(13 nodes) Interleukin-15 signaling network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK1	Tyrosine-protein kinase. (1154 aa)
	STAT5A	Signal transducer and activator of transcription. (783 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	IL2RB	Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
	JAK3	Tyrosine-protein kinase. (1124 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	IL2RG	IL2RG isoform 1. (369 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IL15RA	IL15RA isoform 11. (353 aa)
	STAT5B	Signal transducer and activator of transcription. (772 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IL15	ENSPTRP00000016382	ENSPTRP00000068237	Growth factor receptor-bound protein 2.	Interleukin; Belongs to the IL-15/IL-21 family.	0.554
GRB2	IL2RB	ENSPTRP00000016382	ENSPTRP00000024676	Growth factor receptor-bound protein 2.	Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).	0.504
GRB2	JAK1	ENSPTRP00000016382	ENSPTRP00000001425	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase.	0.769
GRB2	JAK3	ENSPTRP00000016382	ENSPTRP00000040293	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase.	0.661
GRB2	SHC1	ENSPTRP00000016382	ENSPTRP00000051735	Growth factor receptor-bound protein 2.	SHC (Src homology 2 domain containing) transforming protein 1.	0.999
GRB2	SOS1	ENSPTRP00000016382	ENSPTRP00000052023	Growth factor receptor-bound protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
GRB2	SOS2	ENSPTRP00000016382	ENSPTRP00000043790	Growth factor receptor-bound protein 2.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.999
GRB2	STAT3	ENSPTRP00000016382	ENSPTRP00000091410	Growth factor receptor-bound protein 2.	Signal transducer and activator of transcription.	0.658
GRB2	STAT5A	ENSPTRP00000016382	ENSPTRP00000015668	Growth factor receptor-bound protein 2.	Signal transducer and activator of transcription.	0.667
GRB2	STAT5B	ENSPTRP00000016382	ENSPTRP00000089134	Growth factor receptor-bound protein 2.	Signal transducer and activator of transcription.	0.657
IL15	GRB2	ENSPTRP00000068237	ENSPTRP00000016382	Interleukin; Belongs to the IL-15/IL-21 family.	Growth factor receptor-bound protein 2.	0.554
IL15	IL15RA	ENSPTRP00000068237	ENSPTRP00000074821	Interleukin; Belongs to the IL-15/IL-21 family.	IL15RA isoform 11.	0.999
IL15	IL2RB	ENSPTRP00000068237	ENSPTRP00000024676	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).	0.999
IL15	IL2RG	ENSPTRP00000068237	ENSPTRP00000047375	Interleukin; Belongs to the IL-15/IL-21 family.	IL2RG isoform 1.	0.999
IL15	JAK1	ENSPTRP00000068237	ENSPTRP00000001425	Interleukin; Belongs to the IL-15/IL-21 family.	Tyrosine-protein kinase.	0.808
IL15	JAK3	ENSPTRP00000068237	ENSPTRP00000040293	Interleukin; Belongs to the IL-15/IL-21 family.	Tyrosine-protein kinase.	0.906
IL15	SHC1	ENSPTRP00000068237	ENSPTRP00000051735	Interleukin; Belongs to the IL-15/IL-21 family.	SHC (Src homology 2 domain containing) transforming protein 1.	0.457
IL15	STAT3	ENSPTRP00000068237	ENSPTRP00000091410	Interleukin; Belongs to the IL-15/IL-21 family.	Signal transducer and activator of transcription.	0.673
IL15	STAT5A	ENSPTRP00000068237	ENSPTRP00000015668	Interleukin; Belongs to the IL-15/IL-21 family.	Signal transducer and activator of transcription.	0.691
IL15	STAT5B	ENSPTRP00000068237	ENSPTRP00000089134	Interleukin; Belongs to the IL-15/IL-21 family.	Signal transducer and activator of transcription.	0.683