42 ARHGAP1 ARHGAP1 SLK SLK ARHGAP19 ARHGAP19 ARHGAP22 ARHGAP22 ACBD5 ACBD5 LBR LBR VANGL1 VANGL1 PKN2 PKN2 ARHGEF19 ARHGEF19 VAMP3 VAMP3 ECT2 ECT2 DAAM1 DAAM1 ARHGAP44 ARHGAP44 PKN1 PKN1 MAPK1IP1L MAPK1IP1L ENSPTRP00000079007 ENSPTRP00000079007 PLEKHG4 PLEKHG4 OLIG1-2 OLIG1-2 ENSPTRP00000080393 ENSPTRP00000080393 CIT CIT STARD13 STARD13
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FMNL3FMNL3 isoform 2. (1027 aa)
PREX1Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa)
STOMSTOM isoform 3. (288 aa)
CK820_G0036362MCF2L isoform 28. (83 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ARHGAP9Rho GTPase activating protein 9. (833 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ENSPTRP00000085318annotation not available (768 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
ENSPTRP00000086039annotation not available (570 aa)
ARHGAP21Rho GTPase activating protein 21. (1948 aa)
ARHGAP23ARHGAP23 isoform 2. (1491 aa)
MCF2L-2MCF2L isoform 7. (395 aa)
ARHGAP4Rho GTPase activating protein 4. (986 aa)
OPHN1Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). (810 aa)
VAV3VAV3 isoform 2. (927 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1620 aa)
PCDH7PCDH7 isoform 7. (1264 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
ARHGAP35Glucocorticoid receptor DNA binding factor 1. (1519 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (642 aa)
DIAPH1DIAPH1 isoform 4. (1278 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ARHGEF3Rho guanine nucleotide exchange factor (GEF) 3. (558 aa)
MCF2MCF2 isoform 7. (1044 aa)
OLIG1OLIG1 isoform 2. (272 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
RRBP1RRBP1 isoform 1. (1379 aa)
ARHGEF10LARHGEF10L isoform 1. (1278 aa)
MYO9BLOW QUALITY PROTEIN: unconventional myosin-IXb. (1987 aa)
CCDC115Coiled-coil domain containing 115. (193 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (249 aa)
SOWAHCSosondowah ankyrin repeat domain family member C. (529 aa)
CAVIN1Caveolae associated protein 1. (390 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ERBINErbb2 interacting protein. (1419 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
TJP2Tight junction protein 2; Belongs to the MAGUK family. (1249 aa)
NET1Neuroepithelial cell transforming 1. (603 aa)
ARHGAP20Rho GTPase activating protein 20. (1250 aa)
ENSPTRP00000065728annotation not available (516 aa)
STARD8StAR-related lipid transfer (START) domain containing 8. (1108 aa)
ABCD3ATP-binding cassette, sub-family D (ALD), member 3. (659 aa)
ENSPTRP00000066321annotation not available (227 aa)
CK820_G0050308T0178126 isoform 1. (382 aa)
ENSPTRP00000066440annotation not available (232 aa)
DIAPH3Diaphanous related formin 3. (1193 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (493 aa)
ARHGEF17Rho guanine nucleotide exchange factor (GEF) 17. (2063 aa)
ENSPTRP00000090552E3 ubiquitin-protein ligase RNFT1-like. (176 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (361 aa)
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
BCAP31BCAP31 isoform 3. (246 aa)
IPO11IPO11 isoform 4. (1015 aa)
RNFT2Ring finger protein, transmembrane 2. (444 aa)
RTKN2RTKN2 isoform 1. (609 aa)
MCF2LMCF2L isoform 9. (1202 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8919 aa)
BCAP29BCAP29 isoform 2. (330 aa)
TGM6TGM6 isoform 1. (746 aa)
OLIG2OLIG2 isoform 1. (323 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ARHGAP8PRR5-ARHGAP8 isoform 3. (464 aa)
ENSPTRP00000071544annotation not available (1118 aa)
ARHGEF10ARHGEF10 isoform 4. (1416 aa)
FAF2Fas associated factor family member 2. (450 aa)
TMEM87ATransmembrane protein 87A. (555 aa)
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1219 aa)
LOC739951Rho GTPase-activating protein 21-like. (1874 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1076 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1419 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
KTN1KTN1 isoform 4. (1357 aa)
VAPBVAMP (Vesicle-associated membrane protein)-associated protein B and C. (243 aa)
ARHGEF25Rho guanine nucleotide exchange factor (GEF) 25. (619 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (670 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1589 aa)
MACO1Macoilin; Plays a role in the regulation of neuronal activity. (664 aa)
ARHGAP28Rho GTPase activating protein 28. (729 aa)
ARHGAP45ARHGAP45 isoform 3. (1152 aa)
GMIPGEM interacting protein. (970 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 40. (1519 aa)
ARHGEF15ARHGEF15 isoform 3. (841 aa)
ARHGAP29Rho GTPase activating protein 29. (1261 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X6. (1015 aa)
PLD1Phospholipase. (1074 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1082 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
ARHGAP36Rho GTPase activating protein 36. (535 aa)
ARHGAP6Rho GTPase activating protein 6. (974 aa)
PKN3Protein kinase N3. (889 aa)
ARHGAP39Rho GTPase activating protein 39. (1114 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
ANLNAnillin, actin binding protein. (1125 aa)
TAGAPT cell activation RhoGTPase activating protein. (731 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
ARHGAP18Rho GTPase activating protein 18. (663 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
STK10Serine/threonine kinase 10. (968 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
ARHGAP26Rho GTPase activating protein 26. (814 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1546 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
ARHGEF28ARHGEF28 isoform 4. (1731 aa)
DEPDC1BDEP domain containing 1B. (529 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3096 aa)
FHDC1FHDC1 isoform 1. (1143 aa)
ARHGAP10Rho GTPase activating protein 10. (786 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
FAM13AFamily with sequence similarity 13, member A. (1023 aa)
ARHGAP24Rho GTPase activating protein 24. (748 aa)
STBD1Starch-binding domain-containing protein 1. (358 aa)
ARAP2ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2. (1704 aa)
ARHGAP31Rho GTPase activating protein 31. (1444 aa)
RHOARas homolog family member A. (193 aa)
EMC3ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
BHLHE23Basic helix-loop-helix family member e23. (241 aa)
ARHGAP40Rho GTPase activating protein 40. (622 aa)
TGM3Transglutaminase 3. (693 aa)
NGEFNeuronal guanine nucleotide exchange factor. (710 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (1876 aa)
TMEM87BTransmembrane protein 87B. (555 aa)
RTKNRTKN isoform 2. (563 aa)
BCAMBasal cell adhesion molecule (Lutheran blood group). (643 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
ARHGAP30ARHGAP30 isoform 3. (1101 aa)
RHPN2RHPN2 isoform 2. (686 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
LMAN1Lectin, mannose-binding, 1. (510 aa)
TEX2Testis expressed 2. (1134 aa)
RNFT1Ring finger protein, transmembrane 1. (435 aa)
JUPJunction plakoglobin. (745 aa)
C1QBPComplement component 1, q subcomponent binding protein. (282 aa)
ABRActive BCR-related protein. (840 aa)
HMOX2Heme oxygenase 2. (370 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
MYO9AMYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2547 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
ARHGAP11AARHGAP11B isoform 3. (1023 aa)
AAASAchalasia, adrenocortical insufficiency, alacrimia. (546 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
ARHGDIBRho GDP dissociation inhibitor (GDI) beta. (201 aa)
PLEKHG6Pleckstrin homology and RhoGEF domain containing G6. (790 aa)
ARHGAP32ARHGAP32 isoform 2. (2095 aa)
MCAMMelanoma cell adhesion molecule. (646 aa)
ARHGAP42Rho GTPase activating protein 42. (874 aa)
ARHGAP1Rho GTPase activating protein 1. (439 aa)
SLKSTE20 like kinase. (1236 aa)
ARHGAP19Rho GTPase activating protein 19. (499 aa)
ARHGAP22Beta 1,3-galactosyltransferase-like. (715 aa)
ACBD5Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters. (534 aa)
LBRLamin B receptor. (615 aa)
VANGL1Vang-like protein. (524 aa)
PKN2Protein kinase N2. (984 aa)
ARHGEF19Rho guanine nucleotide exchange factor (GEF) 19. (804 aa)
VAMP3Vesicle-associated membrane protein 3 (Cellubrevin). (100 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1078 aa)
ARHGAP44Rho GTPase activating protein 44. (818 aa)
PKN1PKN1 isoform 2. (948 aa)
MAPK1IP1LMitogen-activated protein kinase 1-interacting protein 1-like. (245 aa)
ENSPTRP00000079007annotation not available (323 aa)
PLEKHG4Pleckstrin homology domain containing, family G (With RhoGef domain) member 4. (1260 aa)
OLIG1-2OLIG1 isoform 1. (272 aa)
ENSPTRP00000080393annotation not available (729 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa)
STARD13StAR-related lipid transfer (START) domain containing 13. (1113 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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